The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions
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Title
The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions
Authors
Keywords
Human leukocyte antigen, Major histocompatibility complex, Adverse drug reactions, Antigen processing and presentation, Abacavir
Journal
IMMUNOGENETICS
Volume 69, Issue 8-9, Pages 617-630
Publisher
Springer Nature
Online
2017-07-10
DOI
10.1007/s00251-017-1007-5
References
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Note: Only part of the references are listed.- Potent NLRP3 Inflammasome Activation by the HIV Reverse Transcriptase Inhibitor Abacavir
- (2017) Atiye Toksoy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2017) Phillip Pymm et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape
- (2017) Phillip Pymm et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis
- (2017) Kanoot Jaruthamsophon et al. Scientific Reports
- No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury
- (2016) Lee Faulkner et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults
- (2016) Huldrych F. Günthard et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Impact of the HLA-B * 58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions
- (2016) Chau Yee Ng et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Real-world cost-effectiveness of pharmacogenetic screening for epilepsy treatment
- (2016) Zhibin Chen et al. NEUROLOGY
- Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians
- (2016) Chun-Bing Chen et al. NEUROLOGY
- Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population
- (2016) Wichittra Tassaneeyakul et al. Pharmacogenetics and Genomics
- Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population
- (2016) C-C Chang et al. PHARMACOGENOMICS JOURNAL
- Towards depersonalized abacavir therapy
- (2015) Dean J. Naisbitt et al. AIDS
- HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer
- (2015) C.-F. Xu et al. CLINICAL CANCER RESEARCH
- Cost-effectiveness of screening forHLA-A*31:01prior to initiation of carbamazepine in epilepsy
- (2015) Catrin O. Plumpton et al. EPILEPSIA
- Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury
- (2015) Seung-Hyun Kim et al. HEPATOLOGY
- Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians
- (2015) E Bridie Clemens et al. IMMUNOLOGY AND CELL BIOLOGY
- Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction
- (2015) Chia-Hsien Lin et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Promiscuous T-cell responses to drugs and drug-haptens
- (2015) Fiazia S. Yaseen et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Structural modeling of HLA-B*1502/peptide/carbamazepine/T-cell receptor complex architecture: implication for the molecular mechanism of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
- (2015) Peng Zhou et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions
- (2015) Wen-Hung Chung et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice
- (2015) M T Falta et al. Mucosal Immunology
- Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
- (2015) Rik Schrijvers et al. Clinical and Translational Allergy
- T Cells Infiltrate the Liver and Kill Hepatocytes in HLA-B ∗ 57:01-Associated Floxacillin-Induced Liver Injury
- (2014) Natascha Wuillemin et al. AMERICAN JOURNAL OF PATHOLOGY
- Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin
- (2014) Wen-Hung Chung et al. ANNALS OF THE RHEUMATIC DISEASES
- Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity
- (2014) Gina M. Clayton et al. CELL
- HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient
- (2014) Maike Lichtenfels et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Prospective Validation ofHLA-DRB1*07:01Allele Carriage As a Predictive Risk Factor for Lapatinib-Induced Liver Injury
- (2014) Daniel J. Schaid et al. JOURNAL OF CLINICAL ONCOLOGY
- Oxypurinol Directly and Immediately Activates the Drug-Specific T Cells via the Preferential Use of HLA-B*58:01
- (2014) J. Yun et al. JOURNAL OF IMMUNOLOGY
- Effects of a HLA-B*15:02 screening policy on antiepileptic drug use and severe skin reactions
- (2014) Z. Chen et al. NEUROLOGY
- The IPD and IMGT/HLA database: allele variant databases
- (2014) James Robinson et al. NUCLEIC ACIDS RESEARCH
- Abacavir Induced T Cell Reactivity from Drug Naïve Individuals Shares Features of Allo-Immune Responses
- (2014) Jacqueline Adam et al. PLoS One
- Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response
- (2013) J. Yun et al. CLINICAL AND EXPERIMENTAL ALLERGY
- HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin
- (2013) N. Wuillemin et al. JOURNAL OF IMMUNOLOGY
- HLA-B*13:01 and the Dapsone Hypersensitivity Syndrome
- (2013) F.-R. Zhang et al. NEW ENGLAND JOURNAL OF MEDICINE
- HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis
- (2013) E Genin et al. PHARMACOGENOMICS JOURNAL
- HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity
- (2013) Camilla Stephens et al. PLoS One
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- (2013) Stephan Watkins et al. PLoS One
- Relationship Between theHLA-B*1502Allele and Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
- (2013) Wimonchat Tangamornsuksan et al. JAMA Dermatology
- Abacavir induces loading of novel self-peptides into HLA-B*57
- (2012) Michael A. Norcross et al. AIDS
- Association between HLA and Stevens-Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502?
- (2012) Yi-Wu Shi et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong
- (2012) M.L.S. Chiu et al. BRITISH JOURNAL OF DERMATOLOGY
- Avidity determines T-cell reactivity in abacavir hypersensitivity
- (2012) Jacqueline Adam et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury
- (2012) Manal M. Monshi et al. HEPATOLOGY
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- Severe drug-induced hypersensitivity syndrome with a shared HLA-B allele
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- (2012) Patricia T. Illing et al. NATURE
- Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions
- (2012) Mark McCormack et al. PHARMACOGENOMICS
- HLA-B*58:01allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese
- (2012) Zhi-hao Cao et al. PHARMACOGENOMICS
- Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
- (2012) D. A. Ostrov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex
- (2011) Mandvi Bharadwaj et al. Annual Review of Pharmacology and Toxicology
- Association of HLA-B*5801 allele and allopurinol-induced stevens johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis
- (2011) Ratchadaporn Somkrua et al. BMC Medical Genetics
- Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
- (2011) Sae-Hoon Kim et al. EPILEPSY RESEARCH
- Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients
- (2011) Yan Zhang et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles
- (2011) M. Isabel Lucena et al. GASTROENTEROLOGY
- Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population
- (2011) Choong-Chor Chang et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome
- (2011) Tai-Ming Ko et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer
- (2011) Colin F. Spraggs et al. JOURNAL OF CLINICAL ONCOLOGY
- Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis
- (2011) P. Whitaker et al. JOURNAL OF IMMUNOLOGY
- Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
- (2011) X. Meng et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans
- (2011) Mark McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
- (2011) Emmanuelle Génin et al. Orphanet Journal of Rare Diseases
- Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
- (2011) Hye-Ryun Kang et al. Pharmacogenetics and Genomics
- A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients
- (2011) M Tohkin et al. PHARMACOGENOMICS JOURNAL
- Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland
- (2011) Qian Wang et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- HLA-B*1502 Strongly Predicts Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thai Patients with Neuropathic Pain
- (2011) Kongkiat Kulkantrakorn et al. Pain Practice
- HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
- (2010) Nahoko Kaniwa et al. EPILEPSIA
- Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population
- (2010) Wichittra Tassaneeyakul et al. EPILEPSIA
- Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China
- (2010) X.T. Wu et al. EPILEPSY & BEHAVIOR
- Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
- (2010) Takeshi Ozeki et al. HUMAN MOLECULAR GENETICS
- How nickel turns on innate immune cells
- (2010) Ben Roediger et al. IMMUNOLOGY AND CELL BIOLOGY
- Common risk allele in aromatic antiepileptic-drug induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese
- (2010) Shuen-Iu Hung et al. PHARMACOGENOMICS
- T Cell Allorecognition via Molecular Mimicry
- (2009) Whitney A. Macdonald et al. IMMUNITY
- Association of HLA-BFNx011502 allele and carbamazepine-inducedStevens-Johnson syndromeamong Indians
- (2009) TimirY Mehta et al. Indian Journal of Dermatology Venereology & Leprology
- HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
- (2009) Ann K Daly et al. NATURE GENETICS
- Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population
- (2009) Wichittra Tassaneeyakul et al. Pharmacogenetics and Genomics
- Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSAin vitroandin vivo
- (2009) Rosalind E. Jenkins et al. Proteomics Clinical Applications
- High Sensitivity of Human Leukocyte Antigen–B*5701 as a Marker for Immunologically Confirmed Abacavir Hypersensitivity in White and Black Patients
- (2008) Michael Saag et al. CLINICAL INFECTIOUS DISEASES
- Cost evaluation of adverse drug reactions in hospitalized patients in Taiwan: A prospective, descriptive, observational study
- (2008) Agnes L.F. Chan et al. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
- Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population
- (2008) Chaichon Locharernkul et al. EPILEPSIA
- Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity
- (2008) Diana Chessman et al. IMMUNITY
- Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
- (2008) Wen-Hung Chung et al. NATURE MEDICINE
- HLA-B*5701 Screening for Hypersensitivity to Abacavir
- (2008) Simon Mallal et al. NEW ENGLAND JOURNAL OF MEDICINE
- A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
- (2008) Christine Lonjou et al. Pharmacogenetics and Genomics
- HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis
- (2008) Nahoko Kaniwa et al. PHARMACOGENOMICS
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