Potential biomarkers to follow the progression and treatment response of Huntington’s disease

Reducing the risk of failure: biomarker-guided trial design

(2016) Michael J. Townsend et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease

(2015) S. Hwang et al.   EMBO Molecular Medicine

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

(2015) Marios Politis et al.   NEUROBIOLOGY OF DISEASE

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models

(2015) Ulrike Träger et al.   NEUROBIOLOGY OF DISEASE

The choreography of neuroinflammation in Huntington's disease

(2015) Andrea Crotti et al.   TRENDS IN IMMUNOLOGY

Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients

(2014) Irene Ciancarelli et al.   BIOMARKERS

Biomarker development for Huntington's disease

(2014) Ralph Andre et al.   DRUG DISCOVERY TODAY

Metabolism in HD: Still a relevant mechanism?

(2014) Wenzhen Duan et al.   MOVEMENT DISORDERS

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

(2013) Petar Podlesniy et al.   ANNALS OF NEUROLOGY

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

8OHdG is not a biomarker for Huntington disease state or progression

(2013) B. Borowsky et al.   NEUROLOGY

Circulating Mitochondrial DNA as Biomarker Linking Environmental Chemical Exposure to Early Preclinical Lesions Elevation of mtDNA in Human Serum after Exposure to Carcinogenic Halo-Alkane-Based Pesticides

(2013) Lygia T. Budnik et al.   PLoS One

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response

(2012) Timothy E. Shutt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shaping the role of mitochondria in the pathogenesis of Huntington's disease

(2012) Veronica Costa et al.   EMBO JOURNAL

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

8OHdG as a marker for Huntington disease progression

(2012) Jeffrey D. Long et al.   NEUROBIOLOGY OF DISEASE

Development of biomarkers for Huntington's disease

(2011) David W Weir et al.   LANCET NEUROLOGY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

(2010) J. Kim et al.   HUMAN MOLECULAR GENETICS

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer

(2009) Peng Xia et al.   BMC CANCER

Simultaneous quantitative assessment of circulating cell-free mitochondrial and nuclear DNA by multiplex real-time PCR

(2009) Peng Xia et al.   GENETICS AND MOLECULAR BIOLOGY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

(2009) Corina Kohler et al.   Molecular Cancer

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE