Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone

Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy

(2017) Timothy A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Inhibition of mTOR Pathway by Rapamycin Decreases P-glycoprotein Expression and Spontaneous Seizures in Pharmacoresistant Epilepsy

(2017) Xiaosa Chi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties

(2017) Shalini Muralikumar et al.   Lipids in Health and Disease

Ketone Bodies as Anti-Seizure Agents

(2017) Timothy A. Simeone et al.   NEUROCHEMICAL RESEARCH

Ketogenic diet treatment increases longevity inKcna1-null mice, a model of sudden unexpected death in epilepsy

(2016) Kristina A. Simeone et al.   EPILEPSIA

Pioglitazone for the treatment of Alzheimer’s disease

(2016) Daniela Galimberti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome

(2016) S. Agrawal et al.   Scientific Reports

Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function

(2016) Silvia S. Antollini et al.   Frontiers in Physiology

Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

(2015) Do Young Kim et al.   ANNALS OF NEUROLOGY

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma

(2015) Sascha Sauer   TRENDS IN PHARMACOLOGICAL SCIENCES

Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease

(2015) Kai Lun Chang et al.   Scientific Reports

Ketones Prevent Oxidative Impairment of Hippocampal Synaptic Integrity through KATP Channels

(2015) Do Young Kim et al.   PLoS One

Ketogenic diets, mitochondria, and neurological diseases

(2014) Lindsey B. Gano et al.   JOURNAL OF LIPID RESEARCH

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

(2014) Cosima Arnold et al.   Pharmacological Reports

The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model

(2013) Christian Grommes et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting PPAR Isoforms Following CNS Injury

(2013) Heather M. Yonutas et al.   CURRENT DRUG TARGETS

Combination treatment of epilepsy with ketogenic diet and concurrent pharmacological inhibition of cytochrome P450 2E1

(2013) Michael Palmer   MEDICAL HYPOTHESES

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice

(2012) Razieh Adabi Mohazab et al.   EPILEPSY RESEARCH

Protective effect of the ketogenic diet in Scn1a mutant mice

(2011) Stacey B. B. Dutton et al.   EPILEPSIA

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

(2011) Sharon S. McDaniel et al.   EPILEPSIA

Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors

(2011) Raghu R. V. Malapaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimal study design for pioglitazone in septic pediatric patients

(2011) Catherine M. T. Sherwin et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Topiramate modulation of β1- and β3-homomeric GABAA receptors

(2011) Timothy A. Simeone et al.   PHARMACOLOGICAL RESEARCH

Anti-apoptotic Actions of PPAR-γ Against Ischemic Stroke

(2010) Wen-Hsuan Fong et al.   MOLECULAR NEUROBIOLOGY

Pparγ2 Is a Key Driver of Longevity in the Mouse

(2009) Carmen Argmann et al.   PLoS Genetics

Ketogenic ratio, calories, and fluids: Do they matter?

(2008) Elaine C. Wirrell   EPILEPSIA

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY