Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases

(2014) Demissew S. Mern et al.   PLoS One

EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase   Ubiquitination

(2013) J. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches

(2013) Demissew S. Mern et al.   PLoS One

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

(2012) F. K. Pientka et al.   JOURNAL OF CELL SCIENCE

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

(2011) Nobuyuki Fujita et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α independent manner

(2011) Andree Yeramian et al.   LABORATORY INVESTIGATION

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

(2011) Emily Hams et al.   SHOCK

Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway

(2010) Jian Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

(2010) Jens Leander Johansen et al.   JOURNAL OF NEUROCHEMISTRY

ADAMTS-5 and Intervertebral Disc Degeneration: The Results of Tissue Immunohistochemistry and In Vitro Cell Culture

(2010) Chang-Qing Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration

(2009) S Jane Millward-Sadler et al.   ARTHRITIS RESEARCH & THERAPY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL