AMPA receptors and perampanel behind selected epilepsies: current evidence and future perspectives

Perampanel in 12 patients with Unverricht-Lundborg disease

(2017) Arielle Crespel et al.   EPILEPSIA

A two-year retrospective evaluation of perampanel in patients with highly drug-resistant epilepsy and cognitive impairment

(2017) Bernd Huber et al.   EPILEPSY & BEHAVIOR

Evaluation of perampanel in patients with intellectual disability and epilepsy

(2017) Francesca M. Snoeijen-Schouwenaars et al.   EPILEPSY & BEHAVIOR

Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations

(2017) Charles Vecht et al.   JOURNAL OF NEURO-ONCOLOGY

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Clinical outcomes of perampanel vs. lacosamide in cohorts of consecutive patients with severely refractory epilepsies — A monocentric retrospective analysis of systematically collected data from the German Kork Epilepsy Center

(2017) Christoph Kurth et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Perampanel as add-on treatment in refractory focal epilepsy. The Dianalund experience

(2016) S. Juhl et al.   ACTA NEUROLOGICA SCANDINAVICA

Proceedings of the 2016 Spring Meeting of the Society of British

(2016)   BRITISH JOURNAL OF NEUROSURGERY

Analysis of falls in patients with epilepsy enrolled in the perampanel phase III randomized double-blind studies

(2016) Ilo E. Leppik et al.   EPILEPSIA

Perampanel effects in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and comorbid depressive-like behavior

(2016) Rita Citraro et al.   EPILEPSIA

Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy

(2016) Vera Russmann et al.   EPILEPSIA

Cognitive effects of adjunctive perampanel for partial-onset seizures: A randomized trial

(2016) Kimford J. Meador et al.   EPILEPSIA

Adjunctive perampanel in adolescents with inadequately controlled partial-onset seizures: A randomized study evaluating behavior, efficacy, and safety

(2016) Lieven Lagae et al.   EPILEPSIA

Sleep quality and daytime sleepiness in patients treated with adjunctive perampanel for focal seizures

(2016) Manuel Toledo et al.   EPILEPSY & BEHAVIOR

Safety and efficacy of perampanel in children and adults with various epilepsy syndromes: A single-center postmarketing study

(2016) Kanwaljit Singh et al.   EPILEPSY & BEHAVIOR

Adjunctive perampanel in refractory epilepsy: Experience at tertiary epilepsy care center in Tours

(2016) Aude Maurousset et al.   EPILEPSY & BEHAVIOR

Efficacy and tolerability of perampanel in ten patients with Lafora disease

(2016) Danielle Goldsmith et al.   EPILEPSY & BEHAVIOR

Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: The FYDATA study

(2016) V. Villanueva et al.   EPILEPSY RESEARCH

Pharmacokinetics, exposure–cognition, and exposure–efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures

(2016) Vicente Villanueva et al.   EPILEPSY RESEARCH

Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies—An Italian observational multicenter study

(2016) P. De Liso et al.   EPILEPSY RESEARCH

Efficacy and tolerability of adjunct perampanel based on number of antiepileptic drugs at baseline and baseline predictors of efficacy: A phase III post-hoc analysis

(2016) Tracy Glauser et al.   EPILEPSY RESEARCH

Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas

(2016) Andrew Neal et al.   JOURNAL OF NEURO-ONCOLOGY

Advances in the development of biomarkers for epilepsy

(2016) Asla Pitkänen et al.   LANCET NEUROLOGY

Long-term outcome of mild mesial temporal lobe epilepsy

(2016) Angelo Labate et al.   NEUROLOGY

Inhibition of calcium-permeable and calcium-impermeable AMPA receptors by perampanel in rat brain neurons

(2016) Oleg I. Barygin   NEUROSCIENCE LETTERS

Clinical experience with adjunctive perampanel in adult patients with uncontrolled epilepsy: A UK and Ireland multicentre study

(2016) Emily Shah et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice

(2016) Megumi Akamatsu et al.   Scientific Reports

Two-year real-world experience with perampanel in patients with refractory focal epilepsy: Austrian data

(2016) Alexandra Rohracher et al.   Therapeutic Advances in Neurological Disorders

White matter abnormalities differentiate severe from benign temporal lobe epilepsy

(2015) Angelo Labate et al.   EPILEPSIA

Perampanel efficacy and safety by gender: Subanalysis of phase III randomized clinical studies in subjects with partial seizures

(2015) Blanca Vazquez et al.   EPILEPSIA

Psychiatric and behavioral adverse events in randomized clinical studies of the noncompetitive AMPA receptor antagonist perampanel

(2015) Alan B. Ettinger et al.   EPILEPSIA

Perampanel in patients with refractory and super-refractory status epilepticus in a neurological intensive care unit

(2015) A. Rohracher et al.   EPILEPSY & BEHAVIOR

Efficacy of perampanel in refractory nonconvulsive status epilepticus and simple partial status epilepticus

(2015) Juliane Redecker et al.   EPILEPSY & BEHAVIOR

Lack of effect of perampanel on QT interval duration: Results from a thorough QT analysis and pooled partial seizure Phase III clinical trials

(2015) Haichen Yang et al.   EPILEPSY RESEARCH

Efficacy and safety of perampanel in the subgroup of elderly patients included in the phase III epilepsy clinical trials

(2015) Ilo E. Leppik et al.   EPILEPSY RESEARCH

Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study

(2015) William Rosenfeld et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis

(2015) Caterina Palleria et al.   EXPERT OPINION ON PHARMACOTHERAPY

Perampanel in der Behandlung eines Patienten mit Glioblastoma multiforme ohne IHD-1-Mutation und ohne MGMT-Promotor-Methylierung

(2015) J. Rösche et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Perampanel efficacy and tolerability with enzyme-inducing AEDs in patients with epilepsy

(2015) B. E. Gidal et al.   NEUROLOGY

Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy

(2015) Jacqueline A. French et al.   NEUROLOGY

Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: Results from phase III extension study 307

(2014) Gregory L. Krauss et al.   EPILEPSIA

A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria

(2014) Bernhard J. Steinhoff et al.   EPILEPSY RESEARCH

Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy

(2014) Rita Citraro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Weight of epilepsy in brain tumor patients

(2014) Marta Maschio et al.   JOURNAL OF NEURO-ONCOLOGY

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

(2013) M. A. Rogawski et al.   ACTA NEUROLOGICA SCANDINAVICA

Systematic Review and Meta-Analysis of the Efficacy and Safety of Perampanel in the Treatment of Partial-Onset Epilepsy

(2013) Warrington W. Q. Hsu et al.   CNS DRUGS

Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: A pooled analysis of three phase III studies

(2013) Bernhard J. Steinhoff et al.   EPILEPSIA

Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy

(2013) Mark William Lopes et al.   EXPERIMENTAL BRAIN RESEARCH

Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus

(2012) Karthik Rajasekaran et al.   ANNALS OF NEUROLOGY

Expression of AMPA receptor subunits in hippocampus after status convulsion

(2012) Yue Hu et al.   CHILDS NERVOUS SYSTEM

Perampanel in Parkinson Disease Fluctuations

(2012) Olivier Rascol et al.   CLINICAL NEUROPHARMACOLOGY

Brain Tumor-Related Epilepsy

(2012) Marta Maschio   Current Neuropharmacology

Multireceptor analysis in human neocortex reveals complex alterations of receptor ligand binding in focal epilepsies

(2012) Nicola Palomero-Gallagher et al.   EPILEPSIA

Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

(2012) Jacqueline A. French et al.   EPILEPSIA

Perampanel, a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: Interim results from phase III, extension study 307

(2012) Gregory L. Krauss et al.   EPILEPSIA

New AMPA antagonists in epilepsy

(2012) Emilio Russo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Glutamate Receptor 1 Phosphorylation at Serine 831 and 845 Modulates Seizure Susceptibility and Hippocampal Hyperexcitability after Early Life Seizures

(2012) S. N. Rakhade et al.   JOURNAL OF NEUROSCIENCE

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

(2012) J. A. French et al.   NEUROLOGY

Randomized phase III study 306: Adjunctive perampanel for refractory partial-onset seizures

(2012) G. L. Krauss et al.   NEUROLOGY

Glutamate is associated with a higher risk of seizures in patients with gliomas

(2012) T. I. Yuen et al.   NEUROLOGY

AMPAKINE enhancement of social interaction in the BTBR mouse model of autism

(2012) J.L. Silverman et al.   NEUROPHARMACOLOGY

Overexpression of Calcium-Permeable Glutamate Receptors in Glioblastoma Derived Brain Tumor Initiating Cells

(2012) Michael C. Oh et al.   PLoS One

Tolerability and safety of perampanel: two randomized dose-escalation studies

(2011) G. L. Krauss et al.   ACTA NEUROLOGICA SCANDINAVICA

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Perampanel, an AMPA antagonist, found to have no benefit in reducing “off” time in Parkinson's disease

(2011) Andrew Lees et al.   MOVEMENT DISORDERS

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

GluR1 Phosphorylation and Persistent Expression of Levodopa-induced Motor Response Alterations in the Hemi-Parkinsonian Rat

(2011) Maowen Ba et al.   NEUROCHEMICAL RESEARCH

Therapeutic window of opportunity for the neuroprotective effect of valproate versus the competitive AMPA receptor antagonist NS1209 following status epilepticus in rats

(2011) Melanie Langer et al.   NEUROPHARMACOLOGY

Revisiting AMPA Receptors as an Antiepileptic Drug Target

(2011) Michael A. Rogawski   Epilepsy Currents

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466

(2009) Brita Fritsch et al.   EPILEPSIA

Refractory status epilepticus: A prospective observational study

(2009) Jan Novy et al.   EPILEPSIA

Talampanel With Standard Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma: A Multicenter Phase II Trial

(2009) Stuart A. Grossman et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines

(2009) Hani J. Marcus et al.   JOURNAL OF NEURO-ONCOLOGY

Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate

(2009) Monty A. Silverdale et al.   SYNAPSE

Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures

(2008) S. N. Rakhade et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

AMPA receptors promote perivascular glioma invasion via β1 integrin–dependent adhesion to the extracellular matrix

(2008) Yuji Piao et al.   NEURO-ONCOLOGY