Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases

A potential contribution of antimicrobial peptide LL-37 to tissue fibrosis and vasculopathy in systemic sclerosis

(2016) T. Takahashi et al.   BRITISH JOURNAL OF DERMATOLOGY

Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes

(2016) Andreas Bayer et al.   EXPERIMENTAL DERMATOLOGY

Antimicrobial peptides and wound healing: biological and therapeutic considerations

(2016) Maria Luisa Mangoni et al.   EXPERIMENTAL DERMATOLOGY

Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

(2016) Laura Giusti et al.   Journal of Translational Medicine

Antimicrobial efficacy of granulysin-derived synthetic peptides in acne vulgaris

(2015) Hee-Sun Lim et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes

(2015) Rithee Smithrithee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to Pruritus

(2015) Yoshie Umehara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

The antimicrobial protein S100A7/psoriasin enhances the expression of keratinocyte differentiation markers and strengthens the skin's tight junction barrier

(2014) F. Hattori et al.   BRITISH JOURNAL OF DERMATOLOGY

Targeted silencing of DEFB4 in a bioengineered skin-humanized mouse model for psoriasis: development of siRNA SECosome-based novel therapies

(2014) Stefanie Bracke et al.   EXPERIMENTAL DERMATOLOGY

Endoplasmic reticulum stress: key promoter of rosacea pathogenesis

(2014) Bodo C. Melnik   EXPERIMENTAL DERMATOLOGY

The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function

(2014) Toshihiro Akiyama et al.   Journal of Innate Immunity

Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes

(2014) Chanisa Kiatsurayanon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial

(2014) Alvar Grönberg et al.   WOUND REPAIR AND REGENERATION

The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis

(2014) A. Batycka-Baran et al.   Journal of Immunology Research

Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes

(2013) Xue Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antimicrobial peptides and pro-inflammatory cytokines are differentially regulated across epidermal layers following bacterial stimuli

(2013) Giuseppe Percoco et al.   EXPERIMENTAL DERMATOLOGY

What is the role of antimicrobial peptides (AMP) in acne vulgaris?

(2013) Jürgen Harder et al.   EXPERIMENTAL DERMATOLOGY

Differential expression andin vivosecretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin

(2013) Maike Wittersheim et al.   EXPERIMENTAL DERMATOLOGY

 -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-  Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

(2013) P. Tewary et al.   JOURNAL OF IMMUNOLOGY

 -Defensins Activate Human Mast Cells via Mas-Related Gene X2

(2013) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Epidemiology of atopic dermatitis: a review

(2012) Sigrid Payne DaVeiga   ALLERGY AND ASTHMA PROCEEDINGS

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease

(2012) Markus Reinholz et al.   Annals of Dermatology

S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin

(2012) Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The skin surface as antimicrobial barrier: present concepts and future outlooks

(2012) Jürgen Harder et al.   EXPERIMENTAL DERMATOLOGY

Novel insights into the role of S100A8/A9 in skin biology

(2012) Claus Kerkhoff et al.   EXPERIMENTAL DERMATOLOGY

Beyond conventional antibiotics for the future treatment of methicillin-resistantStaphylococcus aureusinfections: two novel alternatives

(2012) Deirdre Fitzgerald-Hughes et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

(2012) Brendan M. Giles et al.   IMMUNOLOGIC RESEARCH

Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB

(2012) Toan The Nguyen et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Antimicrobial RNases in Cutaneous Defense

(2012) Maren Simanski et al.   Journal of Innate Immunity

Association of β-Defensin Copy Number and Psoriasis in Three Cohorts of European Origin

(2012) Philip E. Stuart et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

(2012) H.C. Korting et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

(2011) Emman Shubbar et al.   BREAST CANCER RESEARCH AND TREATMENT

The effect of pimecrolimus on expression of genes associated with skin barrier dysfunction in atopic dermatitis skin lesions

(2011) Alicja Grzanka et al.   EXPERIMENTAL DERMATOLOGY

Increased serum human β-defensin-2 levels in atopic dermatitis: Relationship to IL-22 and oncostatin M

(2011) Naoko Kanda et al.   IMMUNOBIOLOGY

Mas-related Gene X2 (MrgX2) Is a Novel G Protein-coupled Receptor for the Antimicrobial Peptide LL-37 in Human Mast Cells

(2011) Hariharan Subramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermal Proteases in the Pathogenesis of Rosacea

(2011) Ulf Meyer-Hoffert et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Neurovascular and Neuroimmune Aspects in the Pathophysiology of Rosacea

(2011) Verena D. Schwab et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus

(2011) Alexander Kreuter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

History of eczema herpeticum is associated with the inability to induce human β-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis

(2010) T.R. Hata et al.   BRITISH JOURNAL OF DERMATOLOGY

The eight human “canonical” ribonucleases: Molecular diversity, catalytic properties, and special biological actions of the enzyme proteins

(2010) Salvatore Sorrentino   FEBS LETTERS

UV-B–triggered induction of vitamin D3 metabolism differentially affects antimicrobial peptide expression in keratinocytes

(2010) Mark Peric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

EGFR (Trans)activation Mediates IL-8 and Distinct Human Antimicrobial Peptide and Protein Production following Skin Injury

(2010) Amanda S. Büchau   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial Skin Injury

(2010) Jürgen Harder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes

(2010) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Elevated levels of human beta-defensin 2 and human neutrophil peptides in systemic lupus erythematosus

(2010) S. Vordenbäumen et al.   LUPUS

Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation

(2010) R. Wolf et al.   Science Translational Medicine

Alteration of Tight Junction Proteins Is an Early Event in Psoriasis

(2009) Nina Kirschner et al.   AMERICAN JOURNAL OF PATHOLOGY

Lack of Evidence for Bacterial Infections in Skin in Patients With Systemic Sclerosis

(2009) Maureen D. Mayes et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7

(2009) K. Reithmayer et al.   BRITISH JOURNAL OF DERMATOLOGY

Multifunctional Antimicrobial Proteins and Peptides: Natural Activators of Immune Systems

(2009) Francois Niyonsaba et al.   CURRENT PHARMACEUTICAL DESIGN

Copy number variation of beta-defensins and relevance to disease

(2009) E.J. Hollox   CYTOGENETIC AND GENOME RESEARCH

UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo

(2009) Regine Gläser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human beta-defensin-3 promotes wound healing in infected diabetic wounds

(2009) Tobias Hirsch et al.   JOURNAL OF GENE MEDICINE

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microanalysis of an antimicrobial peptide, β-defensin-2, in the stratum corneum from patients with atopic dermatitis

(2008) S. Asano et al.   BRITISH JOURNAL OF DERMATOLOGY

The human antimicrobial peptide dermcidin activates normal human keratinocytes

(2008) F. Niyonsaba et al.   BRITISH JOURNAL OF DERMATOLOGY

The vitamin D pathway: a new target for control of the skins immune response?

(2008) Jrgen Schauber et al.   EXPERIMENTAL DERMATOLOGY

Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

(2008) Arby Abtin et al.   FASEB JOURNAL

Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation

(2008) Yan Zheng et al.   IMMUNOLOGY

Differential mRNA Expression of Antimicrobial Peptides and Proteins in Atopic Dermatitis as Compared to Psoriasis Vulgaris and Healthy Skin

(2008) Thilo Gambichler et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Evaluation of the effect of human  -defensins on neutrophil apoptosis

(2008) I. Nagaoka et al.   INTERNATIONAL IMMUNOLOGY

Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes

(2008) François Niyonsaba et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37

(2008) Hyun Jeong Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Antimicrobial Protein Psoriasin (S100A7) Is Upregulated in Atopic Dermatitis and after Experimental Skin Barrier Disruption

(2008) Regine Gläser et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RNase A ribonucleases and host defense: an evolving story

(2008) Helene F. Rosenberg   JOURNAL OF LEUKOCYTE BIOLOGY

Antimicrobial human beta-defensin-2 stimulates migration, proliferation and tube formation of human umbilical vein endothelial cells

(2008) Adone Baroni et al.   PEPTIDES

Developments in the scientific understanding of lupus

(2008) Stacy P Ardoin et al.   ARTHRITIS RESEARCH & THERAPY

Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers

(2007) Karin M. Aberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY