PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis

Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

(2016) Zachary R Schoepflin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study

(2016) Shuai Chen et al.   LABORATORY INVESTIGATION

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

Early development of the vertebral column

(2016) Martin Scaal   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells

(2016) Raymond H. de Wit et al.   Oncotarget

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

(2016) Javier Rodriguez et al.   Cell Reports

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus

(2015) Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function

(2015) Ying Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban

(2015) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lack of Evidence for PKM2 Protein Kinase Activity

(2015) Aaron M. Hosios et al.   MOLECULAR CELL

A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia

(2015) Dong Joon Kim et al.   MOLECULES AND CELLS

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

(2015) Elisa Giannoni et al.   Oncotarget

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells

(2014) Yuichiro Hirose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3-SUMO conjugation represses HIF1 transcriptional activity independently of PHD3 catalytic activity

(2014) A. Nunez-O'Mara et al.   JOURNAL OF CELL SCIENCE

Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions

(2014) Lija Swain et al.   JOURNAL OF LEUKOCYTE BIOLOGY

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

(2014) H Lincet et al.   ONCOGENE

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

(2014) Christophe Merceron et al.   PLoS One

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

(2014) Anne-Theres Henze et al.   Nature Communications

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

(2013) Sandra C. Moser et al.   DEVELOPMENTAL CELL

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase   Ubiquitination

(2013) J. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

(2012) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

(2011) Nobuyuki Fujita et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

(2010) Jens Leander Johansen et al.   JOURNAL OF NEUROCHEMISTRY

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY