Multifaceted death receptor 3 signaling-promoting survival and triggering death

Death receptor 3 signaling enhances proliferation of human regulatory T cells

(2017) Sebastian Bittner et al.   FEBS LETTERS

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Crohn's disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells

(2017) Giorgos Bamias et al.   Translational Research

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion

(2017) Itay Levin et al.   PLoS One

Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease

(2016) William V. Perks et al.   AMERICAN JOURNAL OF PATHOLOGY

DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease

(2016) H. Nishikii et al.   BLOOD

Death receptor 3 mediates necroptotic cell death

(2016) Sebastian Bittner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD

(2016) Tomasz J. Slebioda et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Effect of infusion of monoclonal antibodies to tumour necrosis factor-receptor super family 25 on graft rejection in allo-immune mice receiving autologous marrow transplantation

(2016) Reginald M. Gorczynski et al.   IMMUNOLOGY

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis

(2016) Maninder Sidhu-Varma et al.   INFLAMMATORY BOWEL DISEASES

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection

(2016) Li-Guo Jia et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells: Differentiation and Function

(2016) G. Plitas et al.   Cancer Immunology Research

Secretion, blood levels and cutaneous expression of TL1A in psoriasis patients

(2015) Anders Elm Pedersen et al.   APMIS

Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease

(2015) B.-S. Kim et al.   BLOOD

Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation

(2015) Yong-Oon Ahn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble TL1A is sufficient for activation of death receptor 3

(2015) Sebastian Bittner et al.   FEBS Journal

The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells

(2015) Arianne C. Richard et al.   JOURNAL OF IMMUNOLOGY

The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases

(2015) Spyros I. Siakavellas et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia

(2015) Chiara Cavallini et al.   Oncotarget

TNF-like ligand 1A is associated with the pathogenesis of psoriasis vulgaris and contributes to IL-17 production in PBMCs

(2014) Lin Li et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality

(2014) P Holmkvist et al.   Mucosal Immunology

TL1A Increases Expression of CD25, LFA-1, CD134 and CD154, and Induces IL-22 and GM-CSF Production from Effector CD4 T-Cells

(2014) Kirsten Reichwald et al.   PLoS One

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

(2014) H. Morikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3

(2014) Eddie C. Y. Wang et al.   Arthritis & Rheumatology

Circulating levels of TNF-like cytokine 1A correlate with the progression of atheromatous lesions in patients with rheumatoid arthritis

(2013) G. Bamias et al.   CLINICAL IMMUNOLOGY

Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis

(2013) László Képíró et al.   HUMAN IMMUNOLOGY

Cloning, Expression, and Functional Characterization of TL1A-Ig

(2013) S. Q. Khan et al.   JOURNAL OF IMMUNOLOGY

TNF-like Ligand 1A (TL1A) Gene Knockout Leads to Ameliorated Collagen-Induced Arthritis in Mice: Implication of TL1A in Humoral Immune Responses

(2013) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis

(2013) Yoshihiro Aiba et al.   LIVER INTERNATIONAL

High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease

(2013) Lu Song et al.   MEDIATORS OF INFLAMMATION

TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

(2013) X Yu et al.   Mucosal Immunology

The TNF-Family Cytokine TL1A Inhibits Proliferation of Human Activated B Cells

(2013) Chiara Cavallini et al.   PLoS One

Elevated serum and synovial fluid TNF-like ligand 1A (TL1A) is associated with autoantibody production in patients with rheumatoid arthritis

(2013) X Sun et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population

(2012) Minoru Nakamura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Death receptor 3 is essential for generating optimal protective CD41 T-cell immunity against Salmonella

(2012) Sarah L. Buchan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity

(2012) Jason P. Twohig et al.   FASEB JOURNAL

A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohn's Disease in a Japanese Population

(2012) Keiko Yamazaki et al.   GASTROENTEROLOGY

Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα

(2012) Caroline Swan et al.   GUT

T Cell Costimulation by TNFR Superfamily (TNFRSF)4 and TNFRSF25 in the Context of Vaccination

(2012) T. H. Schreiber et al.   JOURNAL OF IMMUNOLOGY

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation

(2012) S Jin et al.   Mucosal Immunology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

An Essential Role for Death Receptor 3 in Experimental Autoimmune Uveoretinitis

(2012) Claudia J. Calder et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Increased levels of soluble TNF-like cytokine 1A in ankylosing spondylitis

(2012) M. Konsta et al.   RHEUMATOLOGY

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Tregs Expanded In Vivo by TNFRSF25 Agonists Promote Cardiac Allograft Survival

(2012) Dietlinde Wolf et al.   TRANSPLANTATION

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn's disease

(2011) Giorgos Bamias et al.   DIGESTIVE AND LIVER DISEASE

Triggering of TNFRSF25 promotes CD8+ T-cell responses and anti-tumor immunity

(2011) Tomasz J. Slebioda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Upregulation and nuclear localization of TNF-like Cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions

(2011) Giorgos Bamias et al.   EXPERIMENTAL DERMATOLOGY

TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation

(2011) Françoise Meylan et al.   IMMUNOLOGICAL REVIEWS

No association between TNFSF15 and IL23R with ulcerative colitis in Koreans

(2011) Suk-Kyun Yang et al.   JOURNAL OF HUMAN GENETICS

The Adaptor Protein TRADD Is Essential for TNF-Like Ligand 1A/Death Receptor 3 Signaling

(2011) Y. L. Pobezinskaya et al.   JOURNAL OF IMMUNOLOGY

Population-Specific Susceptibility to Crohn's Disease and Ulcerative Colitis; Dominant and Recessive Relative Risks in the Japanese Population

(2010) Shigeki Nakagome et al.   ANNALS OF HUMAN GENETICS

High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis

(2010) Giorgos Bamias et al.   CLINICAL IMMUNOLOGY

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

(2010) Gareth W. Jones et al.   FASEB JOURNAL

TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets

(2010) Stephanie C. Heidemann et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

(2010) Taylor H. Schreiber et al.   JOURNAL OF CLINICAL INVESTIGATION

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

(2010) F Meylan et al.   Mucosal Immunology

TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort

(2009) R Thiébaut et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

(2009) Hiroyuki Kayamuro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells

(2009) David Q. Shih et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohnʼs disease

(2009) Nobuhiko Kamada et al.   INFLAMMATORY BOWEL DISEASES

Role of TL1A in the Pathogenesis of Rheumatoid Arthritis

(2009) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY

Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis

(2008) Giorgos Bamias et al.   CLINICAL IMMUNOLOGY

Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization

(2008) Nicole Müller et al.   FEBS Journal

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

The TNF-Family Receptor DR3 is Essential for Diverse T Cell-Mediated Inflammatory Diseases

(2008) Françoise Meylan et al.   IMMUNITY

Contribution of TNFSF15 gene variants to Crohnʼs disease susceptibility confirmed in UK population

(2008) Mark Tremelling et al.   INFLAMMATORY BOWEL DISEASES

Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

(2008) Lei Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Death Receptor 3–TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis

(2008) Melanie Jane Bull et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A Both Promotes and Protects from Renal Inflammation and Injury

(2008) R. S. Al-Lamki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY