The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis

ICTV Virus Taxonomy Profile: Flaviviridae

(2017) Peter Simmonds et al.   JOURNAL OF GENERAL VIROLOGY

Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

(2016) Donald B. Smith et al.   JOURNAL OF GENERAL VIROLOGY

The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

(2016) Jens Bukh   JOURNAL OF HEPATOLOGY

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

(2016) Matthias Götte et al.   Nature Reviews Gastroenterology & Hepatology

MAVS-dependent host species range and pathogenicity of human hepatitis A virus

(2016) A. Hirai-Yuki et al.   SCIENCE

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus

(2016) Asuka Hirai-Yuki et al.   mBio

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

(2015) Takahiro Masaki et al.   Cell Host & Microbe

Host–virus interactions in hepatitis B virus infection

(2015) Luca G Guidotti et al.   CURRENT OPINION IN IMMUNOLOGY

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

(2015) Jannick Prentoe et al.   GUT

Immunoglobulin with High-TiterIn VitroCross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

(2015) Jens Bukh et al.   JOURNAL OF VIROLOGY

Evolutionary origins of hepatitis A virus in small mammals

(2015) Jan Felix Drexler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Chimpanzee Model for Hepatitis B Virus Infection

(2015) S. F. Wieland   Cold Spring Harbor Perspectives in Medicine

Reassessing immune control of hepatitis A virus

(2015) Christopher M Walker et al.   Current Opinion in Virology

T-cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon-free antiviral regimen in a chimpanzee

(2014) Benoit Callendret et al.   HEPATOLOGY

Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

(2014) William O. Osburn et al.   HEPATOLOGY

Human pDCs preferentially sense enveloped hepatitis A virions

(2014) Zongdi Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

(2014) D. Ross-Thriepland et al.   JOURNAL OF GENERAL VIROLOGY

Evolution of a Cell Culture-Derived Genotype 1a Hepatitis C Virus (H77S.2) during Persistent Infection with Chronic Hepatitis in a Chimpanzee

(2014) M. Yi et al.   JOURNAL OF VIROLOGY

Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon

(2014) D. Wang et al.   JOURNAL OF VIROLOGY

Hepatitis A virus and the origins of picornaviruses

(2014) Xiangxi Wang et al.   NATURE

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

(2014) L. Swadling et al.   Science Translational Medicine

Hepatitis C virus NS5A inhibitors and drug resistance mutations

(2014) Shingo Nakamoto   WORLD JOURNAL OF GASTROENTEROLOGY

Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis

(2014) Zongdi Feng et al.   Annual Review of Virology

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

(2013) Robert E. Lanford et al.   GASTROENTEROLOGY

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

(2013) Stefan Wieland et al.   HEPATOLOGY

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Current progress in development of hepatitis C virus vaccines

(2013) T Jake Liang   NATURE MEDICINE

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

(2013) Ralf Bartenschlager et al.   NATURE REVIEWS MICROBIOLOGY

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

(2013) John Lok Man Law et al.   PLoS One

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Dominance of the CD4+T helper cell response during acute resolving hepatitis A virus infection

(2012) Yan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

(2012) Trevor J. Morin et al.   PLoS Pathogens

T cell responses in hepatitis C: the good, the bad and the unconventional

(2011) Paul Klenerman et al.   GUT

Vaccine-Induced Cross-Genotype Reactive Neutralizing Antibodies Against Hepatitis C Virus

(2011) Jean-Christophe Meunier et al.   JOURNAL OF INFECTIOUS DISEASES

Complete coding sequence and molecular analysis of hepatitis A virus from a chimpanzee with fulminant hepatitis

(2011) Apiradee Theamboonlers et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA

(2011) R. E. Lanford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

(2011) Lin Qu et al.   PLoS Pathogens

Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents

(2010) David B. Olsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Meta-Analysis of Hepatitis C Virus Vaccine Efficacy in Chimpanzees Indicates an Importance for Structural Proteins

(2010) Harel Dahari et al.   GASTROENTEROLOGY

Hepatitis B: The virus and disease

(2010) T. Jake Liang   HEPATOLOGY

Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses

(2010) Michael Houghton   IMMUNOLOGICAL REVIEWS

Challenge Pools of Hepatitis C Virus Genotypes 1–6 Prototype Strains: Replication Fitness and Pathogenicity in Chimpanzees and Human Liver–Chimeric Mouse Models

(2010) Jens Bukh et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122

(2010) R. K. Jangra et al.   JOURNAL OF VIROLOGY

Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies

(2010) J. M. Gottwein et al.   JOURNAL OF VIROLOGY

Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization

(2010) J. Prentoe et al.   JOURNAL OF VIROLOGY

Pathogenesis of hepatitis B virus infection

(2010) F.V. Chisari et al.   PATHOLOGIE BIOLOGIE

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults

(2010) Sharon E. Frey et al.   VACCINE

Hepatitis C Virus Blocks Interferon Effector Function by Inducing Protein Kinase R Phosphorylation

(2009) Urtzi Garaigorta et al.   Cell Host & Microbe

Visualizing Hepatitis C Virus Infections in Human Liver by Two-Photon Microscopy

(2009) Yuqiong Liang et al.   GASTROENTEROLOGY

Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus

(2009) Kimberly A. Dowd et al.   GASTROENTEROLOGY

Experimental hepatitis A virus (HAV) infection in cynomolgus monkeys (Macaca fascicularis): evidence of active extrahepatic site of HAV replication

(2009) Luciane A. Amado et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The long and winding road leading to the identification of the hepatitis C virus

(2009) Michael Houghton   JOURNAL OF HEPATOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Hepatitis C-associated hepatocellular carcinomas in non-cirrhotic livers

(2009) Matthew M Yeh et al.   MODERN PATHOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

(2008) S. S. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients

(2008) Daryl T.-Y. Lau et al.   HEPATOLOGY

Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation

(2008) Takanobu Kato et al.   HEPATOLOGY

Simian hepatitis A virus derived from a captive rhesus monkey in India is similar to the strain isolated from wild African green monkeys in Kenya

(2008) V. A. Arankalle et al.   JOURNAL OF VIRAL HEPATITIS

Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain

(2008) J. Bukh et al.   JOURNAL OF VIROLOGY

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA