Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

(2016) H. Blasco et al.   EUROPEAN JOURNAL OF NEUROLOGY

Interleukin-6 as a Therapeutic Target

(2015) J.-F. Rossi et al.   CLINICAL CANCER RESEARCH

Biological follow-up in amyotrophic lateral sclerosis: decrease in creatinine levels and increase in ferritin levels predict poor prognosis

(2015) F. Patin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Disentangling the effects of tocilizumab on neutrophil survival and function

(2015) Timo Gaber et al.   IMMUNOLOGIC RESEARCH

Humoral factors in ALS patients during disease progression

(2015) Jared Ehrhart et al.   Journal of Neuroinflammation

The dual roles of immunity in ALS: Injury overrides protection

(2015) Benjamin J. Murdock et al.   NEUROBIOLOGY OF DISEASE

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial

(2015) Muhammad K. Rafiq et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions

(2014) Norihiro Nishimoto et al.   Modern Rheumatology

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Tocilizumab, a Proposed Therapy for the Cachexia of Interleukin6-Expressing Lung Cancer

(2014) Katsutoshi Ando et al.   PLoS One

A plural role for lipids in motor neuron diseases: energy, signaling and structure

(2014) Florent Schmitt et al.   Frontiers in Cellular Neuroscience

The Biology and Medical Implications of Interleukin-6

(2014) T. Tanaka et al.   Cancer Immunology Research

Lysine metabolism in mammalian brain: an update on the importance of recent discoveries

(2013) André Hallen et al.   AMINO ACIDS

Potential Role of Branched-Chain Amino Acid Catabolism in Regulating Fat Oxidation

(2013) Heikki Kainulainen et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Can IL-6 blockade rectify imbalance between Tregs and Th17 cells?

(2013) Toshio Tanaka   Immunotherapy

PRIMe Update: Innovative Content for Plant Metabolomics and Integration of Gene Expression and Metabolite Accumulation

(2013) Tetsuya Sakurai et al.   PLANT AND CELL PHYSIOLOGY

Interleukin-6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

(2013) A. Thiolat et al.   Arthritis & Rheumatology

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Relationships between Disease Progression and Serum Levels of Lipid, Urate, Creatinine and Ferritin in Japanese Patients with Amyotrophic Lateral Sclerosis: A Cross-Sectional Study

(2012) Ken Ikeda et al.   INTERNAL MEDICINE

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

(2012) Weihua Zhao et al.   NEUROBIOLOGY OF DISEASE

Peripheral nerve inflammation in ALS mice: cause or consequence

(2012) O. Kano et al.   NEUROLOGY

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Cytokines

(2011) Gerrit van Hall   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue

(2011) Kenneth R Feingold et al.   Innate Immunity

Urgently needed—biomarkers for amyotrophic lateral sclerosis

(2011) Albert C. Ludolph   Nature Reviews Neurology

MetPA: a web-based metabolomics tool for pathway analysis and visualization

(2010) J. Xia et al.   BIOINFORMATICS

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

(2010) Satoshi Hohki et al.   EXPERIMENTAL EYE RESEARCH

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Platelet Serotonin Level Predicts Survival in Amyotrophic Lateral Sclerosis

(2010) Luc Dupuis et al.   PLoS One

Early administration of IL-6RA does not prevent radiation-induced lung injury in mice

(2010) Toshiyuki Ogata et al.   Radiation Oncology

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

(2008) Minoru Fujimoto et al.   ARTHRITIS AND RHEUMATISM

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase

(2008) Keiichi Iwanami et al.   ARTHRITIS AND RHEUMATISM

CV-ANOVA for significance testing of PLS and OPLS® models

(2008) Lennart Eriksson et al.   JOURNAL OF CHEMOMETRICS

Elevated Inflammatory Markers in a Group of Amyotrophic Lateral Sclerosis Patients from Northern India

(2008) G. Nagesh Babu et al.   NEUROCHEMICAL RESEARCH

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2008) Rebecca Banerjee et al.   PLoS One

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA