The Complex Type 2 Endotype in Allergy and Asthma: From Laboratory to Bedside

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459

(2014) R. Pettipher et al.   ALLERGY

Differences in Initial Immunoprofiles between Recurrent and Nonrecurrent Chronic Rhinosinusitis with Nasal Polyps

(2014) Thibaut Van Zele et al.   American Journal of Rhinology & Allergy

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

(2014) Trung N. Tran et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Comparative Analysis of Human Epidermal and Peripheral Blood γδ T Cell Cytokine Profiles

(2014) Kwangmi Kim et al.   Annals of Dermatology

Immunological and molecular targets of atopic dermatitis treatment

(2014) A. Wollenberg et al.   BRITISH JOURNAL OF DERMATOLOGY

Re-defining the unique roles for eosinophils in allergic respiratory inflammation

(2014) E. A. Jacobsen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Molecular Biology of Atopic Dermatitis

(2014) Zhanglei Mu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Interleukin-17 cytokine signalling in patients with asthma

(2014) A. Linden et al.   EUROPEAN RESPIRATORY JOURNAL

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

Innate immunity in the lung regulates the development of asthma

(2014) Rosemarie H. DeKruyff et al.   IMMUNOLOGICAL REVIEWS

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma

(2014) Christopher Newby et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

(2014) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84

(2014) Taylor A. Doherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

(2014) Matthew J. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A thymic stromal lymphopoietin–responsive dendritic cell subset mediates allergic responses in the upper airway mucosa

(2014) Guro R. Melum et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

(2014) Alex Poole et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR + ILC3 in Lesional Skin and Blood of Psoriasis Patients

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TSLP Induces Mast Cell Development and Aggravates Allergic Reactions through the Activation of MDM2 and STAT6

(2014) Na-Ra Han et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Salivary Inflammatory Mediator Profiling and Correlation to Clinical Disease Markers in Asthma

(2014) Frédéric F. Little et al.   PLoS One

Factors Contributing to an Accelerated Decline in Pulmonary Function in Asthma

(2014) Yoshihiro Kanemitsu et al.   ALLERGOLOGY INTERNATIONAL

Myeloid dendritic cells type 2 in allergic asthma

(2013) B. Dua et al.   ALLERGY

Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

(2013) Dhananjay Desai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

(2013) Joanne L. Shaw et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Predicting steroid responsiveness in patients with asthma using exhaled breath profiling

(2013) M. P. van der Schee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

From phenotypes to endotypes to asthma treatment

(2013) Ioana O. Agache   Current Opinion in Allergy and Clinical Immunology

Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease

(2013) John W. Steinke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation

(2013) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

(2013) Andrei Malinovschi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis

(2013) Deepti R. Nagarkar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

(2013) Cezmi A. Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma

(2013) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

(2013) Hiroki Kabata et al.   Nature Communications

Untangling asthma phenotypes and endotypes

(2012) I. Agache et al.   ALLERGY

Asthmatic Granulomatosis

(2012) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Association betweenl-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

(2012) Fernando Holguin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Type 2 innate lymphoid cells: new players in asthma and allergy

(2012) Seth T Scanlon et al.   CURRENT OPINION IN IMMUNOLOGY

Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

(2012) Michael B. Soyka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

(2012) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Therapies for allergic inflammation: refining strategies to induce tolerance

(2012) Cezmi A Akdis   NATURE MEDICINE

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis

(2011) R. Kamekura et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

(2011) N. Barnes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Persistent High FeNO Phenotype in Asthma

(2011) I.O. Agache et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children

(2011) Georgette Stern et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

(2011) Aarti Shikotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity

(2011) Hye Young Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma

(2010) Ryan H. Dougherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased serum IL-17 is an independent risk factor for severe asthma

(2010) Ioana Agache et al.   RESPIRATORY MEDICINE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation

(2008) Zoulfia Allakhverdi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY