Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains

A Novel Approach to Maintain Gut Mucosal Integrity Using an Oral Enzyme Supplement

(2014) Sulaiman R. Hamarneh et al.   ANNALS OF SURGERY

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

(2014) Qin Feng et al.   CELL RESEARCH

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma

(2014) Dhong Hyun Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

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Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression

(2014) Lothar Vassen et al.   PLoS One

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

(2014) Jessica E. Bolden et al.   Cell Reports

Regulation of NO Synthesis, Local Inflammation, and Innate Immunity to Pathogens by BET Family Proteins

(2013) S. Wienerroither et al.   MOLECULAR AND CELLULAR BIOLOGY

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

(2013) S. Picaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia

(2012) Miho Kikuchi et al.   BMC GASTROENTEROLOGY

The intestinal epithelium tuft cells: specification and function

(2012) François Gerbe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dclk1 distinguishes between tumor and normal stem cells in the intestine

(2012) Yuki Nakanishi et al.   NATURE GENETICS

Transcriptional Networks in Liver and Intestinal Development

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Paneth cell α-defensins in enteric innate immunity

(2011) André Joseph Ouellette   CELLULAR AND MOLECULAR LIFE SCIENCES

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(2011) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

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(2011) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs

(2010) Nick Barker et al.   Cell Stem Cell

Investigation of doublecortin and calcium/calmodulin-dependent protein kinase-like-1-expressing cells in the mouse stomach

(2010) Yan Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Release of Endogenous Opioids From Duodenal Enteroendocrine Cells Requires Trpm5

(2009) Zaza Kokrashvili et al.   GASTROENTEROLOGY

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

(2009) Alex Gregorieff et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study

(2008) S. A. Veltkamp et al.   CLINICAL CANCER RESEARCH