TGF-β& BMP Receptors Endoglin and ALK1: Overview of their Functional Role and Status as Antiangiogenic Targets

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy

(2013) Lukas JAC Hawinkels et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Endoglin for tumor imaging and targeted cancer therapy

(2013) Madelon Paauwe et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-  signaling pathways

(2013) S. Park et al.   JOURNAL OF CELL SCIENCE

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activin Receptor-Like Kinase 1: a Novel Anti-angiogenesis Target from TGF-β Family

(2013) Luca Vecchia et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Abstract 3276: A Phase 1 dose escalating study with ACE-041, a novel inhibitor of ALK1 mediated angiogenesis, in patients with advanced solid tumors

(2012) Johanna C. Bendell et al.   CANCER RESEARCH

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

(2012) Laurens A. van Meeteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies

(2012) Olivier Nolan-Stevaux et al.   PLoS One

ALK1 as an emerging target for antiangiogenic therapy of cancer

(2011) S. I. Cunha et al.   BLOOD

Targeting Activin Receptor-Like Kinase 1 Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies

(2011) Dana D. Hu-Lowe et al.   CANCER RESEARCH

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

(2010) Y. Suzuki et al.   JOURNAL OF CELL SCIENCE

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

(2010) Sara I. Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

Endoglin-Targeted Cancer Therapy

(2010) Ben K. Seon et al.   Current Drug Delivery

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

(2009) E. S. Shao et al.   BLOOD

Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours

(2009) E. Fonsatti et al.   CARDIOVASCULAR RESEARCH

Hereditary haemorrhagic telangiectasia: a clinical and scientific review

(2009) Fatima S Govani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature

(2009) Shima Uneda et al.   INTERNATIONAL JOURNAL OF CANCER

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistance to targeted therapy in renal-cell carcinoma

(2009) Brian I Rini et al.   LANCET ONCOLOGY

HHT is not a TGF disease

(2008) S. Bailly   BLOOD

Regulating the stability of TGFβ receptors and Smads

(2008) Peter Lönn et al.   CELL RESEARCH

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH