An engineered photoswitchable mammalian pyruvate kinase

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

What Mutagenesis Can and Cannot Reveal About Allostery

(2016) Gerald M. Carlson et al.   BIOPHYSICAL JOURNAL

Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β -Cells

(2016) Matthew J. Merrins et al.   BIOPHYSICAL JOURNAL

Protein Allostery and Conformational Dynamics

(2016) Jingjing Guo et al.   CHEMICAL REVIEWS

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy

(2016) Patrick E. Konold et al.   Journal of Physical Chemistry Letters

Engineering extrinsic disorder to control protein activity in living cells

(2016) Onur Dagliyan et al.   SCIENCE

Systems-level analysis of mechanisms regulating yeast metabolic flux

(2016) S. R. Hackett et al.   SCIENCE

Allostery: An Overview of Its History, Concepts, Methods, and Applications

(2016) Jin Liu et al.   PLoS Computational Biology

Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication

(2016) Enrico Guarnera et al.   PLoS Computational Biology

Design of Allosterically Regulated Protein Catalysts

(2015) Olga V. Makhlynets et al.   BIOCHEMISTRY

Allostery without a conformational change? Revisiting the paradigm

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

The Evolution and Functional Role of Flavin-based Prokaryotic Photoreceptors

(2015) Aba Losi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell Metabolism

(2014) Byron DeLaBarre et al.   CHEMISTRY & BIOLOGY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

The role of distant mutations and allosteric regulation on LovD active site dynamics

(2014) Gonzalo Jiménez-Osés et al.   Nature Chemical Biology

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

(2013) James I MacRae et al.   BMC BIOLOGY

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity

(2013) Matthew J. Merrins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Flavin-Based Fluorescent Proteins: An Emerging Class of Fluorescent Reporters

(2013) Arnab Mukherjee et al.   PLoS One

Fluorescence Imaging-Based High-Throughput Screening of Fast- and Slow-Cycling LOV Proteins

(2013) Fuun Kawano et al.   PLoS One

Functioning of a metabolic flux sensor in Escherichia coli

(2013) K. Kochanowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

The Evolution of Flavin-Binding Photoreceptors: An Ancient Chromophore Serving Trendy Blue-Light Sensors

(2012) Aba Losi et al.   Annual Review of Plant Biology

Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation

(2012) Yi-Fan Xu et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

(2012) M. Cortes-Cros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Hot Spots for Allosteric Regulation on Protein Surfaces

(2011) Kimberly A. Reynolds et al.   CELL

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Function, structure and mechanism of bacterial photosensory LOV proteins

(2011) Julien Herrou et al.   NATURE REVIEWS MICROBIOLOGY

Glycolytic Oscillations and Limits on Robust Efficiency

(2011) F. A. Chandra et al.   SCIENCE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2010) Jian-kang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rationally improving LOV domain–based photoswitches

(2010) Devin Strickland et al.   NATURE METHODS

Mechanism of signal transduction of the LOV2-Jα photosensor from Avena sativa

(2010) Emanuel Peter et al.   Nature Communications

An Activating Interaction between the Unphosphorylated N-Terminus of Human Liver Pyruvate Kinase and the Main Body of the Protein Is Interrupted by Phosphorylation

(2009) Aron W. Fenton et al.   BIOCHEMISTRY

Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes

(2009) Jeanne A. Hardy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

The photoreversible fluorescent protein iLOV outperforms GFP as a reporter of plant virus infection

(2008) S. Chapman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES