Article
Multidisciplinary Sciences
Murielle Murielle Beaubrun-Renard, Jacqueline Veronique-Baudin, Jonathan Macni, Stephen Ulric-Gervaise, Thierry Almont, Aude Aline-Fardin, Nathalie Grossat, Cristina Furtos, Patrick Escarmant, Vincent Vinh-Hung, Stefanos Bougas, Andre Cabie, Clarisse Joachim
Summary: This study investigated the survival and prognostic factors of women with breast cancer in Martinique, a French overseas territory, from 2008 to 2017. The findings showed overall good prognosis for breast cancer patients and identified several factors associated with increased risk of death, including metastatic disease, triple negative breast cancer, HR+/HER2- status, and age over 75.
Article
Medicine, General & Internal
Elizabeth B. Elimimian, Thomas A. Samuel, Hong Liang, Leah Elson, Nadeem Bilani, Zeina A. Nahleh
Summary: This study analyzed clinical and treatment characteristics of rare triple-negative breast cancer types, showing that medullary carcinoma and adenoid cystic carcinoma have higher 5-year survival rates compared to metaplastic carcinoma. Metaplastic carcinoma presents at older age, with lower rates of chemotherapy and radiation therapy.
Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Madoka Sakata-Matsuzawa, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Katrin Beate Ishii-Schrade, Atsushi Matsuda, Atsushi Kuno, Misato Okazaki, Katsuya Nakai, Yoshiya Horimoto, Mitsue Saito, Tatsuro Irimura
Summary: The study aimed to uncover unique glycan profiles of relapsed TNBC patients by examining lectin binding intensities. Lectin microarray analysis showed higher TJA-II, WFA, and BPL binding in relapsed TNBC cells compared to non-relapsed cells. These findings could potentially lead to the development of new prognostic and therapeutic strategies.
Article
Oncology
Carlota Pascoal, Mylene A. Carrascal, Daniela F. Barreira, Rita A. Lourenco, Pedro Granjo, Ana R. R. Grosso, Paula Borralho, Sofia Braga, Paula A. A. Videira
Summary: This study investigated the relevance of sLe(X/A) in TNBC by analyzing patient tissues, cell lines, and datasets. The results showed that sLe(X/A) is associated with lower disease-free survival in TNBC patients and negatively correlated with cytokeratins. Inhibition of sLe(X/A) increased the expression of cytokeratins and reduced proliferation and invasion capacity in vitro. This study highlights sLe(X/A) as a critical biomarker and potential therapeutic target for TNBC.
Article
Oncology
Yi Xiao, Xiaoyu Jiang, Ke Yin, Tianshu Miao, Hanlin Lu, Wenqing Wang, Lijuan Ma, Yinghui Zhao, Chunyan Liu, Yun Qiao, Pengju Zhang
Summary: The under-characterized deubiquitinase USP35 is found to be overexpressed in colorectal cancer (CRC) and promotes cell proliferation and chemotherapy resistance. The study identifies alpha-L-fucosidase 1 (FUCA1) as a direct deubiquitination target of USP35 and demonstrates its essential role in CRC cell proliferation and chemo-resistance. The USP35-FUCA1 axis may contribute to platinum resistance in CRC by up-regulating nucleotide excision repair (NER) components.
Article
Chemistry, Multidisciplinary
Xi-yu Mei, Jing-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang, Tian-yu Zhang, Li-li Ji
Summary: In this study, researchers found that Scutellarin (SC), a natural flavonoid, can reduce the metastasis of triple-negative breast cancer (TNBC) by alleviating tumor-associated vascular endothelial barrier injury. SC regulates the TNF alpha-TNFR2-ERK1/2-EZH2 signaling pathway and restores the reduced expression of junctional proteins, thereby suppressing TNBC metastasis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Francesca Ligorio, Riccardo Lobefaro, Giovanni Fuca, Leonardo Provenzano, Lucrezia Zanenga, Vincenzo Nasca, Caterina Sposetti, Giulia Salvadori, Angela Ficchi, Andrea Franza, Antonia Martinetti, Elisa Sottotetti, Barbara Formisano, Catherine Depretto, Gianfranco Scaperrotta, Antonino Belfiore, Andrea Vingiani, Cristina Ferraris, Giancarlo Pruneri, Filippo de Braud, Claudio Vernieri
Summary: Severe calorie restriction in the form of cyclic fasting or fasting-mimicking diets enhances the antitumor activity of cytotoxic chemotherapy in mouse models of triple-negative breast cancer. Clinical evidence suggests that cyclic fasting-mimicking diets may have a positive impact on the outcomes of advanced triple-negative breast cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Jose P. Leone, Noah Graham, Julieta Leone, Sara M. Tolaney, Bernardo A. Leone, Rachel A. Freedman, Michael J. Hassett, Carlos T. Vallejo, Eric P. Winer, Nancy U. Lin, Nabihah Tayob
Summary: This study developed a tool called "ESTIMATE-TN" to assess the risk of breast cancer-specific mortality (BCSM), non-BCSM, and all-cause mortality in non-metastatic triple-negative breast cancer (TNBC) patients. The tool allows input of patient and tumor characteristics and provides a nonparametric estimate of cumulative risks using Gray's subdistribution method.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Cell Biology
Diane Dayoung Park, Gege Xu, Simon S. Park, Nathan E. Haigh, Chatchai Phoomak, Sopit Wongkham, Emanual Maverakis, Carlito B. Lebrilla
Summary: Research has found that secreted proteins in cholangiocarcinoma (CCA) cells are mainly fucosylated and fucosialylated glycoforms. By analyzing the glycan and protein profiles, it was discovered that combining the genes encoding fucosyltransferases and sialyltransferases with secretory protein-coding gene expression, particularly thrombospondin-1, had favorable prognostic effects and could provide improved risk assessment and indicate stages of disease progression in CCA patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Jie Ping, Shuya Huang, Jie Wu, Pingping Bao, Timothy Su, Kai Gu, Hui Cai, Xingyi Guo, Loren Lipworth, William J. Blot, Wei Zheng, Qiuyin Cai, Xiao-Ou Shu
Summary: Long intergenic non-coding RNAs (lincRNAs) have been identified as important regulators in breast cancer, including the triple-negative subtype. Using RNA-Seq data from 200 TNBC patients, 25 lincRNAs were associated with overall survival and 61 with disease-free survival. Two specific lincRNAs, LINC01270 and LINC00449, were significantly associated with worse overall survival and DFS, and showed higher expression in tumor tissues compared to normal tissues. In vitro experiments suggested that these lincRNAs may serve as prognostic biomarkers for TNBC.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
J. Cortes, H. S. Rugo, D. W. Cescon, S-A Im, M. M. Yusof, C. Gallardo, O. Lipatov, C. H. Barrios, J. Perez-Garcia, H. Iwata, N. Masuda, M. Torregroza Otero, E. Gokmen, S. Loi, Z. Guo, X. Zhou, V Karantza, W. Pan, P. Schmid
Summary: The addition of pembrolizumab to chemotherapy significantly improves overall survival in patients with advanced triple-negative breast cancer whose tumors express PD-L1 with a CPS of 10 or more.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell Biology
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian
Summary: This study found that the expression of checkpoint suppressor 1 (CHES1) is highly associated with triple-negative breast cancer (TNBC) and plays a role in promoting the proliferation and metastasis of TNBC. Acetylation of CHES1 enhances its stability and contributes to its high abundance in TNBC. These findings highlight the significance of CHES1 acetylation in breast cancer progression.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Yu-Tien Chang, Wen-Chiuan Tsai, Wei-Zhi Lin, Chia-Chao Wu, Jyh-Cherng Yu, Vincent S. Tseng, Guo-Shiou Liao, Je-Ming Hu, Huan-Ming Hsu, Yu-Jia Chang, Meng-Chiung Lin, Chi-Ming Chu, Chien-Yi Yang
Summary: This study analyzed the function and prognostic value of immunoglobulin lambda constant 2 (IGLC2) in triple-negative breast cancer (TNBC) patients. The results showed that low expression of IGLC2 was associated with unfavorable relapse-free survival (RFS) and distant metastasis-free survival (DMFS). High expression of IGLC2 was related to a favorable prognosis and immune response in TNBC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yi-Chen Hsieh, Er-Chieh Cho, Shih-Hsin Tu, Chih-Hsiung Wu, Chin-Sheng Hung, Mao-Chih Hsieh, Chien-Tien Su, Yun-Ru Liu, Chia-Hwa Lee, Yuan-Soon Ho, Hung-Yi Chiou
ANNALS OF SURGICAL ONCOLOGY
(2017)
Review
Food Science & Technology
Shih-Hsin Tu, Li-Ching Chen, Yuan-Soon Ho
JOURNAL OF FOOD AND DRUG ANALYSIS
(2017)
Article
Oncology
Sukhontip Klahan, Henry Sung-Ching Wong, Shih-Hsin Tu, Wan-Hsuan Chou, Yan-Feng Zhang, Thien-Fiew Ho, Chih-Yi Liu, Shih-Ying Yih, Hsing Fang Lu, Sean Chun-Chang Chen, Chi-Cheng Huang, Wei-Chiao Chang
Article
Biochemistry & Molecular Biology
Shih-Hsin Tu, Yi-Shiou Chiou, Nagabhushanam Kalyanam, Chi-Tang Ho, Li-Ching Chen, Min-Hsiung Pan
Article
Oncology
Ka-Wai Tam, Chi-Tang Ho, Shih-Hsin Tu, Wen-Jui Lee, Ching-Shui Huang, Ching-Shyang Chen, Chih-Hsiung Wu, Chia-Hwa Lee, Yuan-Soon Ho
Article
Pathology
Abdul-Fattah Satah Fararjeh, Shih-Hsin Tu, Li-Ching Chen, Yun-Ru Liu, Yen-Kuang Lin, Hang-Lung Chang, Hui-Wen Chang, Chih-Hsiung Wu, Wendy W. Hwang-Verslues, Yuan-Soon Ho
Article
Oncology
Juo-Han Lin, Shih-Hsin Tu, Li-Ching Chen, Chi-Cheng Huang, Hang-Lung Chang, Tzu-Chun Cheng, Hui-Wen Chang, Chih-Hsiung Wu, Han-Chung Wu, Yuan-Soon Ho
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Environmental Sciences
Abdul-Fattah Salah Fararjeh, Shih-Hsin Tu, Li-Ching Chen, Tzu-Chun Cheng, Yun-Ru Liu, Hang-Lung Chang, Hui-Wen Chang, Chi-Cheng Huang, Hwa-Chain Robert Wang, Wendy W. Hwang-Verslues, Chih-Hsiung Wu, Yuan-Soon Ho
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Oncology
Wei-Hwa Lee, Li-Ching Chen, Chia-Jung Lee, Chi-Cheng Huang, Yuan-Soon Ho, Po-Sheng Yang, Chi-Tang Ho, Hang-Lung Chang, I-Hsuan Lin, Hui-Wen Chang, Yun-Ru Liu, Chih-Hsiung Wu, Shih-Hsin Tu
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Cell Biology
Juo-Han Lin, Wen-Jui Lee, Han-Chung Wu, Chih-Hsiung Wu, Li-Ching Chen, Chi-Cheng Huang, Hang-Lung Chang, Tzu-Chun Cheng, Hui-Wen Chang, Chi-Tang Ho, Shih-Hsin Tu, Yuan-Soon Ho
CELL ADHESION & MIGRATION
(2019)
Article
Chemistry, Physical
Chia-Hsuan Tseng, Wan-Ting Huang, Chee Ho Chew, Jun-Kai Lai, Shih-Hsin Tu, Po-Li Wei, Kang-Yun Lee, Gi-Ming Lai, Chien-Chung Chen
Article
Oncology
Chia-Hsin Wu, Hsien-Tang Yeh, Chia-Shan Hsieh, Chi-Cheng Huang, Amrita Chattopadhyay, Yuan-Chiang Chung, Shih-Hsin Tu, Yung-Hua Li, Tzu-Pin Lu, Liang-Chuan Lai, Ming-Feng Hou, King-Jen Chang, Mong-Hsun Tsai, Eric Y. Chuang
Summary: This study analyzed genomic data from 10 localized breast cancer patients with ipsilateral breast tumor relapse (IBTR), finding that homologous recombination deficiency, inactivation of the HR pathway, chromosomal instability, and somatic driver mutations were more frequently seen in IBTR compared to primary breast tumors. Three major evolution models in IBTR were identified, showing shifts in mutational signatures and expansions of subclonal diversity. Treatment regimens were suggested based on clinically relevant molecular features, such as HR deficiency or specific alterations with sensitivity to FDA-approved drugs, with a rationale provided for the development of a therapeutic management framework. This research sheds light on the complex evolution patterns in IBTR and has important implications for improving treatment decisions in the future.
Article
Biochemistry & Molecular Biology
Wen-Jui Lee, Shih-Hsin Tu, Tzu-Chun Cheng, Juo-Han Lin, Ming-Thau Sheu, Ching-Chuan Kuo, Chun A. Changou, Chih-Hsiung Wu, Hui-Wen Chang, Hang-Lung Chang, Li-Ching Chen, Yuan-Soon Ho
Summary: HAS3 and HA detected in breast tissues at high levels attenuate effects for induced breast cancer cell death, and inhibit cancer cells invasion at the initial stage. However, highly migratory cancer cells were resistant to the HA-mediated effects with unknown mechanisms.
Article
Oncology
Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Chia-Hwa Lee
Article
Oncology
Yi-Chen Hsieh, Shih-Hsin Tu, Chien-Tien Su, Er-Chieh Cho, Chih-Hsiung Wu, Mao-Chih Hsieh, Shiyng-Yu Lin, Yun-Ru Liu, Chin-Sheng Hung, Hung-Yi Chiou
BREAST CANCER RESEARCH AND TREATMENT
(2017)