Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology

TACTIC: a multicentre, open-label, single-arm phase II trial of panitumumab, cisplatin, and gemcitabine in biliary tract cancer

(2016) D. Ferraro et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

(2016) Jasmin Svinka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

(2016) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma

(2016) Giuliana Cavalloni et al.   Oncotarget

Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the “Reactive” Biliary Epithelial Phenotype

(2016) Luca Fabris et al.   Stem Cells International

Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice

(2015) Lawrence A. Scheving et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells

(2015) Thanh Huong Nguyen Ho-Bouldoires et al.   FREE RADICAL BIOLOGY AND MEDICINE

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Cyclooxygenase-2-derived prostaglandin E2promotes human cholangiocarcinoma cell growth and invasion through EP1receptor-mediated activation of the epidermal growth factor receptor and Akt.

(2015) Chang Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line

(2015) Runping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P0272 : Long-term inhibition of EGFR in human cholangiocarcinoma cells leads to the induction of an epithelial to mesenchymal transition program and activation of insulin/insulin growth factor 1 receptors

(2015) J. Vaquero et al.   JOURNAL OF HEPATOLOGY

The Cholangiopathies

(2015) Konstantinos N. Lazaridis et al.   MAYO CLINIC PROCEEDINGS

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR)

(2015) Christy E. Trussoni et al.   PLoS One

Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury

(2015) Ya-Hui Chen et al.   PLoS One

Molecular Subgroup Analysis of Clinical Outcomes in a Phase 3 Study of Gemcitabine and Oxaliplatin with or without Erlotinib in Advanced Biliary Tract Cancer

(2015) Seung Tae Kim et al.   Translational Oncology

Role of ErbB Receptors in Cancer Cell Migration and Invasion

(2015) Aline Appert-Collin et al.   Frontiers in Pharmacology

The Role of ARF6 in Biliary Atresia

(2015) Mylarappa Ningappa et al.   PLoS One

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

(2014) Noushin Dianat et al.   HEPATOLOGY

Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab

(2014) Toru Kawamoto et al.   JOURNAL OF GASTROENTEROLOGY

EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition

(2014) Audrey Clapéron et al.   JOURNAL OF HEPATOLOGY

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

Expression Levels and Significance of Nuclear Factor-κB and Epidermal Growth Factor Receptor in Hepatolithiasis Associated with Intrahepatic Cholangiocarcinoma

(2013) Quanbo Zhou et al.   DIGESTIVE SURGERY

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish

(2013) Jianbo He et al.   GASTROENTEROLOGY

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

(2013) M. Kitade et al.   GENES & DEVELOPMENT

Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice

(2013) Delphine Firrincieli et al.   HEPATOLOGY

Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor

(2013) Audrey Clapéron et al.   HEPATOLOGY

Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

(2013) Bryan C. Fuchs et al.   HEPATOLOGY

Epithelial-mesenchymal transition-related protein expression in biliary epithelial cells associated with hepatolithiasis

(2013) Rohyun Sung et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair

(2013) Oihane Garcia-Irigoyen et al.   LIVER INTERNATIONAL

High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases

(2013) Sejin Jang et al.   MODERN PATHOLOGY

Bile acid accelerates erbB2-induced pro-tumorigenic activities in biliary tract cancer

(2013) Takuya Kitamura et al.   MOLECULAR CARCINOGENESIS

Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium

(2011) Srikar R Guntaka et al.   LABORATORY INVESTIGATION

Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells

(2011) A Clapéron et al.   ONCOGENE

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

(2010) Ymera Pignochino et al.   BMC CANCER

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy

(2010) Zichen Zhang et al.   HEPATOLOGY

Genetics of Biliary Tract Cancers and Emerging Targeted Therapies

(2010) Aram F. Hezel et al.   JOURNAL OF CLINICAL ONCOLOGY

Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

(2009) D Yoshikawa et al.   BRITISH JOURNAL OF CANCER

Lipopolysaccharide Initiates a Positive Feedback of Epidermal Growth Factor Receptor Signaling by Prostaglandin E2 in Human Biliary Carcinoma Cells

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Epidermal Growth Factor Receptor as a Target for Anti-Proliferative Treatment of Proliferative Cholangitis in Hepatolithiasis

(2009) Fuyu Li et al.   JOURNAL OF SURGICAL RESEARCH

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

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Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium

(2008) Pallavi B. Limaye et al.   HEPATOLOGY

Disrupted cell adhesion but not proliferation mediates cyst formation in polycystic liver disease

(2008) Esmé Waanders et al.   MODERN PATHOLOGY