Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet β-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

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A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

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M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

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Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism

(2012) Matthew J. Merrins et al.   PLoS One

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes

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Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic  -Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3

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Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells

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An Improved Cerulean Fluorescent Protein with Enhanced Brightness and Reduced Reversible Photoswitching

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Engineering Genetically Encoded Nanosensors for Real-Time In Vivo Measurements of Citrate Concentrations

(2011) Jennifer C. Ewald et al.   PLoS One

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Metabolic Oscillations in Pancreatic Islets Depend on the Intracellular Ca2+ Level but Not Ca2+ Oscillations

(2010) Matthew J. Merrins et al.   BIOPHYSICAL JOURNAL

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein Markers for Insulin-Producing Beta Cells with Higher Glucose Sensitivity

(2010) Geert A. Martens et al.   PLoS One

Using phase relations to identify potential mechanisms for metabolic oscillations in isolated β-cell mitochondria

(2010) Richard Bertram et al.   Islets

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

(2009) Abdellah Allali-Hassani et al.   BIOCHEMICAL JOURNAL

A Model of Action Potentials and Fast Ca2+ Dynamics in Pancreatic β-Cells

(2009) L.E. Fridlyand et al.   BIOPHYSICAL JOURNAL

Anomalous Surplus Energy Transfer Observed with Multiple FRET Acceptors

(2009) Srinagesh V. Koushik et al.   PLoS One

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE