MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

(2017) Malliga R. Iyer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity

(2016) A M Monteleone et al.   EUROPEAN JOURNAL OF NUTRITION

The CB1Neutral Antagonist AM4113 Retains the Therapeutic Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and Weight Loss with Better Psychiatric Tolerability

(2016) Aliou B. Gueye et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

(2016) F. Rossi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

A cannabinoid link between mitochondria and memory

(2016) Etienne Hebert-Chatelain et al.   NATURE

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease

(2016) Shira Zelber-Sagi et al.   Obesity

Consumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTA

(2016) Shuai Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools

(2016) Giorgia Macedonio et al.   PROTEIN AND PEPTIDE LETTERS

Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans

(2016) Jonathan Cedernaes et al.   PSYCHONEUROENDOCRINOLOGY

Disturbances of sleep and circadian rhythms

(2016) Josiane L. Broussard et al.   Current Opinion in Endocrinology Diabetes and Obesity

α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility

(2016) Alexandre Fisette et al.   Cell Reports

Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

(2016) Juan Mendizabal-Zubiaga et al.   Frontiers in Physiology

Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

(2016) Ibrahim Knani et al.   Molecular Metabolism

Cannabinoid modulation of drug reward and the implications of marijuana legalization

(2015) Dan P. Covey et al.   BRAIN RESEARCH

The cannabinoid CB1receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice

(2015) Francisco J. Bermudez-Silva et al.   Disease Models & Mechanisms

Cannabinoid Type 1 (CB1) Receptors on Sim1-Expressing Neurons Regulate Energy Expenditure in Male Mice

(2015) Pierre Cardinal et al.   ENDOCRINOLOGY

Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans

(2015) Ilario Mennella et al.   JOURNAL OF NUTRITION

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture

(2015) Katarzyna Malenczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture

(2015) Cyro José de Moraes Martins et al.   PLoS One

Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa

(2014) Alessio Maria Monteleone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Endocannabinoids, Related Compounds and Their Metabolic Routes

(2014) Filomena Fezza et al.   MOLECULES

The endocannabinoid system controls food intake via olfactory processes

(2014) Edgar Soria-Gómez et al.   NATURE NEUROSCIENCE

A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome

(2014) Nicole P. Bowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pregnenolone Can Protect the Brain from Cannabis Intoxication

(2014) Monique Vallée et al.   SCIENCE

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

(2014) Pierre Cardinal et al.   Molecular Metabolism

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats

(2013) Nicholas V. DiPatrizio et al.   FASEB JOURNAL

Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

(2013) Natsuo Ueda et al.   FEBS Journal

Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides

(2013) Resat Cinar et al.   HEPATOLOGY

CB1Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release

(2013) Katarzyna Malenczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men

(2013) Kjetil Berge et al.   Lipids in Health and Disease

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Central functional response to the novel peptide cannabinoid, hemopressin

(2013) Garron T. Dodd et al.   NEUROPHARMACOLOGY

Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study

(2013) Joseph Abdulnour et al.   Obesity

Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade

(2013) L. Bellocchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fatty gut feeling

(2013) Daniele Piomelli   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes

(2013) Barbara Bosier et al.   Molecular Metabolism

Sheep cheese naturally enriched in α-linolenic, conjugated linoleic and vaccenic acids improves the lipid profile and reduces anandamide in the plasma of hypercholesterolaemic subjects

(2012) Stefano Pintus et al.   BRITISH JOURNAL OF NUTRITION

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism

(2012) Kwang-Mook Jung et al.   Cell Metabolism

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders

(2012) Cristoforo Silvestri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

(2012) Jie Liu et al.   GASTROENTEROLOGY

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1Receptors

(2012) Mark Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedonic Eating Is Associated with Increased Peripheral Levels of Ghrelin and the Endocannabinoid 2-Arachidonoyl-Glycerol in Healthy Humans: A Pilot Study

(2012) Palmiero Monteleone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating anandamide and blood pressure in patients with obstructive sleep apnea

(2012) Stefan Engeli et al.   JOURNAL OF HYPERTENSION

Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice

(2012) S. Y. Romero-Zerbo et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neutral antagonism at the cannabinoid 1 receptor: a safer treatment for obesity

(2012) F J Meye et al.   MOLECULAR PSYCHIATRY

Mitochondrial CB1 receptors regulate neuronal energy metabolism

(2012) Giovanni Bénard et al.   NATURE NEUROSCIENCE

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity

(2012) Isabelle Matias et al.   PLoS One

Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity

(2011) A. Quercioli et al.   EUROPEAN HEART JOURNAL

Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity

(2011) B Gatta-Cherifi et al.   INTERNATIONAL JOURNAL OF OBESITY

Endocannabinoid signal in the gut controls dietary fat intake

(2011) N. V. DiPatrizio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

(2010) NL Cluny et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB1 Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance

(2010) Carmelo Quarta et al.   Cell Metabolism

Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs

(2010) V. Marzo et al.   CURRENT MEDICINAL CHEMISTRY

Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways

(2010) L. Tedesco et al.   DIABETES

Effects of in vitro antagonism of endocannabinoid-1 receptors on the glucose transport system in normal and insulin-resistant rat skeletal muscle

(2010) K. A. Lindborg et al.   DIABETES OBESITY & METABOLISM

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age

(2010) J. Agudo et al.   DIABETOLOGIA

Psychiatric adverse effects of rimonobant in adults with Prader Willi syndrome

(2010) Roja Motaghedi et al.   European Journal of Medical Genetics

Circulating Endocannabinoids and N-acyl-ethanolamides in Patients with Sleep Apnea – Specific Role of Oleoylethanolamide

(2010) R. Jumpertz et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ

(2010) Bani Mukhopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gender, Age, Body Mass Index, and IGF-I Individually and Jointly Determine Distinct GH Dynamics: Analyses in One Hundred Healthy Adults

(2010) Johannes D. Veldhuis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

The Peptide Hemopressin Acts through CB1 Cannabinoid Receptors to Reduce Food Intake in Rats and Mice

(2010) G. T. Dodd et al.   JOURNAL OF NEUROSCIENCE

Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial

(2010) Eric J Topol et al.   LANCET

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?

(2010) F.J. Bermudez-Silva et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Biomarkers of Endocannabinoid System Activation in Severe Obesity

(2010) Jack C. Sipe et al.   PLoS One

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells

(2009) C. Lipina et al.   DIABETES

Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes

(2009) N. Perwitz et al.   DIABETES OBESITY & METABOLISM

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects

(2009) Vincenzo Di Marzo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Signal transduction of the CB1 cannabinoid receptor

(2009) Gábor Turu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans

(2009) Marica Bordicchia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Anandamide Increases the Differentiation of Rat Adipocytes and Causes PPARγ and CB1 Receptor Upregulation

(2009) Sevasti Karaliota et al.   Obesity

Endocannabinoids selectively enhance sweet taste

(2009) R. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endocannabinoid system as a target for modelling psychosis

(2009) Dagmar Koethe et al.   PSYCHOPHARMACOLOGY

Divergent Effects of Genetic Variation in Endocannabinoid Signaling on Human Threat- and Reward-Related Brain Function

(2008) Ahmad R. Hariri et al.   BIOLOGICAL PSYCHIATRY

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3

(2008) Raphael Rozenfeld et al.   FASEB JOURNAL

Cannabinoids enhance gastric X/A-like cells activity.

(2008) Robert Lukasz Zbucki et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE

Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index

(2008) Tes M Baye et al.   PHARMACOGENOMICS

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One