Platinum Intercalators of DNA as Anticancer Agents

Multifaceted Studies of the DNA Interactions and In Vitro Cytotoxicity of Anticancer Polyaromatic Platinum(II) Complexes

(2016) Benjamin J. Pages et al.   CHEMISTRY-A EUROPEAN JOURNAL

Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents

(2016) S. Ding et al.   DALTON TRANSACTIONS

A comparison of the toxicity and tolerability of two intraperitoneal chemotherapy regimens for advanced-stage epithelial ovarian cancer

(2016) Geneviève Bouchard-Fortier et al.   GYNECOLOGIC ONCOLOGY

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

(2016) K. Benjamin Garbutcheon-Singh et al.   INORGANICA CHIMICA ACTA

Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent

(2016) Cale D. Fahrenholtz et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands

(2016) Benjamin J. Pages et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma

(2016) Keiko Hosohata et al.   TOXICOLOGY

Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

(2016) Sin Ki Fung et al.   Nature Communications

Improved DNA equilibrium binding affinity determinations of platinum(ii) complexes using synchrotron radiation circular dichroism

(2015) Dale L. Ang et al.   ANALYST

Cellular Recognition and Repair of Monofunctional–Intercalative Platinum–DNA Adducts

(2015) Fang Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and Analysis of the Structure, Diffusion and Cytotoxicity of Heterocyclic Platinum(IV) Complexes

(2015) Freddy J. Macias et al.   CHEMISTRY-A EUROPEAN JOURNAL

The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(ii) complexes

(2015) Benjamin W. J. Harper et al.   DALTON TRANSACTIONS

Cytotoxicity and Structural Analyses of 2,2′-Bipyridine-, 4,4′-Dimethyl-2,2′-bipyr­idine- and 2-(2′-Pyridyl)quinoxalineplatinum(II) Complexes

(2015) Benjamin J. Pages et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions

(2015) Johnson Lui-Lui Tsai et al.   Chemical Science

Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double-Stranded DNA and RNA: Differential Emissions and Anticancer Activities

(2014) Taotao Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Induced Annihilation of Tumor Cells with Platinum-Porphyrin Conjugates

(2014) Anu Naik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Enzymatically Cleavable Prodrugs of a Potent Platinum-Containing Anticancer Agent

(2014) Song Ding et al.   CHEMISTRY-A EUROPEAN JOURNAL

Redesigning the DNA-Targeted Chromophore in Platinum-Acridine Anticancer Agents: A Structure-Activity Relationship Study

(2014) Amanda J. Pickard et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and analysis of the anticancer activity of platinum(ii) complexes incorporating dipyridoquinoxaline variants

(2014) Benjamin J. Pages et al.   DALTON TRANSACTIONS

A dual-targeting, p53-independent, apoptosis-inducing platinum(ii) anticancer complex, [Pt(BDIQQ)]Cl

(2014) Kogularamanan Suntharalingam et al.   Metallomics

PT-ACRAMTU, A Platinum–Acridine Anticancer Agent, Lengthens and Aggregates, but does not Stiffen or Soften DNA

(2013) Samrat Dutta et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The effects of 56MESS on mitochondrial and cytoskeletal proteins and the cell cycle in MDCK cells

(2013) K. Benjamin Garbutcheon-Singh et al.   Metallomics

Combination studies of platinum(ii)-based metallointercalators with buthionine-S,R-sulfoximine, 3-bromopyruvate, cisplatin or carboplatin

(2013) K. Benjamin Garbutcheon-Singh et al.   Metallomics

DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers

(2012) Jimmy Suryadi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?

(2012) Kimberley J. Davis et al.   DALTON TRANSACTIONS

Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand

(2012) Jennifer M. Hope et al.   DALTON TRANSACTIONS

Cytotoxic platinum(ii) intercalators that incorporate 1R,2R-diaminocyclopentane

(2012) K. Benjamin Garbutcheon-Singh et al.   DALTON TRANSACTIONS

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells

(2012) Xin Qiao et al.   Metallomics

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

(2012) Ajay Ummat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Entropy Balance in the Intercalation Process of an Anti-Cancer Drug Daunomycin

(2011) Arnab Mukherjee   Journal of Physical Chemistry Letters

Unusual Reactivity of a Potent Platinum–Acridine Hybrid Antitumor Agent

(2011) Leigh A. Graham et al.   ACS Medicinal Chemistry Letters

Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Nonsmall Cell Lung Cancer

(2011) Christopher L. Smyre et al.   ACS Medicinal Chemistry Letters

Discrepancy between in vitro and in vivo antitumor effect of a new platinum(II) metallointercalator

(2010) Johnny Moretto et al.   INVESTIGATIONAL NEW DRUGS

Calculation of the electrostatic charges and energies for intercalation of aromatic drug molecules with DNA

(2009) V. V. Kostjukov et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells

(2009) Anwen M. Krause-Heuer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replacement of a Thiourea-S with an Amidine-NH Donor Group in a Platinum−Acridine Antitumor Compound Reduces the Metal’s Reactivity with Cysteine Sulfur

(2009) Zhidong Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo studies of a platinum(ii) metallointercalator

(2008) Dianne M. Fisher et al.   CHEMICAL COMMUNICATIONS

A comparison of the binding of metal complexes to duplex and quadruplex DNA

(2008) Jihan Talib et al.   DALTON TRANSACTIONS

Substituted β-Cyclodextrin and Calix[4]arene As Encapsulatory Vehicles for Platinum(II)-Based DNA Intercalators

(2008) Anwen M. Krause-Heuer et al.   INORGANIC CHEMISTRY

Degradation of Bidentate-Coordinated Platinum(II)-Based DNA Intercalators by Reducedl-Glutathione

(2008) Sharon Kemp et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Non-Cross-Linking Platinum−Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer

(2008) Zhidong Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY