Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I

Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

(2014) Edward O. List et al.   ENDOCRINOLOGY

Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet

(2013) Cheryl A. Conover et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

(2013) A. Lorenzini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity

(2012) Jose Cordoba-Chacon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study

(2012) Christa C van Bunderen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Skeletal Muscle Growth Hormone Receptor Signaling Regulates Basal, but Not Fasting-Induced, Lipid Oxidation

(2012) Archana Vijayakumar et al.   PLoS One

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

(2012) Jeremie Boucher et al.   Nature Communications

Metabolic effects of intra-abdominal fat in GHRKO mice

(2011) Michal M. Masternak et al.   AGING CELL

High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice

(2011) Neha Garg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet-Induced Metabolic Deterioration

(2011) A. Vijayakumar et al.   DIABETES

Separation of the gluconeogenic and mitochondrial functions of PGC-1  through S6 kinase

(2011) Y. Lustig et al.   GENES & DEVELOPMENT

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis

(2010) Y. Wu et al.   CANCER RESEARCH

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism

(2009) Yong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes

(2008) Katie Robertson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype

(2008) Cheryl A Conover et al.   JOURNAL OF ENDOCRINOLOGY