Drinking problems: mechanisms of macropinosome formation and maturation

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment

(2016) Shefali Krishna et al.   DEVELOPMENTAL CELL

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

(2016) Lee Dolat et al.   JOURNAL OF CELL BIOLOGY

Uses and abuses of macropinocytosis

(2016) Gareth Bloomfield et al.   JOURNAL OF CELL SCIENCE

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

ADiaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis

(2016) Alexander Junemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

(2016) Catherine M. Buckley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

A plasma membrane template for macropinocytic cups

(2016) Douwe M Veltman et al.   eLife

Macropinocytosis Exploitation by Cancers and Cancer Therapeutics

(2016) Kevin D. Ha et al.   Frontiers in Physiology

Molecular imaging analysis of Rab GTPases in the regulation of phagocytosis and macropinocytosis

(2015) Youhei Egami   ANATOMICAL SCIENCE INTERNATIONAL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole

(2015) Cheuk Y. Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells

(2015) Sayaka Yasuda et al.   JOURNAL OF CELL SCIENCE

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

(2015) Andreas Jeschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Phosphoinositide-Gated Lysosomal Ca2+Channel, TRPML1, Is Required for Phagosome Maturation

(2015) Roya M. Dayam et al.   TRAFFIC

Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

(2015) Gareth Bloomfield et al.   eLife

Macropinocytosis: a pathway to protozoan infection

(2015) Tecia M. U. de Carvalho et al.   Frontiers in Physiology

Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages

(2015) Sei Yoshida et al.   Frontiers in Physiology

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

(2015) Rafaa Zeineddine et al.   Frontiers in Physiology

The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells

(2015) Gerald R. V. Hammond et al.   PLoS One

The Mechanism of Phagocytosis: Two Stages of Engulfment

(2014) David M. Richards et al.   BIOPHYSICAL JOURNAL

Self-organization of protrusions and polarity during eukaryotic chemotaxis

(2014) Brian R Graziano et al.   CURRENT OPINION IN CELL BIOLOGY

PIP3-dependent macropinocytosis is incompatible with chemotaxis

(2014) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

(2014) M. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

(2014) Youhei Egami et al.   Frontiers in Physiology

Differential regulation of macropinocytosis in macrophages by cytokines: Implications for foam cell formation and atherosclerosis

(2013) Daryn R. Michael et al.   CYTOKINE

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Two distinct functions for PI3-kinases in macropinocytosis

(2013) O. Hoeller et al.   JOURNAL OF CELL SCIENCE

WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion

(2013) Jason S. King et al.   MOLECULAR BIOLOGY OF THE CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics

(2013) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation

(2013) Makoto Fujii et al.   Scientific Reports

Spatiotemporal Localization of Rab20 in Live RAW264 Macrophages during Macropinocytosis

(2012) Youhei Egami et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Gulping rather than sipping: macropinocytosis as a way of virus entry

(2012) Jason Mercer et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

(2012) Jan R T van Weering et al.   EMBO JOURNAL

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

(2012) Dave Bridges et al.   MOLECULAR BIOLOGY OF THE CELL

SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages

(2012) J. P. Lim et al.   Biology Open

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

(2011) Michael Carnell et al.   JOURNAL OF CELL BIOLOGY

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

(2011) Junya Hasegawa et al.   JOURNAL OF CELL BIOLOGY

Ruffles limit diffusion in the plasma membrane during macropinosome formation

(2011) T. P. Welliver et al.   JOURNAL OF CELL SCIENCE

Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages

(2011) Urszula Golebiewska et al.   MOLECULAR BIOLOGY OF THE CELL

Coordination of the Rab5 Cycle on Macropinosomes

(2011) William D. Feliciano et al.   TRAFFIC

SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation

(2011) Jan R.T. van Weering et al.   TRAFFIC

The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape

(2010) Sylvain Tollis et al.   BMC Systems Biology

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

Retrieval of the Vacuolar H+-ATPase from Phagosomes Revealed by Live Cell Imaging

(2010) Margaret Clarke et al.   PLoS One

The SNX-PX-BAR Family in Macropinocytosis: The Regulation of Macropinosome Formation by SNX-PX-BAR Proteins

(2010) Jack T. H. Wang et al.   PLoS One

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion

(2009) Arthur Millius et al.   CURRENT BIOLOGY

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

(2009) S. Yoshida et al.   JOURNAL OF CELL SCIENCE

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles

(2009) Emma L. Clayton et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic Changes in the Spatiotemporal Localization of Rab21 in Live RAW264 Cells during Macropinocytosis

(2009) Youhei Egami et al.   PLoS One

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

A role for SNX5 in the regulation of macropinocytosis

(2008) Jet Lim et al.   BMC CELL BIOLOGY

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

Combinatorial Targeting of the Macropinocytotic Pathway in Leukemia and Lymphoma Cells

(2008) Shinpei Nishimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Unique Platform for H-Ras Signaling Involving Clathrin-independent Endocytosis

(2007) Natalie Porat-Shliom et al.   MOLECULAR BIOLOGY OF THE CELL