The role of histidines in amyloid β fibril assembly

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ

(2016) Marty A. Fernandez et al.   BIOCHEMISTRY

Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer’s Disease Immunotherapy

(2016) Jing Liu et al.   DRUGS & AGING

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Physical determinants of the self-replication of protein fibrils

(2016) Anđela Šarić et al.   Nature Physics

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization

(2016) Andrey N. Istrate et al.   Scientific Reports

Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Yvonne S. Eisele et al.   ACTA NEUROPATHOLOGICA

Socio-economic Aspects of Alzheimer's Disease

(2015) Petra Maresova et al.   Current Alzheimer Research

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage

(2015) Yasuhiro Teranishi et al.   FEBS Journal

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer's amyloid β peptide

(2014) Shatera Tabassum et al.   FEBS Journal

Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production

(2014) Kia Strömberg et al.   FEBS Journal

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

(2014) Kristoffer Brännström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Generic Method for Design of Oligomer-Specific Antibodies

(2014) Kristoffer Brännström et al.   PLoS One

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis

(2013) Donna M Wilcock et al.   Journal of Neuroinflammation

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-dependence of the specific binding of Cu(II) and Zn(II) ions to the amyloid-β peptide

(2012) Leila Ghalebani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ca2+enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

(2012) Kristoffer Brännström et al.   BIOCHEMICAL JOURNAL

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

(2011) Kristoffer Brännström et al.   PLoS One

Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ1–42 peptide, synthesized by depsi-peptide technique

(2010) Matteo Stravalaci et al.   BIOSENSORS & BIOELECTRONICS

Amyloid-β Oligomer Specificity Mediated by the IgM Isotype – Implications for a Specific Protective Mechanism Exerted by Endogenous Auto-Antibodies

(2010) Malin Lindhagen-Persson et al.   PLoS One

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu2+or Zn2+

(2009) Anders Olofsson et al.   FEBS Journal