Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects

ADSSL 1 mutation relevant to autosomal recessive adolescent onset distal myopathy

(2015) Hyung Jun Park et al.   ANNALS OF NEUROLOGY

Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples

(2015) Pär Jonsson et al.   Metabolomics

Familial aggregation of Parkinson's disease in the Faroe Islands

(2015) Maria Skaalum Petersen et al.   MOVEMENT DISORDERS

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

(2015) Jessica R. Gooding et al.   Cell Reports

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

(2014) Julien Averous et al.   CELLULAR SIGNALLING

Defective Autophagy in Parkinson’s Disease: Lessons from Genetics

(2014) H. Zhang et al.   MOLECULAR NEUROBIOLOGY

Untargeted 1H-NMR metabolomics in CSF: Toward a diagnostic biomarker for motor neuron disease

(2014) H. Blasco et al.   NEUROLOGY

Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease

(2014) Nicolaas I. Bohnen et al.   PARKINSONISM & RELATED DISORDERS

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics

(2014) Kay A. Lawton et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Exenatide and the treatment of patients with Parkinson’s disease

(2013) Iciar Aviles-Olmos et al.   JOURNAL OF CLINICAL INVESTIGATION

2-Aminoadipic acid is a biomarker for diabetes risk

(2013) Thomas J. Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Looking back into the future: 30 years of metabolomics at TNO

(2013) Jan van der Greef et al.   MASS SPECTROMETRY REVIEWS

Insulin Resistance and Dysregulation of Tryptophan–Kynurenine and Kynurenine–Nicotinamide Adenine Dinucleotide Metabolic Pathways

(2013) Gregory Oxenkrug   MOLECULAR NEUROBIOLOGY

3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis

(2013) Peter A. LeWitt et al.   MOVEMENT DISORDERS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

(2013) Laura Dunn et al.   NEUROBIOLOGY OF AGING

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome

(2013) Lee D Roberts et al.   Lancet Diabetes & Endocrinology

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

(2012) Markus Otto et al.   Amyotrophic Lateral Sclerosis

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations

(2012) Lin Tan et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

(2012) Christian Czech et al.   PLoS One

EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force

(2011) et al.   EUROPEAN JOURNAL OF NEUROLOGY

ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations

(2011) Anna Wuolikainen et al.   MOLECULAR GENETICS AND METABOLISM

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

Family history of neurodegenerative and vascular diseases in ALS: A population-based study

(2011) M. H. B. Huisman et al.   NEUROLOGY

Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS

(2011) Anna Wuolikainen et al.   PLoS One

Alteration of amino acids in cerebrospinal fluid from patients with Parkinson's disease and spinocerebellar degeneration

(2010) K. Araki et al.   ACTA NEUROLOGICA SCANDINAVICA

Impaired glucose tolerance in patients with amyotrophic lateral sclerosis

(2010) Pierre-Francois Pradat et al.   Amyotrophic Lateral Sclerosis

Decrease in Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Cerebrospinal Fluid during Elderly Aging and in Patients with Sporadic Form of Amyotrophic Lateral Sclerosis

(2010) Chiaki Isobe et al.   NEUROSIGNALS

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Metabolomic Characterization of Human Prostate Cancer Bone Metastases Reveals Increased Levels of Cholesterol

(2010) Elin Thysell et al.   PLoS One

Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS

(2009) Anna Wuolikainen et al.   Amyotrophic Lateral Sclerosis

Metabolomics: Moving to the Clinic

(2009) Anders Nordström et al.   Journal of Neuroimmune Pharmacology

High metabolic level in patients with familial amyotrophic lateral sclerosis

(2008) Benoit Funalot et al.   Amyotrophic Lateral Sclerosis

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

(2008) Qian Han et al.   BIOSCIENCE REPORTS

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE