Multifactorial level of extremostability of proteins: can they be exploited for protein engineering?

Systems biology of the structural proteome

(2016) Elizabeth Brunk et al.   BMC Systems Biology

Enhancing the Thermostability of Serratia plymuthica Sucrose Isomerase Using B-Factor-Directed Mutagenesis

(2016) Xuguo Duan et al.   PLoS One

Diversity and industrial potential of hydrolase-producing halophilic/halotolerant eubacteria

(2016) Evodia Setati Mathabatha   AFRICAN JOURNAL OF BIOTECHNOLOGY

Hydration and Ion Binding of the Osmolyte Ectoine

(2015) Andreas Eiberweiser et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein Thermostability Is Owing to Their Preferences to Non-Polar Smaller Volume Amino Acids, Variations in Residual Physico-Chemical Properties and More Salt-Bridges

(2015) Anindya Sundar Panja et al.   PLoS One

Thermodynamics of protein denaturation at temperatures over 100 °C: CutA1 mutant proteins substituted with hydrophobic and charged residues

(2015) Yoshinori Matsuura et al.   Scientific Reports

Structural Rigidity and Protein Thermostability in Variants of Lipase A from Bacillus subtilis

(2015) Prakash Chandra Rathi et al.   PLoS One

Engineering Proteins for Thermostability with iRDP Web Server

(2015) Priyabrata Panigrahi et al.   PLoS One

A new acidophilic thermostable endo-1,4-β-mannanase from Penicillium oxalicum GZ-2: cloning, characterization and functional expression in Pichia pastoris

(2014) Hanpeng Liao et al.   BMC BIOTECHNOLOGY

NeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation

(2014) Manuel Giollo et al.   BMC GENOMICS

Enhanced Enzyme Kinetic Stability by Increasing Rigidity within the Active Site

(2014) Yuan Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salt-Bridge Energetics in Halophilic Proteins

(2014) Arnab Nayek et al.   PLoS One

Computational Design of a pH Stable Enzyme: Understanding Molecular Mechanism of Penicillin Acylase's Adaptation to Alkaline Conditions

(2014) Dmitry Suplatov et al.   PLoS One

Biochemical Properties of Ectoine Hydroxylases from Extremophiles and Their Wider Taxonomic Distribution among Microorganisms

(2014) Nils Widderich et al.   PLoS One

Thermostability of In Vitro Evolved Bacillus subtilis Lipase A: A Network and Dynamics Perspective

(2014) Ashutosh Srivastava et al.   PLoS One

A Coarse-Grained Elastic Network Atom Contact Model and Its Use in the Simulation of Protein Dynamics and the Prediction of the Effect of Mutations

(2014) Vincent Frappier et al.   PLoS Computational Biology

Dinosolve: a protein disulfide bonding prediction server using context-based features to enhance prediction accuracy

(2013) Ashraf Yaseen et al.   BMC BIOINFORMATICS

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma

(2013) Peikai Chen et al.   BMC BIOINFORMATICS

Comparative molecular dynamics simulation studies for determining factors contributing to the thermostability of chemotaxis protein “CheY”

(2013) Manish Paul et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Dynamics Perspective on the Protein Thermal Stability: A Case Study Using SAICAR Synthetase

(2013) Kavyashree Manjunath et al.   Journal of Chemical Information and Modeling

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparative Analysis of Barophily-Related Amino Acid Content in Protein Domains ofPyrococcus abyssiandPyrococcus furiosus

(2013) Liudmila S. Yafremava et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Protein Adaptations in Archaeal Extremophiles

(2013) Christopher J. Reed et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Cooperation between Catalytic and DNA Binding Domains Enhances Thermostability and Supports DNA Synthesis at Higher Temperatures by Thermostable DNA Polymerases

(2012) Andrey R. Pavlov et al.   BIOCHEMISTRY

Role of disulfide bonds in conformational stability and folding of 5′-deoxy-5′-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus

(2012) Giovanna Cacciapuoti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

High-throughput screening of B factor saturation mutated Rhizomucor miehei lipase thermostability based on synthetic reaction

(2012) Jun-hui Zhang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Structure-based engineering of histidine residues in the catalytic domain of α-amylase from Bacillus subtilis for improved protein stability and catalytic efficiency under acidic conditions

(2012) Haiquan Yang et al.   JOURNAL OF BIOTECHNOLOGY

The C-terminal sterile alpha motif (SAM) domain of human p73 is a highly dynamic protein, which acquires high thermal stability through a decrease in backbone flexibility

(2012) José L. Neira et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes

(2012) Yunqi Li et al.   PLoS One

Acidophilic bacteria and archaea: acid stable biocatalysts and their potential applications

(2011) Archana Sharma et al.   EXTREMOPHILES

Glycosylation Increases the Thermostability of Human Aquaporin 10 Protein

(2011) Fredrik Öberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new hybrid fractal algorithm for predicting thermophilic nucleotide sequences

(2011) Jin-Long Lu et al.   JOURNAL OF THEORETICAL BIOLOGY

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

Stabilizing Salt-Bridge Enhances Protein Thermostability by Reducing the Heat Capacity Change of Unfolding

(2011) Chi-Ho Chan et al.   PLoS One

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface

(2011) Alessandro Siglioccolo et al.   BMC STRUCTURAL BIOLOGY

Stability of domain structures in multi-domain proteins

(2011) Ramachandra M. Bhaskara et al.   Scientific Reports

Widespread Disulfide Bonding in Proteins from Thermophilic Archaea

(2011) Julien Jorda et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Protein Thermostability Calculations Using Alchemical Free Energy Simulations

(2010) Daniel Seeliger et al.   BIOPHYSICAL JOURNAL

Ectoines in cell stress protection: Uses and biotechnological production

(2010) José M. Pastor et al.   BIOTECHNOLOGY ADVANCES

Predicting changes in protein thermostability brought about by single- or multi-site mutations

(2010) Jian Tian et al.   BMC BIOINFORMATICS

Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins

(2010) Jun Okada et al.   BMC EVOLUTIONARY BIOLOGY

Sequence feature-based prediction of protein stability changes upon amino acid substitutions

(2010) Shaolei Teng et al.   BMC GENOMICS

Industrial applications of alkaliphiles and their enzymes – past, present and future

(2010) Shun Fujinami et al.   ENVIRONMENTAL TECHNOLOGY

In silico characterization of thermostable lipases

(2010) Debamitra Chakravorty et al.   EXTREMOPHILES

Performance of protein stability predictors

(2010) Sofia Khan et al.   HUMAN MUTATION

Improvement of  29 DNA polymerase amplification performance by fusion of DNA binding motifs

(2010) M. de Vega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An additional aromatic interaction improves the thermostability and thermophilicity of a mesophilic family 11 xylanase: Structural basis and molecular study

(2010) Jacques Georis et al.   PROTEIN SCIENCE

PROMOTIF-A program to identify and analyze structural motifs in proteins

(2010) E. Gail Hutchinson et al.   PROTEIN SCIENCE

Reliable prediction of protein thermostability change upon double mutation from amino acid sequence

(2009) Liang-Tsung Huang et al.   BIOINFORMATICS

Fast and accurate predictions of protein stability changes upon mutations using statistical potentials and neural networks: PoPMuSiC-2.0

(2009) Yves Dehouck et al.   BIOINFORMATICS

A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreus infaustus): insights into avian genome evolution

(2009) Sonja Jaari et al.   BMC GENOMICS

Effect of Ions on the Structure of Water: Structure Making and Breaking

(2009) Yizhak Marcus   CHEMICAL REVIEWS

Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus

(2009) Pompea Del Vecchio et al.   EXTREMOPHILES

Crystal Structure of a Thermophilic GrpE Protein: Insight into Thermosensing Function for the DnaK Chaperone System

(2009) Akira Nakamura et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of the Compatible Solute Ectoine in Virgibacillus pantothenticus Is Triggered by High Salinity and Low Growth Temperature

(2008) A. U. Kuhlmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Design of stability at extreme alkaline pH in streptococcal protein G

(2008) B PALMER et al.   JOURNAL OF BIOTECHNOLOGY

Predicting free energy changes using structural ensembles

(2008) Alexander Benedix et al.   NATURE METHODS

Neutralism and selectionism: a network-based reconciliation

(2008) Andreas Wagner   NATURE REVIEWS GENETICS

Effect of glycosylation on protein folding: A close look at thermodynamic stabilization

(2008) D. Shental-Bechor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of halophilic enzymes: Two acidic amino acid residues at the carboxy-terminal region confer halophilic characteristics toHalomonasandPseudomonasnucleoside diphosphate kinases

(2008) Hiroko Tokunaga et al.   PROTEIN SCIENCE

Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes

(2008) Sandip Paul et al.   GENOME BIOLOGY

Amino acid and codon usage profiles: Adaptive changes in the frequency of amino acids and codons

(2007) Hani Goodarzi et al.   GENE