Article
Multidisciplinary Sciences
Olga Zbodakova, Karel Chalupsky, Lenka Sarnova, Petr Kasparek, Marketa Jirouskova, Martin Gregor, Radislav Sedlacek
Summary: ADAM10 and ADAM17 play concurrent roles in liver regeneration and fibrosis, affecting growth receptor signaling and TNF RI release. Their pathological roles are context-dependent, with antagonistic effects observed in some models but not others.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Tomislav Kostic, Dejan Popovic, Zoran Perisic, Dragana Stanojevic, Sonja Dakic, Sandra Saric, Danijela Djordjevic Radojkovic, Svetlana Apostolovic, Nenad Bozinovic, Snezana Ciric Zdravkovic, Stefan Milutinovic, Bojan Maricic, Nikola Zivkovic, Mladjan Golubovic, Miodrag Djordjevic, Radomir Damjanovic, Abraham Bell, Boris Dindic
Summary: The study demonstrates that aminoguanidine has a significant hepatoprotective effect in acute liver damage induced by CCl4, attributed to its antioxidant effects, inhibition of pro-oxidative and pro-inflammatory mediators, and induction of damaged hepatocytes into apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Xiang Tao, Can Chen, Yingxiang Chen, Luoying Zhang, Jiong Hu, Hongjun Yu, Minglu Liang, Qin Fu, Kai Huang
Summary: This study reveals that beta(2)-adrenergic receptor (beta(2)AR) plays a critical role in liver regeneration by interacting with c-met and activating ERK signaling, leading to increased hepatocyte proliferation.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Julian Biau, Chris Nutting, Johannes A. Langendijk, Thomas Frederic-Moreau, Juliette Thariat, Lucie Piram, Romain Bellini, Nicolas Saroul, Nathalie Pham Dang, Brian O'Sullivan, Jordi Giralt, Pierre Blanchard, Jean Bourhis, Michel Lapeyre
Summary: Intensity-modulated radiotherapy is widely used for post-operative radiotherapy of salivary gland cancers. The strict definition and selection of target volumes is complex and requires extensive knowledge.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Atsushi Miura, Takashi Hosono, Taiichiro Seki
Summary: Depleting macrophages can suppress tissue remodeling and partially delay cell proliferation during regeneration after acute liver injury. Inhibiting tissue remodeling caused by depleted macrophages can delay the recovery of metabolic functions, indicating that liver injury affects liver metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Keigo Nakashima, Takeyuki Misawa, Yu Kumagai, Hiroaki Kitamura, Syuichi Fujioka, Katsuhiko Yanaga
Summary: The article presents a case of liver metastasis from submandibular gland carcinoma that was resected five years after the initial operation. It discusses liver resection as a potential treatment option for such metastasis, but highlights the need for further studies with larger patient populations to confirm its efficacy.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Medicine, Research & Experimental
Yu Sun, Hadrien Demagny, Adrien Faure, Francesca Pontanari, Antoine Jalil, Nadia Bresciani, Ece Yildiz, Melanie Korbelius, Alessia Perino, Kristina Schoonjans
Summary: The enzyme asparagine synthetase (ASNS) is responsible for the de novo synthesis of the nonessential amino acid asparagine. The expression of ASNS in pericentral hepatocytes, specialized liver cells in xenobiotic detoxification, is significantly increased in models of acute liver injury. Mice with hepatocyte-specific Asns deletion are more susceptible to pericentral liver damage, which can be reversed by intravenous administration of asparagine. The upregulation of ASNS in response to stress is mediated by the nuclear receptor, liver receptor homolog 1 (LRH-1; NR5A2) through an ATF4-independent, noncanonical pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Cheng Wang, Cheng Ma, Ke Fu, Li-Hong Gong, Ya-Fang Zhang, Hong-Lin Zhou, Yun-Xia Li
Summary: The study demonstrated that PHI can protect the intestinal epithelial barrier and attenuate CCl4-induced liver fibrosis by modulating inflammation and gut microbiota. PHI showed potential as a therapeutic agent for liver fibrosis by promoting the expression of intestinal barrier markers and enriching the abundance of beneficial bacteria such as Lactobacillus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hyun Ho Yun, Sunyoung Park, Myung-Jin Chung, Ji-Yoon Son, Jae-Min Park, Seung-Jun Jung, Jae-Hyuk Yim, Kyung-Ku Kang, Seongrim Byeon, Su-Min Baek, Seoung-Woo Lee, A-Rang Lee, Tae-Hwan Kim, Jin-Kyu Park, Kyu-Shik Jeong
Summary: The study demonstrates that L-serine can reduce the extent of hepatic fibrosis and holds potential for clinical applications.
Article
Biochemistry & Molecular Biology
Joshua Hefler, Sanaz Hatami, Aducio Thiesen, Carly Olafson, Kiarra Durand, Jason Acker, Constantine J. Karvellas, David L. Bigam, Darren H. Freed, Andrew Mark James Shapiro
Summary: This study established a model of acute liver failure (ALF) by perfusing isolated pig livers on a normothermic machine perfusion device. However, the development of toxic methemoglobinemia confounded the model, suggesting the need for alternative agents or dosing strategies in future studies.
Article
Gastroenterology & Hepatology
Guoqiang Li, Lijun Zhu, Mingwei Guo, Dongmei Wang, Meiyao Meng, Yinzhao Zhong, Zhijian Zhang, Yi Lin, Caizhi Liu, Jiawen Wang, Yahui Zhang, Yining Gao, Yuxiang Cao, Zhirui Xia, Jin Qiu, Yu Li, Shuang Liu, Haibing Chen, Wenyue Liu, Yu Han, Minghua Zheng, Lingyan Xu, Xinran Ma
Summary: This study demonstrates that Foxa3 is an important regulator of liver regeneration, maintaining normal liver cell proliferation and repair by governing Cebpb transcription. It was found that pharmacological activation of Foxa3 can accelerate hepatocyte proliferation without interfering with the termination of liver regeneration. These findings contribute to a better understanding of the mechanism of liver regeneration and provide a potential therapeutic target for treating liver injury.
Article
Dentistry, Oral Surgery & Medicine
Konstantinos Mantsopoulos, Matti Sievert, Ann-Kristin Iro, Sarina Katrin Mueller, Michael Koch, Mirco Schapher, Abbas Agaimy, Heinrich Iro
Summary: This study revealed significant differences in histopathological characteristics between pleomorphic adenomas of the parotid and submandibular glands, with submandibular PAs being characterized by an intact capsule, infrequent pseudopodia and satellite nodules.
Article
Medicine, Research & Experimental
Jeong Hun Kim, Hyangkyu Lee, Ji Min Kim, Hyung-Sik Kim, Sung-Chan Shin, Sun-Kyung Hwang, Byung-Joo Lee, Keunyoung Kim
Summary: The study showed that oligonol has a protective effect on postmenopausal rat salivary glands by reducing fibrosis levels and increasing the expression of aquaporin 1 and glucose transporter 4. The findings suggest that oligonol may be beneficial in preventing submandibular gland dysfunction in postmenopausal individuals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelinska, Joanna Kasprzyk-Pochopien, Joanna Nawrot, Agnieszka Sobczak, Malgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak
Summary: The extract from the leaves of Cynara scolymus L. has been found to have a high antioxidative potential and exhibits protective and regenerative effects on the liver, making it beneficial for reducing hepatocellular damage caused by xenobiotics.
Article
Pharmacology & Pharmacy
Hui Yong, Shulin Shan, Shuai Wang, Zhidan Liu, Zhaoxiong Liu, Cuiqin Zhang, Yiyu Yang, Zhengcheng Huang, Fuyong Song
Summary: The study reveals that abnormal accumulation of TDP-43 on mitochondria may be involved in the progression of liver fibrosis. Enhancing mitophagy to eliminate mitochondrial TDP-43 aggregation can improve mitochondrial function and promote regression of liver fibrosis.
Article
Chemistry, Medicinal
Lauren Lewis, Barbara Borowa-Mazgaj, Aline de Conti, Grace A. Chappell, Yu-Syuan Luo, Wanda Bodnar, Kranti Konganti, Fred A. Wright, David W. Threadgill, Weihsueh A. Chiu, Igor P. Pogribny, Ivan Rusyn
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Immunology
Maliha Batool, Andrew E. Hillhouse, Yurij Ionov, Kelli J. Kochan, Fatemeh Mohebbi, George Stoica, David W. Threadgill, Alex Zelikovsky, Suryakant D. Waghela, Dominique J. Wiener, Artem S. Rogovskyy
INFECTION AND IMMUNITY
(2019)
Article
Multidisciplinary Sciences
Jaye Sudweeks, Brandon Hollingsworth, Dimitri Blondel, Karl J. Campbell, Sumit Dhole, John D. Eisemann, Owain Edwards, John Godwin, Gregg R. Howald, Kevin P. Oh, Antoinette J. Piaggio, Thomas A. A. Prowse, Joshua Ross, J. Royden Saah, Aaron B. Shiels, Paul Q. Thomas, David W. Threadgill, Michael R. Vella, Fred Gould, Alun L. Lloyd
SCIENTIFIC REPORTS
(2019)
Article
Genetics & Heredity
Anika C. Bissahoyo, Yuying Xie, Lynda Yang, R. Scott Pearsall, Daekee Lee, Rosemary W. Elliott, Peter Demant, Leonard McMillan, Fernando Pardo-Manuel de Villena, Joe M. Angel, David W. Threadgill
Article
Cell Biology
Adam Price, Atsushi Okumura, Elaine Haddock, Friederike Feldmann, Kimberly Meade-White, Pryanka Sharma, Methinee Artami, W. Ian Lipkin, David W. Threadgill, Heinz Feldmann, Angela L. Rasmussen
Article
Multidisciplinary Sciences
Raena Eldridge, Daniel Osorio, Katia Amstalden, Caitlin Edwards, Colin R. Young, James J. Cai, Kranti Konganti, Andrew Hillhouse, David W. Threadgill, C. Jane Welsh, Candice Brinkmeyer-Langford
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Tiffany A. Garbutt, Kranti Konganti, Thomas Konneker, Andrew Hillhouse, Drake Phelps, Alexis Jones, David Aylor, David W. Threadgill
Article
Endocrinology & Metabolism
Anna C. Salvador, Danny Arends, William T. Barrington, Ahmed M. Elsaadi, Gudrun A. Brockmann, David W. Threadgill
Summary: Genetic mapping revealed QTLs on Chromosome 1, 5, and 7 associated with fat and lean mass gain, as well as a significant QTL on Chromosome 1 linked to serum HDL cholesterol concentration. Causal network analysis showed a connection between HDL cholesterol and fat mass gain with Fmgq1, while strong sex effects were identified at Fmgq2 and Lmgq1, influenced by diet.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Infectious Diseases
Leta Elias, John C. Blazier, Yuliya Rogovska, Kranti Konganti, Jiangli Wang, Shuling Liu, Kelley M. Thieman Mankin, Igor Nebogatkin, David W. Threadgill, Artem S. Rogovskyy
Summary: Recent studies have shown significant differences in the microbiome of Dermacentor reticulatus ticks between different geographical regions and sexes.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Genetics & Heredity
Carolina Mantilla Rojas, Michael P. McGill, Anna C. Salvador, David Bautz, David W. Threadgill
Summary: This study highlights the discrepancy between pre-clinical efficacy and clinical translation of targeted cancer therapies and the significant impact of genetic background on the response in mouse colorectal cancer models. The genetic background dependency of ERBB3 has implications for polyp growth in the intestines, with implications for the use of ERBB3 inhibitors in colorectal cancer treatment.
Review
Environmental Sciences
Danila Cuomo, Margaret J. Foster, David Threadgill
Summary: Lead poisoning is a significant public health concern in environmental justice communities and developing countries. Individual susceptibility to lead exposure varies due to genetic and epigenetic factors. Current studies have provided inconsistent evidence on the identification of susceptibility genes or early exposure biomarkers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Hui Yan, Wanbao Yang, Fenghua Zhou, Quan Pan, Kimberly Allred, Clinton Allred, Yuxiang Sun, David Threadgill, David Dostal, Carl Tong, Shaodong Guo
Summary: This study investigates the role of ovaries and ovarian hormone estrogen in cardiac function and energy metabolism. The results show that estrogen can prevent dilated cardiomyopathy, improve cardiac function and energy metabolism, and enhance lifespan. This provides a mechanistic explanation for the gender difference in the incidence of T2D and cardiovascular diseases.
CIRCULATION-HEART FAILURE
(2022)
Article
Microbiology
Kristin Scoggin, Jyotsana Gupta, Rachel Lynch, Aravindh Nagarajan, Manuchehr Aminian, Amy Peterson, L. Garry Adams, Michael Kirby, David W. Threadgill, Helene L. Andrews-Polymenis
Summary: Understanding the molecular mechanisms of resistance and tolerance to pathogen infection can help in developing novel interventions. A study on mice infected with Salmonella Typhimurium found distinct phenotypes of delayed susceptible, tolerant, and resistant strains. Tolerant strains showed lower preinfection core body temperatures, rapid disruption of body temperature postinfection, higher neutrophil levels, and more severe tissue damage compared to resistant strains. Gene analysis identified specific genes associated with tolerance and resistance, particularly fibrinogen genes.
Article
Multidisciplinary Sciences
Luke Gierus, Aysegul Birand, Mark D. Bunting, Gelshan I. Godahewa, Sandra G. Piltz, Kevin P. Oh, Antoinette J. Piaggio, David W. Threadgill, John Godwin, Owain Edwards, Phillip Cassey, Joshua V. Ross, Thomas A. A. Prowse, Paul Q. Thomas
Summary: This study demonstrates a novel gene drive strategy to eradicate invasive rodent populations on islands by leveraging the super-Mendelian transmission of the t haplotype. Transgenic mice were engineered to validate the effectiveness of this approach.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yeon Sun Kim, Jia Yuan, Amanda Dewar, Jean-Paul Borg, David W. Threadgill, Xiaofei Sun, Sudhansu K. Dey
Summary: HB-EGF recruits VANGL2 for tyrosine phosphorylation through binding to ERBB2 and ERBB3, thereby influencing uterine epithelial cell polarity and regulating the implantation process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)