The role of bone marrow microenvironment in platelet production and their implications for the treatment of thrombocytopenic diseases

Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis

(2016) Elaheh Khodadi et al.   ANNALS OF HEMATOLOGY

Genomic landscape of megakaryopoiesis and platelet function defects

(2016) E. Bianchi et al.   BLOOD

Linkage between the mechanisms of thrombocytopenia and thrombopoiesis

(2016) K. Eto et al.   BLOOD

Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage

(2016) C. M. Woolthuis et al.   BLOOD

Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets

(2016) X. Sim et al.   BLOOD

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

(2016) Xiaohong Ruby Xu et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis

(2016) Madhav Seshadri et al.   CURRENT OPINION IN HEMATOLOGY

Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress

(2016) Nobuhiro Morishima et al.   GENES TO CELLS

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling

(2016) Daniela Semeniak et al.   JOURNAL OF CELL SCIENCE

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

(2016) A. Antkowiak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation

(2015) S. Chen et al.   BLOOD

The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control

(2015) Alessandro Malara et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BMSCs and hematopoiesis

(2015) Andrés García-García et al.   IMMUNOLOGY LETTERS

Impairment of hematopoietic stem cell niches in patients with aplastic anemia

(2015) Liangliang Wu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The defective bone marrow-derived mesenchymal stem cells in patients with chronic immune thrombocytopenia

(2014) Donglei Zhang et al.   AUTOIMMUNITY

SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury

(2014) L. M. Niswander et al.   BLOOD

Thrombopoietin from beginning to end

(2014) Ian S. Hitchcock et al.   BRITISH JOURNAL OF HAEMATOLOGY

Instruction of hematopoietic lineage choice by cytokine signaling

(2014) Max Endele et al.   EXPERIMENTAL CELL RESEARCH

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Cross Talk with Hematopoietic Cells Regulates the Endothelial Progenitor Cell Differentiation of CD34 Positive Cells

(2014) Sang-Mo Kwon et al.   PLoS One

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

(2014) A. P. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment

(2014) Sofieke Klamer et al.   Cell Adhesion & Migration

Thrombopoietin levels in patients with disorders of platelet production: Diagnostic potential and utility in predicting response to TPO Receptor agonists

(2013) Robert S. Makar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Proplatelet generation in the mouse requires PKC -dependent RhoA inhibition

(2013) G. Gobbi et al.   BLOOD

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

(2013) I. Pleines et al.   BLOOD

Immunobiology of mesenchymal stem cells

(2013) S Ma et al.   CELL DEATH AND DIFFERENTIATION

Lineage Specification: Reading the Instructions May Help!

(2013) Gill May et al.   CURRENT BIOLOGY

ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation and maturation

(2013) S Chen et al.   Cell Death & Disease

Two anatomically distinct niches regulate stem cell activity

(2012) H. Ema et al.   BLOOD

Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia

(2012) Fan-Chen Ku et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

(2012) Alexia Eliades et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immune Thrombocytopenia: Pathophysiologic and Clinical Update

(2012) Roberto Stasi   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Blood platelet production and morphology

(2012) Alessandro Malara et al.   THROMBOSIS RESEARCH

Megakaryocytes derived from patients with the classical form of Bernard-Soulier syndrome show no ability to extend proplatelets in vitro

(2011) Alessandra Balduini et al.   PLATELETS

Hypothesis: Human Umbilical Cord Blood-derived Stromal Cells Promote Megakaryocytopoiesis Through the Influence of SDF-1 and PECAM-1

(2010) Yimei Feng et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4

(2010) Sven Golfier et al.   FASEB JOURNAL

Osteoblasts and Bone Marrow Mesenchymal Stromal Cells Control Hematopoietic Stem Cell Migration and Proliferation in 3D In Vitro Model

(2010) Ana Paula D. N. de Barros et al.   PLoS One

Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis

(2009) Isabella Pallotta et al.   PLoS One

TPO-independent megakaryocytopoiesis

(2008) Cuiling Zheng et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes

(2008) A. BALDUINI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS