Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

(2015) Hemanth Tummala et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN)

(2015) Santhosh Dhanraj et al.   JOURNAL OF MEDICAL GENETICS

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

(2015) Bridget D Stuart et al.   NATURE GENETICS

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

(2015) Duy Nguyen et al.   Cell Reports

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome

(2014) Yasutaka Ueda et al.   BMC Medical Genetics

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion

(2014) S. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

3′ terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing

(2013) Katherine C Goldfarb et al.   BMC MOLECULAR BIOLOGY

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif

(2011) C. Rammelt et al.   RNA

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

(2008) Franck Gallardo et al.   EMBO JOURNAL

A sensitive direct human telomerase activity assay

(2008) Scott B Cohen et al.   NATURE METHODS

Dyskeratosis congenita: The diverse clinical presentation of mutations in the telomerase complex

(2007) T.J. Vulliamy et al.   BIOCHIMIE