Recent progress on fluorination in aqueous media

Multiple Approaches to the In Situ Generation of Anhydrous Tetraalkylammonium Fluoride Salts for SNAr Fluorination Reactions

(2017) Megan A. Cismesia et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Catalyzed Regioselective Fluorination of Carbonyl Directed Alkynes: Synthesis of α-Fluoroketones

(2017) Fang-Hui Li et al.   ORGANIC LETTERS

Silver-Catalyzed Anti-Markovnikov Hydroxyfluorination of Styrenes

(2017) Yan Li et al.   ACS Catalysis

Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution

(2017) He Chen et al.   Organic Chemistry Frontiers

[18F]-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Applications

(2016) David M. Perrin   ACCOUNTS OF CHEMICAL RESEARCH

The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination

(2016) Aaron C. Sather et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium(II)-Catalyzed Oxidative Difunctionalization of Alkenes: Bond Forming at a High-Valent Palladium Center

(2016) Guoyin Yin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Pentafluoroethylsilicic Acids

(2016) Nico Schwarze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

5-Fluoro derivatives of 4-epi-isofagomine as d-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease

(2016) Martin Thonhofer et al.   CARBOHYDRATE RESEARCH

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Fluorine and Gold: A Fruitful Partnership

(2016) Javier Miró et al.   CHEMICAL REVIEWS

18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

(2016) Sean Preshlock et al.   CHEMICAL REVIEWS

Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

(2016) Stefanie V. Kohlhepp et al.   CHEMICAL SOCIETY REVIEWS

Hydrogen-bond promoted nucleophilic fluorination: concept, mechanism and applications in positron emission tomography

(2016) Ji-Woong Lee et al.   CHEMICAL SOCIETY REVIEWS

6-Deoxyhexoses froml-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology

(2016) Zilei Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation

(2016) Sarah L. Clarke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalyst-free radical fluorination of sulfonyl hydrazides in water

(2016) Lin Tang et al.   GREEN CHEMISTRY

Bridging the gaps in 18F PET tracer development

(2016) Michael G. Campbell et al.   Nature Chemistry

Fluorination methods in drug discovery

(2016) Damian E. Yerien et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in radical-mediated fluorination through C–H and C–C bond cleavage

(2016) Hong Yan et al.   Science China-Chemistry

Electrophilic Halogenation–Reductive Elimination Chemistry of Organopalladium and -Platinum Complexes

(2015) Arkadi Vigalok   ACCOUNTS OF CHEMICAL RESEARCH

Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation

(2015) Xinxin Shao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Magnetic Droplet Microfluidics as a Platform for the Concentration of [18F]Fluoride and Radiosynthesis of Sulfonyl [18F]Fluoride

(2015) Somewhere A. Fiel et al.   ACS Applied Materials & Interfaces

A Practical Synthesis of α-Fluoroketones in Aqueous Media by Decarboxylative Fluorination of β-Ketoacids

(2015) Jian Li et al.   ADVANCED SYNTHESIS & CATALYSIS

From Unorthodox to Established: The Current Status of 18F-Trifluoroborate- and 18F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging

(2015) Vadim Bernard-Gauthier et al.   BIOCONJUGATE CHEMISTRY

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

(2015) Jan-Philip Meyer et al.   BIOCONJUGATE CHEMISTRY

Green approaches to late-stage fluorination: radiosyntheses of 18F-labelled radiopharmaceuticals in ethanol and water

(2015) Megan N. Stewart et al.   CHEMICAL COMMUNICATIONS

Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes

(2015) Xinxin Wu et al.   CHEMICAL COMMUNICATIONS

Monofluorination of Organic Compounds: 10 Years of Innovation

(2015) Pier Alexandre Champagne et al.   CHEMICAL REVIEWS

Fluorinated Oligomers and Polymers in Photopolymerization

(2015) Alessandra Vitale et al.   CHEMICAL REVIEWS

Ring-opening Fluorination of Cyclobutanols and Cyclopropanols Catalyzed by Silver

(2015) Naoki Ishida et al.   CHEMISTRY LETTERS

Radiofluorination of a Pre-formed Gallium(III) Aza-macrocyclic Complex: Towards Next-Generation Positron Emission Tomography (PET) Imaging Agents

(2015) Rajiv Bhalla et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Stereoselective Organic Reactions in Aqueous Media

(2015) Majid M. Heravi et al.   CURRENT ORGANIC CHEMISTRY

Recent Advances in Difluoromethylation Reaction

(2015) Yang Lu et al.   CURRENT ORGANIC CHEMISTRY

Recent progress in synthesis of fluorine containing monomers for polyimides

(2015) Alyona I. Wozniak et al.   JOURNAL OF FLUORINE CHEMISTRY

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

(2015) Keith E. Arntson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective Fluorination of Imidazo[1,2-a]pyridines with Selectfluor in Aqueous Condition

(2015) Ping Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Study of Silver-Catalyzed Decarboxylative Fluorination

(2015) Niki R. Patel et al.   JOURNAL OF ORGANIC CHEMISTRY

Boron based fluoride anion receptors: Electrochemical and sensory applications

(2015) V. Prakash Reddy et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Titania-Catalyzed Radiofluorination of Tosylated Precursors in Highly Aqueous Medium

(2015) Maxim E. Sergeev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis

(2015) Sandrine Ventre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Ring-Opening Strategy for the Synthesis of β- and γ-Fluorinated Ketones

(2015) Huijun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

(2015) Shichao Ren et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Highly Regio- and Stereoselective Synthesis of α-Fluorinated Imides via Fluorination of Chiral Enamides

(2015) Yan-Shuang Xu et al.   ORGANIC LETTERS

Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib

(2015) Shira D. Halperin et al.   ORGANIC LETTERS

Enhancements of Catalyst Distribution and Functioning Upon Utilization of Conducting Polymers as Supporting Matrices in DMFCs: A Review

(2015) Kingshuk Dutta et al.   Polymer Reviews

Electrophilic fluorination of 6-methyl- and 1,3,6-trimethyluracils in water

(2015) G. I. Borodkin et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

An overview of reductive trifluoromethylation reactions using electrophilic ‘+CF3’ reagents

(2015) Shi-Meng Wang et al.   TETRAHEDRON

The introduction of P–F bonds using aqueous fluoride ion and a water soluble carbodiimide: a convenient alternative synthesis of phosphorofluoridates and phosphonofluoridates

(2015) Michael F. Aldersley et al.   TETRAHEDRON LETTERS

2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography

(2015) Torsten Kniess et al.   MedChemComm

Asymmetric Fluorocyclizations of Alkenes

(2014) Jamie R. Wolstenhulme et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

(2014) Jiajia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables “Last-Step”18F Fluorination of a RGD Peptide under Ambient Aqueous Conditions

(2014) Stephen Thompson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-Catalyzed Oxidative Activation of Benzylic CH Bonds for the Synthesis of Difluoromethylated Arenes

(2014) Peng Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes

(2014) Orit Jacobson et al.   BIOCONJUGATE CHEMISTRY

Silver-catalyzed decarboxylative acylfluorination of styrenes in aqueous media

(2014) Hua Wang et al.   CHEMICAL COMMUNICATIONS

Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

(2014) Michael G. Campbell et al.   CHEMICAL REVIEWS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Enzymatic Fluorination and Biotechnological Developments of the Fluorinase

(2014) David O’Hagan et al.   CHEMICAL REVIEWS

Beyond the Balz–Schiemann Reaction: The Utility of Tetrafluoroborates and Boron Trifluoride as Nucleophilic Fluoride Sources

(2014) Alexander J. Cresswell et al.   CHEMICAL REVIEWS

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

An Efficient Method for Enhancing the Reactivity and Flexibility of [18F]Fluoride Towards Nucleophilic Substitution Using Tetraethylammonium Bicarbonate

(2014) Laurent Brichard et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct C–F Bond Formation Using Photoredox Catalysis

(2014) Montserrat Rueda-Becerril et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Radical Fluorination of Alkylboronates in Aqueous Solution

(2014) Zhaodong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorinated poly(meth)acrylate: Synthesis and properties

(2014) Wenqiang Yao et al.   POLYMER

Eco-friendly fluorination of 6-methyl- and 1,3,6-trimethyluracils in water

(2014) G. I. Borodkin et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

The reaction of activated RNA species with aqueous fluoride ion: a convenient synthesis of nucleotide 5′-phosphorofluoridates and a note on the mechanism

(2014) Michael F. Aldersley et al.   TETRAHEDRON LETTERS

Late-stage [18F]fluorination: new solutions to old problems

(2014) Allen F. Brooks et al.   Chemical Science

Formal fluorine atom transfer radical addition: silver-catalyzed carbofluorination of unactivated alkenes with ketones in aqueous solution

(2014) Lin Zhu et al.   Organic Chemistry Frontiers

C sp 3F Bond Formation: A Free-Radical Approach

(2013) Mukund P. Sibi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

(2013) Manoj B. Gawande et al.   CHEMICAL SOCIETY REVIEWS

Difluoromethylation and trifluoromethylation reagents derived from tetrafluoroethane β-sultone: Synthesis, reactivity and applications

(2013) Cheng-Pan Zhang et al.   COORDINATION CHEMISTRY REVIEWS

Anion capture and sensing with cationic boranes: on the synergy of Coulombic effects and onium ion-centred Lewis acidity

(2013) Haiyan Zhao et al.   DALTON TRANSACTIONS

Mono and difluorination of centers α to sulfonates and phosphonates using AcOF

(2013) Inna Vints et al.   JOURNAL OF FLUORINE CHEMISTRY

The synthesis of α,α-difluoroacetamides via electrophilic fluorination in the mixed-solvent of water and PEG-400

(2013) Zhiguo Zhang et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis of α-fluoroketones and α-fluoroenones in aqueous media

(2013) Yan He et al.   JOURNAL OF FLUORINE CHEMISTRY

P-Spiro phosphonium salts catalyzed asymmetric fluorination of 3-substituted benzofuran-2(3H)-ones

(2013) Chuan-Le Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Polymer-immobilized fluorinase: Recyclable catalyst for fluorination reactions

(2013) Maxim E. Sergeev et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Silver-Catalyzed Radical Aminofluorination of Unactivated Alkenes in Aqueous Media

(2013) Zhaodong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Radical Phosphonofluorination of Unactivated Alkenes

(2013) Chengwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radiofluorination of diaryliodonium tosylates under aqueous–organic and cryptand-free conditions

(2013) Joong-Hyun Chun et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

One-Pot Gold-Catalyzed Aminofluorination of Unprotected 2-Alkynylanilines

(2013) Antonio Arcadi et al.   ORGANIC LETTERS

Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes

(2013) Satoshi Mizuta et al.   ORGANIC LETTERS

Evaluation of Novel Synthetic Methods for the Preparation of the Sodium Channel Inhibitor, GW273225X

(2013) Matthew D. Walker et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Facile Synthesis of 2-Fluoro-1,3-dicarbonyl Compounds with Aqueous Hydrofluoric Acid Mediated by Iodosylarenes

(2013) Tsugio Kitamura et al.   SYNTHESIS-STUTTGART

Bi-functional fluoroalkylation reagents: an introduction to halo-substituted 3-oxa-perfluoroalkanesulfonyl fluorides

(2013) Cheng-Pan Zhang et al.   TETRAHEDRON

Synthesis of β-fluoroenones and their reductive rearrangement in aqueous media

(2013) Yan He et al.   TETRAHEDRON

Catalytic fluorination of 1,3-dicarbonyl compounds using iodoarene catalysts

(2013) Tsugio Kitamura et al.   TETRAHEDRON LETTERS

Triaza-macrocyclic complexes of aluminium, gallium and indium halides: fast18F and19F incorporation via halide exchange under mild conditions in aqueous solution

(2013) Rajiv Bhalla et al.   Chemical Science

Transition-metal-free, room-temperature radical azidofluorination of unactivated alkenes in aqueous solution

(2013) Zhaodong Li et al.   Organic Chemistry Frontiers

Photo-fluorodecarboxylation of 2-Aryloxy and 2-Aryl Carboxylic Acids

(2012) Joe C. T. Leung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Lyophilized Kit for Rapid Radiofluorination of Peptides

(2012) William J. McBride et al.   BIOCONJUGATE CHEMISTRY

Sulfonyl Fluoride-Based Prosthetic Compounds as Potential18F Labelling Agents

(2012) James A. H. Inkster et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reactions of Fluorinated Organic Radicals in Aqueous Media

(2012) Sebastián Barata-Vallejo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Single-Step Radiosynthesis of “18F-Labeled Click Synthons” from Azide-Functionalized Diaryliodonium Salts

(2012) Joong-Hyun Chun et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

[18F]Fluoride labelling of macromolecules in aqueous conditions: silicon and boroaryl-based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation

(2012) Tim A. D. Smith   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Fluorine Transfer to Alkyl Radicals

(2012) Montserrat Rueda-Becerril et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F] Fluoride

(2012) Eunsung Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe(III)/NaBH4-Mediated Free Radical Hydrofluorination of Unactivated Alkenes

(2012) Timothy J. Barker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution

(2012) Feng Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harvesting 18F-fluoride ions in water via direct 18F–19F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

(2012) Zibo Li et al.   MedChemComm

Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study

(2011) Dinesh Shetty et al.   CHEMICAL COMMUNICATIONS

Transition metal catalysis and nucleophilic fluorination

(2011) Charlotte Hollingworth et al.   CHEMICAL COMMUNICATIONS

Synthesis and purification of [2-13C]-5-fluorouracil

(2011) Huzaifa S. Rangwala et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Recent Advances in the Application of SelectfluorTMF-TEDA-BF4 as a Versatile Mediator or Catalyst in Organic Synthesis

(2011) Stojan Stavber   MOLECULES

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Nucleophilic Fluorination Reactions Starting from Aqueous Fluoride Ion Solutions

(2011) Haiyan Zhao et al.   ORGANIC LETTERS

A Practical and Convenient Fluorination of 1,3-Dicarbonyl Compounds Using Aqueous HF in the Presence of Iodosylbenzene

(2011) Tsugio Kitamura et al.   ORGANIC LETTERS

Towards Greener Fluorine Organic Chemistry: Direct Electrophilic Fluorination of Carbonyl Compounds in Water and Under Solvent-Free Reaction Conditions

(2010) Gaj Stavber et al.   ADVANCED SYNTHESIS & CATALYSIS

Improved18F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex

(2010) William J. McBride et al.   BIOCONJUGATE CHEMISTRY

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

(2010) Richard N. Butler et al.   CHEMICAL REVIEWS

Elemental fluorine. Part 24.[1]: Fluorination of ethers by fluorine and Selectfluor

(2010) Richard D. Chambers et al.   JOURNAL OF FLUORINE CHEMISTRY

A Novel Facile Method of Labeling Octreotide with 18F-Fluorine

(2010) P. Laverman et al.   JOURNAL OF NUCLEAR MEDICINE

d-Glucose- and d-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-d-glucoses and -d-mannoses

(2009) Izabela Fokt et al.   CARBOHYDRATE RESEARCH

Organic Synthesis “On Water”

(2009) Arani Chanda et al.   CHEMICAL REVIEWS

A Novel Method of 18F Radiolabeling for PET

(2009) W. J. McBride et al.   JOURNAL OF NUCLEAR MEDICINE

Study on the selectivity in the electrophilic monofluorination of 2,3-allenoates with Selectfluor™: an efficient synthesis of 4-fluoro-2(5H)-furanones and 3-fluoro-4-oxo-2(E)-alkenoates

(2009) Bo Lü et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Micellar-System-Mediated Direct Fluorination of Ketones in Water

(2009) Stojan Stavber et al.   SYNLETT

Synthesis of 8-Fluorinated Erythromycin Cyclic 2′,3′-Carbamates

(2009) Audun Heggelund et al.   SYNTHETIC COMMUNICATIONS

Electrophilic fluorination: the aminopyridine dilemma

(2009) Stephen C. Fields et al.   TETRAHEDRON LETTERS

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fragmentation of Carbohydrate Anomeric Alkoxyl Radicals: New Synthesis of Chiral 1-Fluoro-1-halo-1-iodoalditols

(2008) Cosme G. Francisco et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthetic studies of 3-(3-fluorooxindol-3-yl)-l-alanine

(2008) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Towards the preparation of 2″-deoxy-2″-fluoro-adenophostin A. Study of the glycosylation reaction

(2008) David Benito et al.   TETRAHEDRON

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

An Efficient Approach for Monofluorination via Aqueous Fluorolactonization Reaction of 2,3-Allenoic Acids with Selectfluor

(2007) Chao Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY