The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

(2016) Xiu-Ming Li et al.   Journal of Inflammation-London

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

(2016) Erik Hedrick et al.   MOLECULAR AND CELLULAR BIOLOGY

Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis

(2015) Takeshi Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

(2015) Sahil Mahajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells

(2015) Daniel Crean et al.   JOURNAL OF IMMUNOLOGY

Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin

(2015) Joseph M McCoy et al.   Journal of Inflammation-London

NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation

(2015) Olivier Calvayrac et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation

(2015) Guijun Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

(2015) Li Li et al.   Nature Chemical Biology

A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro

(2015) Sean L. Hammond et al.   NEUROSCIENCE LETTERS

NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells

(2015) Ricardo Rodríguez-Calvo et al.   THROMBOSIS AND HAEMOSTASIS

The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

(2015) Heba N. Nowyhed et al.   Scientific Reports

Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis

(2015) Pengguo Chen et al.   PeerJ

NR4A nuclear receptors are orphans but not lonesome

(2014) Kondababu Kurakula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model

(2014) Yong Deuk Kim et al.   DIABETES

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

The NR4A orphan nuclear receptors: mediators in metabolism and diseases

(2014) Harmit S. Ranhotra   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

(2014) Syng-Ook Lee et al.   MOLECULAR CANCER RESEARCH

Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells

(2014) Syng-Ook Lee et al.   MOLECULAR ENDOCRINOLOGY

Nur77 Decreases Atherosclerosis Progression in apoE−/− Mice Fed a High-Fat/High-Cholesterol Diet

(2014) Yan-Wei Hu et al.   PLoS One

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

(2014) Briana R. De Miranda et al.   TOXICOLOGICAL SCIENCES

NR4A nuclear receptors in immunity and atherosclerosis

(2013) Anouk A.J. Hamers et al.   CURRENT OPINION IN LIPIDOLOGY

Haloperidol-induced striatalNur77expression in a non-human primate model of tardive dyskinesia

(2013) Souha Mahmoudi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Over-expression of Neuron-derived Orphan Receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury

(2013) R. Rodriguez-Calvo et al.   HUMAN MOLECULAR GENETICS

Perturbation of Transcription FactorNur77Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

(2013) Matthew P. Mount et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NR4A1 enhances neural survival following oxygen and glucose deprivation: An in vitro study

(2013) Guodong Xiao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Minireview: Role Of Orphan Nuclear Receptors in Cancer and Potential as Drug Targets

(2013) Stephen Safe et al.   MOLECULAR ENDOCRINOLOGY

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

(2013) Ben J. E. Raveney et al.   PLoS One

Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription

(2012) Kimberlee S. Mix et al.   ARTHRITIS AND RHEUMATISM

NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors

(2012) Joshua D. Hawk et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory

(2012) S. E. McNulty et al.   LEARNING & MEMORY

NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61

(2012) X. Zhang et al.   PLACENTA

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

(2012) M. S. Fassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of NR4A transcription factors in memory formation

(2011) Josh D. Hawk et al.   BRAIN RESEARCH BULLETIN

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Differential expression of oxidored nitro domain containing protein 1 (NOR1), in mouse tissues and in normal and cancerous human tissues

(2011) Bo Xiang et al.   GENE

NR4A Gene Expression Is Dynamically Regulated in the Ventral Tegmental Area Dopamine Neurons and Is Related to Expression of Dopamine Neurotransmission Genes

(2011) Jeffrey B. Eells et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

(2011) S-O Lee et al.   ONCOGENE

α-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization

(2010) Han-Jong Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar–Kyoto rat model of depression

(2010) Daniel J. Schaffer et al.   BRAIN RESEARCH

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

(2010) Jing-jing Liu et al.   CANCER RESEARCH

Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels

(2010) Peter I. Bonta et al.   CARDIOVASCULAR RESEARCH

Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation

(2010) Peter I. Bonta et al.   CIRCULATION

Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis

(2010) Yue Zhao et al.   CIRCULATION RESEARCH

Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder

(2010) G. Novak et al.   GENES BRAIN AND BEHAVIOR

Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL

(2010) Qin Shao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

(2010) N. Volakakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

(2009) C. Ferlini et al.   CANCER RESEARCH

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Deficiency of the NR4A Neuron-Derived Orphan Receptor-1 Attenuates Neointima Formation After Vascular Injury

(2009) Takashi Nomiyama et al.   CIRCULATION

The Orphan Nuclear Receptor Nur77 Suppresses Endothelial Cell Activation Through Induction of IκBα Expression

(2009) Bei You et al.   CIRCULATION RESEARCH

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

(2009) Lily C. Chao et al.   DIABETES

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

(2009) Ilse M. E. Beck et al.   ENDOCRINE REVIEWS

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis

(2009) Carol M. Aherne et al.   MOLECULAR IMMUNOLOGY

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

(2009) Souha Mahmoudi et al.   NEUROBIOLOGY OF DISEASE

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

(2008) Siva Kumar Kolluri et al.   CANCER CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme

(2008) L. Verstrepen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear Factor- B Induction by Visfatin in Human Vascular Endothelial Cells: Its role in MMP-2/9 production and activation

(2008) R. Adya et al.   DIABETES CARE

Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77

(2008) Yongjuan Zhao et al.   FEBS Journal

Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats

(2008) Radu C. Oita et al.   MECHANISMS OF AGEING AND DEVELOPMENT

1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

(2008) T. Inamoto et al.   MOLECULAR CANCER THERAPEUTICS

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

(2008) Y. Doi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition

(2007) Marina O'Kane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

(2007) Ronald B. Tjalkens et al.   JOURNAL OF NEUROSCIENCE RESEARCH