Proplatelet generation in the mouse requires PKC -dependent RhoA inhibition

Does size matter in platelet production?

(2012) J. N. Thon et al.   BLOOD

Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes

(2012) Yuan Gao et al.   DEVELOPMENTAL CELL

Protein Kinase C ε Expression in Platelets from Patients with Acute Myocardial Infarction

(2012) Cecilia Carubbi et al.   PLoS One

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly

(2011) A. Jurak Begonja et al.   BLOOD

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation

(2011) S. Patel-Hett et al.   BLOOD

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

The substrates and binding partners of protein kinase Cε

(2010) Philip M. Newton et al.   BIOCHEMICAL JOURNAL

Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from patients with von Willebrand disease type 2B

(2010) P. Nurden et al.   BLOOD

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

(2010) M. Bender et al.   BLOOD

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

The regulation of proplatelet production

(2009) A. E. Geddis   HAEMATOLOGICA

Overexpression of the partially activated αIIbβ3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells

(2009) E. SCHAFFNER-RECKINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Phorbol ester-induced PKC  down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation

(2008) G. Gobbi et al.   BLOOD

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

(2008) S. Patel-Hett et al.   BLOOD

Protein kinase Cε: multiple roles in the function of, and signaling mediated by, the cytoskeleton

(2008) Yoshiko Akita   FEBS Journal

Protein kinase Cε: function in neurons

(2008) Yasuhito Shirai et al.   FEBS Journal

The regulated assembly of a PKCɛ complex controls the completion of cytokinesis

(2008) Adrian T. Saurin et al.   NATURE CELL BIOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY