The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

(2014) Niccolo Bolli et al.   Nature Communications

Improved risk stratification in myeloma using a microRNA-based classifier

(2013) Ping Wu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

(2013) Ng Shyh-Chang et al.   Cell Stem Cell

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

(2013) Debora Lika Makino et al.   NATURE

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

(2013) Hao-Ming Chang et al.   NATURE

Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target

(2013) R. Tomecki et al.   NUCLEIC ACIDS RESEARCH

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

(2012) B. A. Walker et al.   BLOOD

MYC addiction: a potential therapeutic target in MM

(2012) W. M. Kuehl et al.   BLOOD

The ribonuclease Dis3 is an essential regulator of the developmental transcriptome

(2012) Dezhi Hou et al.   BMC GENOMICS

MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC

(2012) D-J Min et al.   LEUKEMIA

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function

(2012) Daneen Schaeffer et al.   NUCLEIC ACIDS RESEARCH

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

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Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs

(2011) D. Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of RNA Degradation by the Eukaryotic Exosome

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The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

(2010) Rafal Tomecki et al.   EMBO JOURNAL

Dis3-like 1: a novel exoribonuclease associated with the human exosome

(2010) Raymond H J Staals et al.   EMBO JOURNAL

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits

(2010) D. L. Kiss et al.   RNA

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism

(2010) R. Tomecki et al.   RNA

The role of AUF1 in regulated mRNA decay

(2010) Frances M. Gratacós et al.   Wiley Interdisciplinary Reviews-RNA

Expression and activation of the reprogramming transcription factors

(2009) Jun Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Origins and activities of the eukaryotic exosome

(2009) S. Lykke-Andersen et al.   JOURNAL OF CELL SCIENCE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

(2009) John P Hagan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

(2009) Claudia Schneider et al.   NUCLEIC ACIDS RESEARCH

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE