期刊
EXPERIMENTAL DERMATOLOGY
卷 26, 期 11, 页码 989-998出版社
WILEY
DOI: 10.1111/exd.13314
关键词
antimicrobial agent; infection; inflammation; skin immunity; therapeutic agent
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [26461703]
- Atopy (Allergy) Research Center, Juntendo University, Tokyo, Japan
- Japan International Cooperation Agency (JICA)
- Grants-in-Aid for Scientific Research [17K10254, 26461703] Funding Source: KAKEN
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Despite the fact that AMPs/HDPs protect our body, several studies have hypothesized that these molecules actively contribute to the pathogenesis of various skin diseases. For example, AMPs/HDPs play crucial roles in the pathological processes of psoriasis, atopic dermatitis, rosacea, acne vulgaris, systemic lupus erythematosus and systemic sclerosis. Thus, AMPs/HDPs may be a double-edged sword, promoting cutaneous immunity while simultaneously initiating the pathogenesis of some skin disorders. This review will describe the most common skin-derived AMPs/HDPs (defensins, cathelicidins, S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the positive and negative aspects of these AMPs/HDPs in skin inflammatory/infectious diseases. Understanding the regulation, functions and mechanisms of AMPs/HDPs may offer new therapeutic opportunities in the treatment of various skin disorders.
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