A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection

Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation

(2015) Yong-Oon Ahn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development of Inflammatory Bowel Disease in Long-Evans Cinnamon Rats Based on CD4+CD25+Foxp3+ Regulatory T Cell Dysfunction

(2014) N. Ishimaru et al.   JOURNAL OF IMMUNOLOGY

A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality

(2014) P Holmkvist et al.   Mucosal Immunology

The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation

(2013) Giorgos Bamias et al.   CURRENT OPINION IN GASTROENTEROLOGY

Immunobiology of TNFSF15 and TNFRSF25

(2013) Taylor H. Schreiber et al.   IMMUNOLOGIC RESEARCH

Cloning, Expression, and Functional Characterization of TL1A-Ig

(2013) S. Q. Khan et al.   JOURNAL OF IMMUNOLOGY

Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation

(2012) Franziska Boehm et al.   BMC GASTROENTEROLOGY

New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation

(2012) Giorgos Bamias et al.   CYTOKINE

Death receptor 3 is essential for generating optimal protective CD41 T-cell immunity against Salmonella

(2012) Sarah L. Buchan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity

(2012) Jason P. Twohig et al.   FASEB JOURNAL

Abatacept for Crohn's Disease and Ulcerative Colitis

(2012) William J. Sandborn et al.   GASTROENTEROLOGY

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation

(2012) S Jin et al.   Mucosal Immunology

Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn's disease

(2011) Giorgos Bamias et al.   DIGESTIVE AND LIVER DISEASE

TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation

(2011) Françoise Meylan et al.   IMMUNOLOGICAL REVIEWS

Innate Immune Activation in Intestinal Homeostasis

(2011) Oliver J. Harrison et al.   Journal of Innate Immunity

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis

(2011) David Q. Shih et al.   PLoS One

High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis

(2010) Giorgos Bamias et al.   CLINICAL IMMUNOLOGY

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

(2010) Gareth W. Jones et al.   FASEB JOURNAL

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

(2010) Taylor H. Schreiber et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia

(2010) V Y Taraban et al.   Mucosal Immunology

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

(2010) F Meylan et al.   Mucosal Immunology

TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort

(2009) R Thiébaut et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Role of TL1A in the Pathogenesis of Rheumatoid Arthritis

(2009) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Probiotics promote gut health through stimulation of epithelial innate immunity

(2009) C. Pagnini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of TNFSF15 With Crohn's Disease in Koreans

(2008) Suk-Kyun Yang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation

(2008) Lei Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A Both Promotes and Protects from Renal Inflammation and Injury

(2008) R. S. Al-Lamki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TNF Receptor Type I-Dependent Activation of Innate Responses to Reduce Intestinal Damage-Associated Mortality

(2007) Emiko Mizoguchi et al.   GASTROENTEROLOGY