Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models

Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine

(2016) Venkateswarlu Chamcha et al.   Open Forum Infectious Diseases

HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials

(2015) Nittaya Phanuphak et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection

(2015) Jerome H. Kim et al.   Annual Review of Medicine

Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+and CXCR5−CD4 T Cell Responses in Rhesus Macaques

(2015) Smita S. Iyer et al.   JOURNAL OF IMMUNOLOGY

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

(2015) Beatriz Mothe et al.   Journal of Translational Medicine

CD40L-Adjuvanted DNA/Modified Vaccinia Virus Ankara Simian Immunodeficiency Virus (SIV) Vaccine Enhances Protection against Neutralization-Resistant Mucosal SIV Infection

(2015) Suefen Kwa et al.   JOURNAL OF VIROLOGY

Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses

(2015) Samantha L. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection

(2015) Timothy R. Fouts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Priming with a Simplified Intradermal HIV-1 DNA Vaccine Regimen followed by Boosting with Recombinant HIV-1 MVA Vaccine Is Safe and Immunogenic: A Phase IIa Randomized Clinical Trial

(2015) Patricia. J. Munseri et al.   PLoS One

Potent Functional Antibody Responses Elicited by HIV-I DNA Priming and Boosting with Heterologous HIV-1 Recombinant MVA in Healthy Tanzanian Adults

(2015) Agricola Joachim et al.   PLoS One

Nonneutralizing Functional Antibodies: a New “Old” Paradigm for HIV Vaccines

(2014) Jean-Louis Excler et al.   Clinical and Vaccine Immunology

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

(2014) Masashi Shingai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody to the gp120 V1/V2 Loops and CD4+and CD8+T Cell Responses in Protection from SIVmac251Vaginal Acquisition and Persistent Viremia

(2014) Shari N. Gordon et al.   JOURNAL OF IMMUNOLOGY

Specificity and 6-Month Durability of Immune Responses Induced by DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-Like Particles

(2014) Paul A. Goepfert et al.   JOURNAL OF INFECTIOUS DISEASES

Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens

(2014) J. Garcia-Arriaza et al.   JOURNAL OF VIROLOGY

Local Control of Repeated-Dose Rectal Challenges in DNA/MVA-Vaccinated Macaques Protected against a First Series of Simian Immunodeficiency Virus Challenges

(2014) S. Kannanganant et al.   JOURNAL OF VIROLOGY

CD40L-Adjuvanted DNA/Modified Vaccinia Virus Ankara Simian Immunodeficiency Virus SIV239 Vaccine Enhances SIV-Specific Humoral and Cellular Immunity and Improves Protection against a Heterologous SIVE660 Mucosal Challenge

(2014) S. Kwa et al.   JOURNAL OF VIROLOGY

Antibody persistence and T-cell balance: Two key factors confronting HIV vaccine development

(2014) G. K. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 vaccines

(2014) Jean-Louis Excler et al.   Human Vaccines & Immunotherapeutics

Which Antibody Functions are Important for an HIV Vaccine?

(2014) Bin Su et al.   Frontiers in Immunology

Broad and Potent Cellular and Humoral Immune Responses After a Second Late HIV-Modified Vaccinia Virus Ankara Vaccination in HIV-DNA-Primed and HIV-Modified Vaccinia Virus Ankara-Boosted Swedish Vaccinees

(2013) Charlotta Nilsson et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Safety and Immunogenicity of DNA Prime and Modified Vaccinia Ankara Virus-HIV Subtype C Vaccine Boost in Healthy Adults

(2013) Peter Hayes et al.   Clinical and Vaccine Immunology

Synthetic DNA vaccine strategies against persistent viral infections

(2013) Daniel O Villarreal et al.   Expert Review of Vaccines

Resistance to Infection, Early and Persistent Suppression of Simian Immunodeficiency Virus SIVmac251 Viremia, and Significant Reduction of Tissue Viral Burden after Mucosal Vaccination in Female Rhesus Macaques

(2013) M. Manrique et al.   JOURNAL OF VIROLOGY

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of DNA and MVA HIV-1 Subtype C Vaccine Prime-Boost Regimens: A Phase I Randomised Trial in HIV-Uninfected Indian Volunteers

(2013) Sanjay Mehendale et al.   PLoS One

Recombinant MVA vaccines: dispelling the myths

(2013) Matthew G. Cottingham et al.   VACCINE

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants

(2013) Seleeke Flingai et al.   Frontiers in Immunology

The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120

(2012) Nicos Karasavvas et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A Blueprint for HIV Vaccine Discovery

(2012) Dennis R. Burton et al.   Cell Host & Microbe

Non-neutralizing antibodies in prevention of HIV infection

(2012) Harriet L. Robinson   EXPERT OPINION ON BIOLOGICAL THERAPY

Technologies for enhanced efficacy of DNA vaccines

(2012) Fadi Saade et al.   Expert Review of Vaccines

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial

(2012) Poonam Pegu et al.   JOURNAL OF VIROLOGY

Deletion of Specific Immune-Modulatory Genes from Modified Vaccinia Virus Ankara-Based HIV Vaccines Engenders Improved Immunogenicity in Rhesus Macaques

(2012) D. A. Garber et al.   JOURNAL OF VIROLOGY

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein

(2012) Juliana Falivene et al.   PLoS One

Heterologous Prime-Boost Regimens Using rAd35 and rMVA Vectors Elicit Stronger Cellular Immune Responses to HIV Proteins Than Homologous Regimens

(2012) Silvia Ratto-Kim et al.   PLoS One

Deletion of the Viral Anti-Apoptotic Gene F1L in the HIV/AIDS Vaccine Candidate MVA-C Enhances Immune Responses against HIV-1 Antigens

(2012) Beatriz Perdiguero et al.   PLoS One

The origin and diversity of the HIV-1 pandemic

(2012) Joris Hemelaar   TRENDS IN MOLECULAR MEDICINE

Inclusion of a CRF01_AE HIV envelope protein boost with a DNA/MVA prime-boost vaccine: Impact on humoral and cellular immunogenicity and viral load reduction after SHIV-E challenge

(2012) Josephine H. Cox et al.   VACCINE

Immunization with Multiple Vaccine Modalities Induce Strong HIV-Specific Cellular and Humoral Immune Responses

(2012) David Hallengärd et al.   VIRAL IMMUNOLOGY

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

(2012) Michael D. Alpert et al.   PLoS Pathogens

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Long-Term Control of Simian Immunodeficiency Virusmac251 Viremia to Undetectable Levels in Half of Infected Female Rhesus Macaques Nasally Vaccinated with Simian Immunodeficiency Virus DNA/Recombinant Modified Vaccinia Virus Ankara

(2011) M. Manrique et al.   JOURNAL OF IMMUNOLOGY

Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles

(2011) Paul A. Goepfert et al.   JOURNAL OF INFECTIOUS DISEASES

Prevention of Infection by a Granulocyte-Macrophage Colony-Stimulating Factor Co-Expressing DNA/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine

(2011) Lilin Lai et al.   JOURNAL OF INFECTIOUS DISEASES

Adenovirus type 5 induces vitamin A-metabolizing enzymes in dendritic cells and enhances priming of gut-homing CD8 T cells

(2011) S Ganguly et al.   Mucosal Immunology

In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers

(2011) Sandhya Vasan et al.   PLoS One

A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses

(2011) Juan García-Arriaza et al.   PLoS One

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

(2011) D. R. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching

(2011) Kristina E. Rehm et al.   VACCINE

Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania

(2011) Muhammad Bakari et al.   VACCINE

SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses

(2011) Lilin Lai et al.   VACCINE

Strong HIV-Specific CD4+ and CD8+ T-Lymphocyte Proliferative Responses in Healthy Individuals Immunized with an HIV-1 DNA Vaccine and Boosted with Recombinant Modified Vaccinia Virus Ankara Expressing HIV-1 Genes

(2010) S. Aboud et al.   Clinical and Vaccine Immunology

Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV

(2010) Monica Vaccari et al.   Expert Review of Vaccines

Mechanisms that determine plasma cell lifespan and the duration of humoral immunity

(2010) Ian J. Amanna et al.   IMMUNOLOGICAL REVIEWS

Preexisting Vaccinia Virus Immunity Decreases SIV-Specific Cellular Immunity but Does Not Diminish Humoral Immunity and Efficacy of a DNA/MVA Vaccine

(2010) S. Kannanganat et al.   JOURNAL OF IMMUNOLOGY

Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques

(2010) P. Xiao et al.   JOURNAL OF VIROLOGY

Immunogenic Profiling in Mice of a HIV/AIDS Vaccine Candidate (MVA-B) Expressing Four HIV-1 Antigens and Potentiation by Specific Gene Deletions

(2010) Juan García-Arriaza et al.   PLoS One

A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C-Modified Vaccinia Ankara Virus Vaccine Candidate in Indian Volunteers

(2009) Vadakkuppatu Devasenapathi Ramanathan et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

DNA Vaccination with Electroporation Induces Increased Antibody Responses in Patients with Prostate Cancer

(2009) Lindsey Low et al.   HUMAN GENE THERAPY

Mucosal Immunity and Protection Against HIV/SIV Infection: Strategies and Challenges for Vaccine Design

(2009) Thorsten Demberg et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines

(2009) R. H. Florese et al.   JOURNAL OF IMMUNOLOGY

Elucidating and Minimizing the Loss by Recombinant Vaccinia Virus of Human Immunodeficiency Virus Gene Expression Resulting from Spontaneous Mutations and Positive Selection

(2009) L. S. Wyatt et al.   JOURNAL OF VIROLOGY

Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination

(2009) M Manrique et al.   Mucosal Immunology

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smallpox vaccines for biodefense

(2009) Richard B. Kennedy et al.   VACCINE

A randomized, double-blind, dose-finding Phase II study to evaluate immunogenicity and safety of the third generation smallpox vaccine candidate IMVAMUNE®

(2009) Alfred von Krempelhuber et al.   VACCINE

Autocrine Production of β-Chemokines Protects CMV-Specific CD4+ T Cells from HIV Infection

(2009) Joseph P. Casazza et al.   PLoS Pathogens

Construction, Characterization, and Immunogenicity of a Multigene Modified Vaccinia Ankara (MVA) Vaccine Based on HIV Type 1 Subtype C

(2008) Wendy A. Burgers et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Broad Immunogenicity of a Multigene, Multiclade HIV‐1 DNA Vaccine Boosted with Heterologous HIV‐1 Recombinant Modified Vaccinia Virus Ankara

(2008) Eric Sandström et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Lessons from IAVI-006, a Phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers

(2008) A. Guimarães-Walker et al.   VACCINE

Generation of functionally active HIV-1 specific CD8+ CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization

(2008) Igor M. Belyakov et al.   VIROLOGY

Enhanced cell surface expression, immunogenicity and genetic stability resulting from a spontaneous truncation of HIV Env expressed by a recombinant MVA

(2007) Linda S. Wyatt et al.   VIROLOGY