ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation and maturation

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Platelet Function in Health and Disease: from Molecular Mechanisms, Redox Considerations to Novel Therapeutic Opportunities

(2012) Patrizia Ferroni et al.   ANTIOXIDANTS & REDOX SIGNALING

Platelet hyperaggregability in high-fat fed rats: A role for intraplatelet reactive-oxygen species production

(2012) Priscila F Monteiro et al.   Cardiovascular Diabetology

Hypoxia improves expansion potential of human cord blood-derived hematopoietic stem cells and marrow repopulation efficiency

(2012) Sushmita Roy et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Antiplatelet effect of phloroglucinol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production

(2012) Mei-Chi Chang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

Bone and the hematopoietic niche: a tale of two stem cells

(2011) P. Bianco   BLOOD

Regulatory effects of TLR2 on megakaryocytic cell function

(2011) L. M. Beaulieu et al.   BLOOD

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing

(2011) W. Feng et al.   BLOOD

Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy

(2011) Donald McCrann et al.   CELL CYCLE

Antithrombotic and profibrinolytic activities of phloroglucinol

(2011) Jong-Sup Bae   FOOD AND CHEMICAL TOXICOLOGY

The cross-talk between ROS and p38MAPKα in the Ex Vivo expanded human umbilical cord blood CD133+ cells

(2011) Jing Zou et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Astaxanthin: A Potential Therapeutic Agent in Cardiovascular Disease

(2011) Robert G. Fassett et al.   Marine Drugs

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells

(2011) Takashi Nagasawa et al.   TRENDS IN IMMUNOLOGY

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

(2010) M. Tesio et al.   BLOOD

p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation

(2010) J L Sardina et al.   CELL DEATH AND DIFFERENTIATION

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34+ cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium

(2010) Nikhat Firdaus A. Siddiqui et al.   CYTOTHERAPY

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

New Roles for Cyclin E in Megakaryocytic Polyploidization

(2010) Alexia Eliades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Interstitial Fluid in Bone Marrow Identified That Peroxiredoxin 2 Regulates H2O2Level of Bone Marrow during Aging

(2010) Wei Wang et al.   JOURNAL OF PROTEOME RESEARCH

Redox modulation of Ecto-NOX1 in human platelets

(2010) Isabella Savini et al.   MOLECULAR MEMBRANE BIOLOGY

The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies

(2010) Christina L. Grek et al.   PHARMACOLOGY & THERAPEUTICS

Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: Results of the Thrombotic RIsk Progression (TRIP) Study

(2010) Udaya S. Tantry et al.   PLATELETS

Platelet Formation

(2010) Jonathan N. Thon et al.   SEMINARS IN HEMATOLOGY

Chemical components and its antioxidant properties in vitro: An edible marine brown alga, Ecklonia cava

(2009) Yong Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation

(2009) H. Motohashi et al.   BLOOD

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis

(2009) A. Rizo et al.   BLOOD

Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy

(2009) D. J. McCrann et al.   BLOOD

Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation

(2009) Alexandra Mazharian et al.   EXPERIMENTAL HEMATOLOGY

Platelet receptors and signaling in the dynamics of thrombus formation

(2009) J. Rivera et al.   HAEMATOLOGICA

Regulation of megakaryocyte maturation and platelet formation

(2009) D. BLUTEAU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis

(2009) Isabella Pallotta et al.   PLoS One

In Vitro Megakaryocyte Production and Platelet Biogenesis: State of the Art

(2009) Jo-Anna Reems et al.   TRANSFUSION MEDICINE REVIEWS

15-deoxy- 12,14-PGJ2 enhances platelet production from megakaryocytes

(2008) J. J. O'Brien et al.   BLOOD

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Emerging treatments for thrombocytopenia: Increasing platelet production

(2008) Karen Peeters et al.   DRUG DISCOVERY TODAY

Endogenous peroxynitrite modulates PGHS-1–dependent thromboxane A2 formation and aggregation in human platelets

(2008) Stefan Schildknecht et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thrombopoietin (TPO) regulates HIF-1α levels through generation of mitochondrial reactive oxygen species

(2008) Kozue Yoshida et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

15-deoxy-Δ12,14prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis

(2008) J. J. O'BRIEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells

(2007) Jie Wang et al.   LEUKEMIA RESEARCH