Pneumococcal whole-cell and protein-based vaccines: changing the paradigm

Regulating vaccines at the FDA: development and licensure of Zika vaccines

(2017) Marion F. Gruber et al.   Expert Review of Vaccines

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

(2017) David J. Dowling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vaccine nanoparticles for protection against HIV infection

(2017) Marisa E Aikins et al.   Nanomedicine

The rise and fall of pneumococcal serotypes carried in the PCV era

(2017) Vanessa T. Devine et al.   VACCINE

IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine

(2017) Ivana B. Campos et al.   VACCINE

Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis

(2017) Melissa H. Chai et al.   Scientific Reports

Analysis of novel meningococcal vaccine formulations

(2017) Susu M. Zughaier   Human Vaccines & Immunotherapeutics

Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens

(2017) Robert Wilson et al.   PLoS Pathogens

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

(2016) Ilias Galanis et al.   EUROPEAN RESPIRATORY JOURNAL

Pertussis: acellular, whole-cell, new vaccines, what to choose?

(2016) Camille Locht   Expert Review of Vaccines

Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection

(2016) M. Nadeem Khan et al.   INFECTION AND IMMUNITY

Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants

(2016) Michael E. Pichichero et al.   JOURNAL OF INFECTIOUS DISEASES

Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY

(2016) Michael E. Pichichero   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Ten-Year Study of Acute Otitis Media in Rochester, NY

(2016) Michael E. Pichichero   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Modeling pneumococcal nasopharyngeal acquisition as a function of anticapsular serum antibody concentrations after pneumococcal conjugate vaccine administration

(2016) Ron Dagan et al.   VACCINE

Serotypes, antimicrobial susceptibility, and molecular epidemiology of invasive and non-invasive Streptococcus pneumoniae isolates in paediatric patients after the introduction of 13-valent conjugate vaccine in a nationwide surveillance study conducted in Japan in 2012–2014

(2016) Satoshi Nakano et al.   VACCINE

Status of research and development of pediatric vaccines for Streptococcus pneumoniae

(2016) Mark R. Alderson   VACCINE

Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?

(2016) Larry S. McDaniel et al.   mBio

Effectiveness of 13-valent pneumococcal conjugate vaccine for prevention of invasive pneumococcal disease in children in the USA: a matched case-control study

(2016) Matthew R Moore et al.   Lancet Respiratory Medicine

Insight Into Resistance Phenotypes of Emergent Non 13-valent Pneumococcal Conjugate Vaccine Type Pneumococci Isolated From Invasive Disease After 13-valent Pneumococcal Conjugate Vaccine Implementation in France

(2016) Claire Janoir et al.   Open Forum Infectious Diseases

Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study

(2015) Pauline A Waight et al.   LANCET INFECTIOUS DISEASES

Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young children

(2015) Q Xu et al.   Mucosal Immunology

Safety, Tolerability and Immunogenicity of 15-valent Pneumococcal Conjugate Vaccine in Toddlers Previously Vaccinated With 7-valent Pneumococcal Conjugate Vaccine

(2015) Ajoke Sobanjo-ter Meulen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Decreased Carriage and Genetic Shifts in the Streptococcus pneumoniae Population After Changing the Seven-valent to the Thirteen-valent Pneumococcal Vaccine in Norway

(2015) Anneke Steens et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reduced IL-17A Secretion Is Associated with High Levels of Pneumococcal Nasopharyngeal Carriage in Fijian Children

(2015) Edwin Hoe et al.   PLoS One

Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials

(2015) Isabel Leroux-Roels et al.   VACCINE

Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

(2015) W. Abdullah Brooks et al.   VACCINE

Safety, tolerability, and immunogenicity of 15-valent pneumococcal conjugate vaccine in healthy adults

(2015) Richard McFetridge et al.   VACCINE

Synchrony in serum antibody response to conserved proteins ofStreptococcus pneumoniaein young children

(2015) Dabin Ren et al.   Human Vaccines & Immunotherapeutics

Next generation protein basedStreptococcus pneumoniaevaccines

(2015) Michael E Pichichero et al.   Human Vaccines & Immunotherapeutics

Rationale and prospects for novel pneumococcal vaccines

(2015) Kristin Moffitt et al.   Human Vaccines & Immunotherapeutics

Reactogenicity, safety and immunogenicity of a protein-based pneumococcal vaccine in Gambian children aged 2–4 years: A phase II randomized study

(2015) A Odutola et al.   Human Vaccines & Immunotherapeutics

What to do about pertussis vaccines? Linking what we know about pertussis vaccine effectiveness, immunology and disease transmission to create a better vaccine: Graphical Abstract Figure.

(2015) Shelly Bolotin et al.   Pathogens and Disease

Randomized Controlled Study of the Safety and Immunogenicity of Pneumococcal Vaccine Formulations Containing PhtD and Detoxified Pneumolysin with Alum or Adjuvant System AS02Vin Elderly Adults

(2014) Karlis Pauksens et al.   Clinical and Vaccine Immunology

Differential Impact of Respiratory Syncytial Virus and Parainfluenza Virus on the Frequency of Acute Otitis Media Is Explained by Lower Adaptive and Innate Immune Responses in Otitis-Prone Children

(2014) David Verhoeven et al.   CLINICAL INFECTIOUS DISEASES

Predicting the impact of new pneumococcal conjugate vaccines: serotype composition is not enough

(2014) William P Hausdorff et al.   Expert Review of Vaccines

Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal Proteins

(2014) Kristin Moffitt et al.   INFECTION AND IMMUNITY

High Nasopharyngeal Pneumococcal Density, Increased by Viral Coinfection, Is Associated With Invasive Pneumococcal Pneumonia

(2014) Nicole Wolter et al.   JOURNAL OF INFECTIOUS DISEASES

Serotype-specific effectiveness and correlates of protection for the 13-valent pneumococcal conjugate vaccine: a postlicensure indirect cohort study

(2014) Nick J Andrews et al.   LANCET INFECTIOUS DISEASES

Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

(2014) Paul V. Licciardi et al.   VACCINE

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Early impact of sequential introduction of 7-valent and 13-valent pneumococcal conjugate vaccine on IPD in Israeli children

(2014) Shalom Ben-Shimol et al.   VACCINE

Pertussis

(2014) Giovanni Gabutti et al.   Human Vaccines & Immunotherapeutics

Serum antibody responses to pneumococcal colonization in the first 2 years of life: results from an SE Asian longitudinal cohort study

(2013) P. Turner et al.   CLINICAL MICROBIOLOGY AND INFECTION

Lower nasopharyngeal epithelial cell repair and diminished innate inflammation responses contribute to the onset of acute otitis media in otitis-prone children

(2013) David Verhoeven et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Population genomics of post-vaccine changes in pneumococcal epidemiology

(2013) Nicholas J Croucher et al.   NATURE GENETICS

Nonprotective Responses to Pediatric Vaccines Occur in Children Who Are Otitis Prone

(2013) Michael E. Pichichero et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Distinct Distal Gut Microbiome Diversity and Composition in Healthy Children from Bangladesh and the United States

(2013) Audrie Lin et al.   PLoS One

Reduced Serum IgG Responses to Pneumococcal Antigens in Otitis-Prone Children May Be Due to Poor Memory B-Cell Generation

(2012) Sharad K. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

Characterization of Th17 responses to Streptococcus pneumoniae in humans: Comparisons between adults and children in a developed and a developing country

(2012) Anna Lundgren et al.   VACCINE

Safety and immunogenicity of pneumococcal protein vaccine candidates: Monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA–pneumococcal histidine triad protein D vaccine

(2012) Monica Bologa et al.   VACCINE

Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine

(2012) Kristin L. Moffitt et al.   VACCINE

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

(2012) Thierry Kamtchoua et al.   VACCINE

Antibody response toStreptococcus pneumoniaeproteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children

(2012) Michael E. Pichichero et al.   Human Vaccines & Immunotherapeutics

Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae

(2012) Yuan Li et al.   PLoS Pathogens

Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants

(2011) Brenda A Kwambana et al.   BMC INFECTIOUS DISEASES

TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization

(2011) Kristin L. Moffitt et al.   Cell Host & Microbe

Reduced Memory CD4+ T-Cell Generation in the Circulation of Young Children May Contribute to the Otitis-Prone Condition

(2011) Sharad K. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children

(2011) Ravinder Kaur et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Protective Contributions against Invasive Streptococcus pneumoniae Pneumonia of Antibody and Th17-Cell Responses to Nasopharyngeal Colonisation

(2011) Jonathan M. Cohen et al.   PLoS One

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization

(2011) Shabir A. Madhi et al.   VACCINE

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

(2010) Ying-Jie Lu et al.   VACCINE

Pneumococcal disease caused by serotype 19A: Review of the literature and implications for future vaccine development

(2010) Rene Reinert et al.   VACCINE

Epidemiological Evidence for Serotype‐Independent Acquired Immunity to Pneumococcal Carriage

(2009) Simo M. Granat et al.   JOURNAL OF INFECTIOUS DISEASES

The pneumococcus: why a commensal misbehaves

(2009) Jeffrey N. Weiser   JOURNAL OF MOLECULAR MEDICINE-JMM

Nasopharyngeal Carriage of Streptococcus pneumoniae in Gambian Infants: A Longitudinal Study

(2008) P. C. Hill et al.   CLINICAL INFECTIOUS DISEASES

Vaccines for the Unvaccinated: Protecting the Herd

(2008) David S. Stephens   JOURNAL OF INFECTIOUS DISEASES

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

(2008) Ying-Jie Lu et al.   PLoS Pathogens