Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

Neuroproteomics tools in clinical practice

(2015) Ganna Shevchenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS

(2015) Parvathi Menon et al.   CLINICAL NEUROPHYSIOLOGY

Comparative analysis of targeted metabolomics: Dominance-based rough set approach versus orthogonal partial least square-discriminant analysis

(2015) H. Blasco et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

(2015) Gabriel N. Valbuena et al.   MOLECULAR NEUROBIOLOGY

The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis

(2015) Elizabeth Gray et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Potential structural and functional biomarkers of upper motor neuron dysfunction in ALS

(2015) Stuart M. Grieve et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43

(2014) Archi Joardar et al.   HUMAN MOLECULAR GENETICS

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

(2014) Hiroshi Mitsumoto et al.   LANCET NEUROLOGY

Untargeted 1H-NMR metabolomics in CSF: Toward a diagnostic biomarker for motor neuron disease

(2014) H. Blasco et al.   NEUROLOGY

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics

(2014) Kay A. Lawton et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

(2014) Michael E. Bozik et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amino Acids as biomarkers in the SOD1G93A mouse model of ALS

(2013) Monica Bame et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolomics in Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis: An Untargeted Approach via High-Resolution Mass Spectrometry

(2013) Hélène Blasco et al.   JOURNAL OF PROTEOME RESEARCH

The cyanobacterial amino acid β-N-methylamino-l-alanine perturbs the intermediary metabolism in neonatal rats

(2013) Mikael K.R. Engskog et al.   TOXICOLOGY

Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS

(2013) Ettore Beghi et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

(2012) Markus Otto et al.   Amyotrophic Lateral Sclerosis

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical alterations associated with ALS

(2011) Kay A. Lawton et al.   Amyotrophic Lateral Sclerosis

ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations

(2011) Anna Wuolikainen et al.   MOLECULAR GENETICS AND METABOLISM

Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS

(2011) Anna Wuolikainen et al.   PLoS One

The application of biomarkers in clinical trials for motor neuron disease

(2010) Jeban Ganesalingam et al.   Biomarkers in Medicine

Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis

(2010) Alok Kumar et al.   CLINICA CHIMICA ACTA

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

(2010) Maud M. Koek et al.   Metabolomics

1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

(2010) Hélène Blasco et al.   PLoS One

Analytical Approaches to Metabolomics and Applications to Systems Biology

(2010) Jeffrey H. Wang et al.   SEMINARS IN NEPHROLOGY

Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS

(2009) Anna Wuolikainen et al.   Amyotrophic Lateral Sclerosis

Variability Analysis of Human Plasma and Cerebral Spinal Fluid Reveals Statistical Significance of Changes in Mass Spectrometry-Based Metabolomics Data

(2009) Bridgit Crews et al.   ANALYTICAL CHEMISTRY

Applying proteomics to the diagnosis and treatment of ALS and related diseases

(2009) Robert Bowser et al.   MUSCLE & NERVE

Branched-Chain Amino Acids Induce Neurotoxicity in Rat Cortical Cultures

(2009) Valentina Contrusciere et al.   NEUROTOXICITY RESEARCH

Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases

(2008) Hayrettin Tumani et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY