2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography

Selective binding to monoamine oxidase A: In vitro and in vivo evaluation of 18F-labeled β-carboline derivatives

(2015) Hanno Schieferstein et al.   BIOORGANIC & MEDICINAL CHEMISTRY

18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent

(2015) Fang Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Fluorine-18 β-Fluoroethoxy Organophosphate Positron Emission Tomography Imaging Tracer Targeted to Central Nervous System Acetylcholinesterase

(2014) Shelly L. James et al.   ACS Chemical Neuroscience

Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent

(2014) Yuan-Yuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one-step synthesis of the dopamine transporter PET ligand [18F]FECNT

(2014) J. Pijarowska-Kruszyna et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and Evaluation of Three Structurally Related 18F-Labeled Orvinols of Different Intrinsic Activities: 6-O-[18F]Fluoroethyl-diprenorphine ([18F]FDPN), 6-O-[18F]Fluoroethyl-buprenorphine ([18F]FBPN), and 6-O-[18F]Fluoroethyl-phenethyl-orvinol ([18F]FPEO)

(2014) Bent W. Schoultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of [18F]-Labeled Pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine (SCH442416) Analogs for the Imaging of Cerebral Adenosine A2A Receptors with Positron Emission Tomography

(2014) Shivashankar Khanapur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

(2014) Markus Piel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of 18F-Labeled Fluoroethoxy Tryptophan Analogues as Potential PET Tumor Imaging Agents

(2014) Aristeidis Chiotellis et al.   MOLECULAR PHARMACEUTICS

PET imaging of inflammation in atherosclerosis

(2014) Jason M. Tarkin et al.   Nature Reviews Cardiology

Positron Emission Tomography (PET) in Oncology

(2014) Andrea Gallamini et al.   Cancers

HPMA-LMA Copolymer Drug Carriers in Oncology: An in Vivo PET Study to Assess the Tumor Line-Specific Polymer Uptake and Body Distribution

(2013) Mareli Allmeroth et al.   BIOMACROMOLECULES

Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors

(2013) Sven Rötering et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vivo evaluation of [18F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([18F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primates

(2013) Vattoly J. Majo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699

(2013) Fabien Caillé et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the structure–activity relationship of a novel tetracyclic class of TSPO ligands—Potential novel positron emitting tomography imaging agents

(2013) Dennis O’Shea et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Radiopharmacological Characterisation of a Fluorine-18-Labelled Azadipeptide Nitrile as a Potential PET Tracer for in vivo Imaging of Cysteine Cathepsins

(2013) Reik Löser et al.   ChemMedChem

Two-step radiosynthesis of [18F]FE-β-CIT and [18F]PR04.MZ

(2013) Patrick J. Riss et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis, Radiofluorination, and in Vivo Evaluation of Novel Fluorinated and Iodinated Radiotracers for PET Imaging and Targeted Radionuclide Therapy of Melanoma

(2013) Emilie M. F. Billaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Characterization of a Novel Series of Agonist Compounds as Potential Radiopharmaceuticals for Imaging Dopamine D2/3 Receptors in Their High-Affinity State

(2013) Jan-Peter van Wieringen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

(2013) Bent Schoultz et al.   MOLECULES

Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18

(2013) Marc Pretze et al.   MOLECULES

Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology

(2013) Patrick J. Riss et al.   MedChemComm

[18F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches

(2012) Cécile Philippe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system

(2012) Dominic Franck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro evaluation of [18F](R)-FEPAQ: A potential PET ligand for VEGFR2

(2012) Jaya Prabhakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: Potential PET imaging agents for tumor detection

(2012) Yurong Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the structure–activity relationship of the diaryl anilide class of ligands for translocator protein—potential novel positron emitting tomography imaging agents

(2012) Harry Wadsworth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The development of potential new fluorine-18 labelled radiotracers for imaging the GABAA receptor

(2012) Alexander Jackson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions

(2012) A. Afshar-Oromieh et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Optimization of labeling dipicolylamine derivative, N,N'-(5-(4-aminobutoxy)-1,3-phenylene)bis(methylene)bis(1-(pyridin-2-yl)-N-(pyridin-2-ylmethyl)methanamine), with three 18F-prosthetic groups as potential imaging agents for metastatic infectious disease

(2012) Junling Li et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

5-(2-18F-Fluoroethoxy)-L-Tryptophan as a Substrate of System L Transport for Tumor Imaging by PET

(2012) S. D. Kramer et al.   JOURNAL OF NUCLEAR MEDICINE

Radiosynthesis of [18F]FEt-Tyr-urea-Glu ([18F]FEtTUG) as a new PSMA ligand

(2012) E. Al-Momani et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)

(2012) Marc B. Skaddan et al.   NUCLEAR MEDICINE AND BIOLOGY

Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer

(2011) Ting Sun et al.   APPLIED RADIATION AND ISOTOPES

Synthesis, labelling and evaluation of hydantoin-substituted indole carboxylic acids as potential ligands for positron emission tomography imaging of the glycine binding site of the N-methyl-d-aspartate receptor

(2011) A. Bauman et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine based on a cartridge purification method

(2011) Dirk Mueller et al.   NUCLEAR MEDICINE AND BIOLOGY

Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach

(2011) Giancarlo Pascali et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis, structure determination, and (radio-)fluorination of novel functionalized phosphanes suitable for the traceless Staudinger ligation

(2011) Constantin Mamat et al.   TETRAHEDRON

Synthesis and Cardiac Imaging of 18F-Ligands Selective for β1-Adrenoreceptors

(2011) Heike S. Radeke et al.   ACS Medicinal Chemistry Letters

A Novel 18F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques

(2011) Behrooz H. Yousefi et al.   ACS Medicinal Chemistry Letters

Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists

(2010) Bidhan A. Shinkre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro evaluation of 18F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET

(2010) Edward G. Robins et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiofluorinated Pyrimidine-2,4,6-triones as Molecular Probes for Noninvasive MMP-Targeted Imaging

(2010) Hans-Jörg Breyholz et al.   ChemMedChem

Click-Chemistry Reactions in Radiopharmaceutical Chemistry: Fast & Easy Introduction of Radiolabels into Biomolecules for In Vivo Imaging

(2010) C. Wangler et al.   CURRENT MEDICINAL CHEMISTRY

Microfluidic approach for fast labeling optimization and dose-on-demand implementation

(2010) Giancarlo Pascali et al.   NUCLEAR MEDICINE AND BIOLOGY

18F-Labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging

(2010) Fabian Debus et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis and evaluation of l-5-(2-[18F]fluoroethoxy)tryptophan as a new PET tracer

(2009) Ruifen Li et al.   APPLIED RADIATION AND ISOTOPES

Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent

(2009) Tobias K. Heinrich et al.   APPLIED RADIATION AND ISOTOPES

Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [18F]FETos for In Vivo Imaging by Positron Emission Tomography

(2009) Matthias M. Herth et al.   BIOMACROMOLECULES

Structure–activity relationship of etomidate derivatives at the GABAA receptor: Comparison with binding to 11β-hydroxylase

(2009) Erika Atucha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [18F]AH1.MZ as a serotonin 5-HT1Areceptor antagonist for molecular imaging

(2009) Matthias M. Herth et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

18F- and 11C-labelling of quantum dots with n.c.a. [18F]fluoroethyltosylate and [11C]methyliodide: a feasibility study

(2009) M. Patt et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Basal opioid receptor binding is associated with differences in sensory perception in healthy human subjects: A [18F]diprenorphine PET study

(2009) Christina Mueller et al.   NEUROIMAGE

18F-Labelled metomidate analogues as adrenocortical imaging agents

(2009) Maria Erlandsson et al.   NUCLEAR MEDICINE AND BIOLOGY

Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [18F]MH.MZ

(2009) Matthias M. Herth et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Axial dispersion, holdup and slip velocity of dispersed phase in a pulsed sieve plate extraction column by radiotracer residence time distribution analysis

(2008) Ghiyas Ud Din et al.   APPLIED RADIATION AND ISOTOPES

3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: Chemical synthesis, evaluation in vitro and radiofluorination

(2008) Uta Funke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-Labeled FAUC 346 and BP 897 Derivatives as Subtype-Selective Potential PET Radioligands for the Dopamine D3 Receptor

(2008) Carsten Hocke et al.   ChemMedChem

Synthesis of [18F]fluoroacetaldehyde. Application to [18F]fluoroethylation of benzylamine under reductive alkylation conditions

(2008) C. Prenant et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

18F-Labelled vorozole analogues as PET tracer for aromatase

(2008) Maria Erlandsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis, Radiofluorination, and In Vitro Evaluation of Pyrazolo[1,5-a]pyridine-Based Dopamine D4Receptor Ligands: Discovery of an Inverse Agonist Radioligand for PET

(2008) Olaf Prante et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker

(2007) Rainer Tietze et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for β-amyloid plaques in Alzheimer's disease

(2007) Ming-Qiang Zheng et al.   JOURNAL OF FLUORINE CHEMISTRY