Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis

(2014) J. M. Coquet et al.   JOURNAL OF IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

(2011) Takashi Sekiya et al.   Nature Communications

Th1 and Th17 cells

(2010) Jesse M. Damsker et al.   Annals of the New York Academy of Sciences

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis

(2009) Christian Klemann et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

(2009) Jyoti Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis

(2009) B. J. E. Raveney et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis

(2009) Carol M. Aherne et al.   MOLECULAR IMMUNOLOGY

Fingolimod (FTY720) as an Acute Rescue Therapy for Intraocular Inflammatory Disease

(2008) B. J. E. Raveney et al.   ARCHIVES OF OPHTHALMOLOGY

IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunityin vivo

(2008) Ivo Sonderegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A rush to judgment on Th17: Figure 1.

(2008) Lawrence Steinman   JOURNAL OF EXPERIMENTAL MEDICINE

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

(2008) Y. Doi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition

(2007) Marina O'Kane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY