Article
Allergy
Michelle F. Huffaker, Kanika Kanchan, Henry T. Bahnson, Ingo Ruczinski, Gautam Shankar, Donald Y. M. Leung, Carolyn Baloh, George Du Toit, Gideon Lack, Gerald T. Nepom, Rasika A. Mathias
Summary: This study found that deleterious variation in the epidermal differentiation complex (EDC) is associated with the severity of atopic dermatitis (AD) and the risk of peanut allergy (PA). Specifically, variations in the FLG gene are significantly associated with AD severity and the risk of PA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Thomas Luger, Uladzimir Adaskevich, Maryna Anfilova, Xia Dou, Nikolay N. Murashkin, Leyla Namazova-Baranova, Oleg Nitochko, Ashraf Reda, Tetyana V. Svyatenko, Zeynep Tamay, Mohammad Tawara, Elena A. Vishneva, Svitlana Vozianova, Hua Wang, Zuotao Zhao
Summary: A treatment algorithm for atopic dermatitis patients, focusing on topical therapies, was proposed in the article. It provides recommendations for different body locations and severity of symptoms. This algorithm can guide clinical decision-making in the treatment of atopic dermatitis.
JOURNAL OF DERMATOLOGY
(2021)
Review
Allergy
Thomas Luger, Matthias Augustin, Julien Lambert, Carle Paul, Carlo Pincelli, Antonio Torrelo, Christian Vestergaard, Ulrich Wahn, Thomas Werfel
Summary: Atopic dermatitis (AD) is a common skin disease in infants that requires effective treatment options for symptom relief. Topical calcineurin inhibitors (TCIs) have been recommended for long-term use in infants with AD, with pimecrolimus proving to be a safe and effective alternative to topical corticosteroids (TCS). Safety concerns regarding pimecrolimus use in infants aged 3 months and above are no longer valid based on available evidence.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Nao Tanaka, Masaru Koido, Akari Suzuki, Nao Otomo, Hiroyuki Suetsugu, Yuta Kochi, Kouhei Tomizuka, Yukihide Momozawa, Yoichiro Kamatani, Shiro Ikegawa, Kazuhiko Yamamoto, Chikashi Terao
Summary: This study identified multiple significant susceptibility loci for AD, including both Japanese-specific loci and novel loci shared across different populations. Downstream analyses revealed substantial overlap of GWAS signals in enhancers of skin cells and immune cells, particularly CD4 T cells.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sarita Kanwal, Shanker K. Singh, Sandeep P. Soman, Soumen Choudhury, Priyambada Kumari, Pradeep K. Ram, Satish K. Garg
Summary: In this study, it was found that dogs with AD have significantly higher expression of FLG gene and significantly lower expression of IVL gene in the skin, in addition to significantly increased expression of TNF-alpha, IL-31, and IL-13 genes in their peripheral blood mononuclear cells. These findings suggest that the disruption of skin barrier in dogs with AD may be attributed to the altered expression of FLG and IVL genes, while the clinical manifestations of AD may be associated with the overexpression of TNF-alpha, IL-31, and IL-13 genes. Further studies are needed to confirm these findings and explore the pathogenesis of AD in dogs.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Regina Foelster-Holst, Rahel Reimer, Claudia Neumann, Erhardt Proksch, Elke Rodriguez, Stephan Weidinger, Mohamad Goldust, Eckhard Hanisch, Stephan Daehnhardt-Pfeiffer, Sandra Freitag-Wolf
Summary: Atopic dermatitis and prurigo nodularis are two chronic skin diseases characterized by impaired skin barrier and disturbed water balance. Basic barrier repair is crucial for the treatment of both conditions.
Article
Dermatology
Efstratios Vakirlis, Aikaterini Tsentemeidou, Stamatios Gregoriou
Summary: The study suggests that the use of topical calcineurin inhibitors may increase the risk of lymphoma in patients with atopic dermatitis, but caution is needed when interpreting potential risks.
DERMATOLOGY AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsoe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Summary: This study used BRB-seq technique to analyze the transcriptome of tape-stripped skin samples from atopic dermatitis patients and healthy controls. An AD signature consisting of genes related to skin barrier and inflammatory response was identified. However, the low and highly variable transcript counts in tape-stripped samples were a limiting factor for epidermal transcriptome profiling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alicja Majewska, Malgorzata Gajewska, Kourou Dembele
Summary: Canine atopic dermatitis (cAD) is a chronic and recurrent inflammatory skin disorder. Allergen-specific immunotherapy (ASIT) is recognized as an effective treatment for allergies. This study analyzed changes in gene expression in cAD patients after undergoing ASIT. Nine differentially expressed genes related to the dysregulated immune response in cAD patients were identified, and the expressions of five of these genes changed after ASIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhao-Yuan Wang, Yu-Xin Zheng, Fan Xu, Ying-Zhe Cui, Xue-Yan Chen, Si-Qi Chen, Bing-Xi Yan, Yuan Zhou, Min Zheng, Xiao-Yong Man
Summary: In this study, it was found that epidermal keratinocyte-specific STAT3 deficiency may aggravate AD-like skin inflammation in mice, possibly through TSLP dysregulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Nikolay N. Murashkin, Leyla S. Namazova-Baranova, Svetlana G. Makarova, Roman A. Ivanov, Stepan G. Grigorev, Dmitri V. Fedorov, Eduard T. Ambarchian, Roman V. Epishev, Alexander I. Materikin, Leonid A. Opryatin, Alena A. Savelova
Summary: The use of pimecrolimus for early intervention treatment can effectively reduce transcutaneous sensitization to allergens and decrease allergic reactions in infants with atopic dermatitis.
FRONTIERS IN PEDIATRICS
(2023)
Review
Dermatology
Chia-Yu Chu, Tsung-Chieh Yao, I. -Hsin Shih, Chin-Yi Yang, Chan Lee Chin, Sabeera Begum Binti Kader Ibrahim, Suganthi Thevarajah, Leong Kin Fon, Marco Hok-Kung Ho, Chow Chung Mo, Chow Pok Yu, Steven King-Fan Loo, Thomas Luger
Summary: Atopic dermatitis (AD) has seen an increase in incidence among pediatric patients in the Asia-Pacific region. Factors such as genetics, environment, and culture contribute to differences in clinical presentation and prevalence of AD among races. Early treatment, using topical corticosteroids (TCS) as first-line therapy, is important to prevent the development of comorbidities. Pimecrolimus, a topical calcineurin inhibitor (TCI) with less adverse effects than TCS, has been shown to be safe and effective in treating mild to moderate AD, but its use in infants is still restricted in some Asian countries.
DERMATOLOGY AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Hiroyuki Iida, Ari Pekka Maehoenen, Gerd Juergens, Shinobu Takada
Summary: The fate of plant cells is determined by their relative positions during development. In Arabidopsis thaliana, when inner leaf mesophyll cells are exposed to the surface, they up-regulate ATML1 protein expression, which controls epidermal cell identity. Mechanically signaling, such as pressure release, plays a crucial role in restricting ATML1 activity to outermost cells and facilitating epidermal differentiation.
NATURE COMMUNICATIONS
(2023)
Article
Allergy
Lena Moebus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Huebenthal, Dora Stoelzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Summary: This study explored the blood transcriptomic features of moderate to severe atopic dermatitis (AD). The results showed that AD patients exhibited pronounced inflammatory expression signatures and could be stratified into eosinophilic and noneosinophilic endotypes. Additionally, treatment strategies for the eosinophil-high endotype may require more attention to the restoration of natural killer cell function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Cristoforo Incorvaia, Mona Al-Ahmad, Ignacio J. Ansotegui, Stefania Arasi, Claus Bachert, Catherine Bos, Jean Bousquet, Andrzej Bozek, Davide Caimmi, Moises A. Calderon, Thomas Casale, Adnan Custovic, Frederic De Blay, Pascal Demoly, Philippe Devillier, Alain Didier, Alessandro Fiocchi, Adam T. Fox, Philippe Gevaert, Maximiliano Gomez, Enrico Heffler, Natalia Ilina, Carla Irani, Marek Jutel, Efstrathios Karagiannis, Ludger Klimek, Piotr Kuna, Robin O'Hehir, Oxana Kurbacheva, Paolo M. Matricardi, Mario Morais-Almeida, Ralph Mosges, Natalija Novak, Yoshitaka Okamoto, Petr Panzner, Nikolaos G. Papadopoulos, Hae-Sim Park, Giovanni Passalacqua, Ruby Pawankar, Oliver Pfaar, Peter Schmid-Grendelmeier, Silvia Scurati, Miguel Tortajada-Girbes, Carmen Vidal, J. Christian Virchow, Ulrich Wahn, Margitta Worm, Petra Zieglmayer, Giorgio W. Canonica
Summary: The introduction of personalized medicine has revolutionized the approach to treating diseases by focusing on treating the individual patient. Personalized medicine has shown significant improvements in allergy diagnosis by identifying specific allergens and predicting patient responsiveness to therapies, thereby enhancing the effectiveness of allergen immunotherapy.
Article
Allergy
Gunter Johannes Sturm, Sereina Annik Herzog, Werner Aberer, Teresa Alfaya Arias, Dario Antolin-Amerigo, Patrizia Bonadonna, Elisa Boni, Andrzej Bozek, Marta Chelminska, Barbara Ernst, Nina Frelih, Radoslaw Gawlik, Asli Gelincik, Thomas Hawranek, Wolfram Hoetzenecker, Aranzazu Jimenez Blanco, Karolina Kita, Resat Kendirlinan, Mitja Kosnik, Karin Laipold, Roland Lang, Francesco Marchi, Marina Mauro, Marita Nittner-Marszalska, Iwona Poziomkowska-Gesicka, Valerio Pravettoni, Donatella Preziosi, Oliviero Quercia, Norbert Reider, Marta Rosiek-Biegus, Berta Ruiz-Leon, Christoph Schrautzer, Pilar Serrano, Aytul Sin, Betul Ayse Sin, Johanna Stoevesandt, Axel Trautmann, Martina Vachova, Lisa Arzt-Gradwohl
Summary: The study found that taking beta-blockers or ACE inhibitors does not increase the frequency of systemic adverse events during venom immunotherapy, nor aggravate systemic insect sting reactions. Additionally, these drugs do not impair the effectiveness of venom immunotherapy.
Article
Biotechnology & Applied Microbiology
Andrzej Bozek, Renata Kozlowska, Beata Galuszka, Alicja Grzanka
Summary: The observational study found that after influenza vaccination, middle-aged individuals had a significantly lower risk of SARS-CoV-2 infection, indicating that the vaccine may partially reduce the risk of infection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Infectious Diseases
Magdalena Krupka, Andrzej Bozek, Dorota Bartusik-Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: The study demonstrated the efficacy of photodynamic therapy for infected chronic leg ulcers, with 40% of patients achieving complete remission, 40% experiencing partial response, and 20% showing no response. It also suggested that PDT can be used as a minimally invasive and effective method for treating leg ulcers.
Article
Allergy
Andrzej Bozek, Beata Galuszka, Radoslaw Gawlik, Maciej Misiolek, Wojciech Scierski, Alicja Grzanka, Giorgio Walter Canonica
Summary: For adult patients with local allergic rhinitis and asthma, a 12-month course of sublingual immunotherapy for house dust mite allergies can improve nasal and bronchial symptoms and reduce symptomatic treatment.
Article
Allergy
Andrzej Bozek, Jolanta Zalejska Fiolka, Zenon Czuba, Martyna Miodonska, Renata Kozlowska
Summary: This study compared the cytokine profile in patients with allergic asthma and analyzed the impact of Der p 23 allergy. The results showed that patients with Der p 23 allergy had higher levels of Il-1 and Il-5 activity, which could contribute to more effective allergic inflammation.
Article
Allergy
Magdalena Krupka-Olek, Andrzej Bozek, Milena Drewienkowska, Krzysztof Dryjka, Agata Medrala
Summary: This study analyzed a group of adult patients with concomitant psoriasis and atopic dermatitis, and compared their cytokine profiles with those of homogeneous psoriasis or atopic dermatitis patients and healthy controls. The results suggest that the role of T helper 17 cells may be more essential than previously thought.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Biotechnology & Applied Microbiology
Andrzej Bozek, Renata Kozlowska, Maciej Misiolek, Wojciech Scierski, Radoslaw Gawlik
Summary: This study investigated the combined therapy of omalizumab and sublingual immunotherapy in patients with house dust mite allergy and local allergic rhinitis (LAR). The results showed significant improvements in symptom scores and medication usage compared to therapy with omalizumab alone or sublingual immunotherapy alone.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Marita Nittner-Marszalska, Agnieszka Kopec, Aleksandra Foks-Ciekalska, Aleksandra Lata, Agnieszka Bogacz- Piaseczynska, Marta Rosiek-Biegus, Magdalena Zajac, Andrzej Bozek
Summary: This study aimed to investigate whether immunotherapy with HDM extracts leads to new sensitizations and found that no new sensitizations were observed in patients receiving immunotherapy, while new sensitizations to one HDM molecule were observed in patients who did not receive immunotherapy. Additionally, the study found that sIgE levels against HDM extracts decreased in some patients after 12 months of immunotherapy.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Allergy
Andrzej Bozek
Summary: This review presents current knowledge on the effectiveness and safety of allergen immunotherapy (AIT) in patients over 60 years old with inhalant allergies. Studies have shown the effectiveness of AIT in treating allergic rhinitis in seniors, with evidence from trials using sublingual and injection immunotherapy. Data confirm the high safety of AIT in this age group. Seniors with allergic rhinitis or asthma may benefit from AIT if there are no contraindications, and sustained clinical benefit can be experienced even after completing treatment.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Aleksandra Foks-Ciekalska, Jerzy Jarzab, Ewa Hadas, Elzbieta Swietochowska, Kamila Gumieniak, Wiktor Ciekalski, Andrzej Bozek
Summary: This study aimed to assess the usefulness of potential stress biomarkers in saliva for monitoring the treatment of psoriasis. The results showed that saliva concentrations of sIgA, sAA, and CgA can serve as potential markers for measuring the severity of psoriasis and the associated stress reaction.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Magdalena Zajac, Andrzej Bozek, Renata Kozlowska, Alicja Grzanka
Summary: This study aimed to assess the incidence of a subtype of angioedema-C1-INH-AAE (acquired angioedema with C1 inhibitor deficiency). The study found that C1-INH-AAE occurred more often in patients with cancer, especially in the early stages of breast cancer.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Agnieszka Bogacz-Piaseczynska, Andrzej Bozek
Summary: This study investigated the efficacy and safety of allergen immunotherapy (AIT) in adult patients with atopic dermatitis (AD) and monosensitisation to house dust mites (HDMs). The results showed significant improvement in skin symptoms of AD patients after 12 months of AIT treatment, with decreased EASI scores, % BSA, and IsGA index compared to the placebo group. Therefore, HDM-AIT is effective in improving atopic dermatitis in patients with confirmed monovalent mite allergy.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Magdalena Krupka-Olek, Andrzej Bozek, Aleksandra Kawczyk-Krupka
Summary: Inhalation-dependent IgE sensitizations were common in patients with atopic dermatitis (AD) and possible in patients with psoriasis (PS), often without clinical manifestations in the latter. The investigated cytokine profiles showed high convergence in both AD and PS patients, confirming the active inflammatory nature of these diseases.
MEDICINA-LITHUANIA
(2022)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)