C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

(2015) Matthias Thoms et al.   CELL

RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

(2015) Evangelos Pefanis et al.   CELL

Nucleolin: Dual roles in rDNA chromatin transcription

(2015) Nathalie Durut et al.   GENE

RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination

(2015) C. Marin-Vicente et al.   JOURNAL OF CELL SCIENCE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation

(2015) Takashi Sutani et al.   Nature Communications

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

(2015) Chiara Naro et al.   Frontiers in Genetics

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase

(2014) Benjamin Schuch et al.   EMBO JOURNAL

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA

(2014) N. Manfrini et al.   EMBO REPORTS

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

(2014) Kienan I. Savage et al.   MOLECULAR CELL

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

RRP6 from Trypanosoma brucei: Crystal Structure of the Catalytic Domain, Association with EAP3 and Activity towards Structured and Non-Structured RNA Substrates

(2014) Rosicler L. Barbosa et al.   PLoS One

Cleavage Factor I Links Transcription Termination to DNA Damage Response and Genome Integrity Maintenance in Saccharomyces cerevisiae

(2014) Hélène Gaillard et al.   PLoS Genetics

Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example

(2013) Giulia Antoniali et al.   ANTIOXIDANTS & REDOX SIGNALING

RNA decay machines: The exosome

(2013) Aleksander Chlebowski et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

(2013) P. Richard et al.   GENES & DEVELOPMENT

Assembly of the Yeast Exoribonuclease Rrp6 with Its Associated Cofactor Rrp47 Occurs in the Nucleus and Is Critical for the Controlled Expression of Rrp47

(2013) Monika Feigenbutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks

(2013) Inbal Mermershtain et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival

(2013) C. Naro et al.   NUCLEIC ACIDS RESEARCH

The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

(2013) Monika Feigenbutz et al.   PLoS One

Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair

(2013) M. Goldstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6

(2013) W. Garland et al.   RNA

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis

(2012) Hélène Gaillard et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A new PICTure of nucleolar stress

(2012) Akira Suzuki et al.   CANCER SCIENCE

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Posttranscriptional regulation of gene expression—adding another layer of complexity to the DNA damage response

(2012) Jorge Boucas et al.   Frontiers in Genetics

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA

(2011) Nicholas J. Watkins et al.   Wiley Interdisciplinary Reviews-RNA

Rrp47 and the function of the Sas10/C1D domain

(2010) Phil Mitchell   BIOCHEMICAL SOCIETY TRANSACTIONS

The C-terminal Region of the Exosome-associated Protein Rrp47 Is Specifically Required for Box C/D Small Nucleolar RNA 3′-Maturation

(2010) Joe L. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XPB Induces C1D Expression to Counteract UV-Induced Apoptosis

(2010) G. Li et al.   MOLECULAR CANCER RESEARCH

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Nucleolar targeting: the hub of the matter

(2009) Edward Emmott et al.   EMBO REPORTS

Architecture of the Smc5/6 Complex ofSaccharomyces cerevisiaeReveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6

(2009) Xinyuan Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In search of nonribosomal nucleolar protein function and regulation

(2009) Thoru Pederson et al.   JOURNAL OF CELL BIOLOGY

The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50†

(2008) Ross A. Edwards et al.   BIOCHEMISTRY

The 3' processing factor CstF functions in the DNA repair response

(2008) N. Mirkin et al.   NUCLEIC ACIDS RESEARCH

The exosome: a multipurpose RNA-decay machine

(2008) Manfred Schmid et al.   TRENDS IN BIOCHEMICAL SCIENCES