Article
Endocrinology & Metabolism
Marina C. Munoz, Veronica G. Piazza, Valeria Burghi, Jorge F. Giani, Carolina S. Martinez, Nadia S. Cicconi, Nadia Muia, Yimin Fang, Sergio Lavandero, Ana Sotelo, Andrzej Bartke, Patricia A. Pennisi, Fernando P. Dominici, Johanna G. Miquet
Summary: This study investigates the effects of growth hormone (GH) on insulin signaling in the heart and finds that exposure to GH leads to a decreased response to insulin stimulation, which may play a significant role in the development of cardiac pathology.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Basma Radwan, Alvaro Yanez Touzet, Soaad Hammami, Dipesh Chaudhury
Summary: Stress and sleep are tightly regulated through the interaction of homeostatic and circadian processes. Chronic stress can lead to deficient sleep homeostasis, but the understanding of how chronic stress affects sleep regulation and the differences in adaptation to stress on sleep remains limited.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Geronimo Matteo, Myriam P. Hoyeck, Hannah L. Blair, Julia Zebarth, Kayleigh R. C. Rick, Andrew Williams, Remi Gagne, Julie K. Buick, Carole L. Yauk, Jennifer E. Bruin
Summary: Our study found that prolonged low-dose TCDD exposure has minimal effects on glucose homeostasis and islet morphology in chow-fed male and female mice, but promotes maladaptive metabolic responses in HFD-fed females. Females exposed to TCDD showed accelerated onset of HFD-induced hyperglycemia and impaired glucose-induced plasma insulin levels, with changes in islet area and beta cell percentages. TempO-Seq analysis suggested abnormal changes to endocrine and metabolic pathways in female TCDDHFD islets.
Article
Endocrinology & Metabolism
Geronimo Matteo, Myriam P. Hoyeck, Hannah L. Blair, Julia Zebarth, Kayleigh R. C. Rick, Andrew Williams, Remi Gagne, Julie K. Buick, Carole L. Yauk, Jennifer E. Bruin
Summary: The study found that prolonged exposure to low-dose TCDD had minimal effects on glucose homeostasis and islet morphology in chow-fed male and female mice, but promoted maladaptive metabolic responses in HFD-fed females.
Article
Multidisciplinary Sciences
Ivy C. Mason, Daniela Grimaldi, Kathryn J. Reid, Chloe D. Warlick, Roneil G. Malkani, Sabra M. Abbott, Phyllis C. Zee
Summary: This study found that exposure to light during nighttime sleep can negatively affect glucose homeostasis the following morning, potentially through reduced sleep quality, melatonin suppression, or activation of the sympathetic nervous system (SNS) during sleep.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yuan
Summary: The study indicates that BPA exposure has detrimental effects on cognitive function and insulin signaling pathway in male offspring mice, potentially posing a risk for long-term neurodegeneration.
Article
Endocrinology & Metabolism
Marinna C. Okawa, Rebecca M. Tuska, Marissa Lightbourne, Brent S. Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J. Brown
Summary: Insulin receptor signaling plays a role in growth. Patients with hyperinsulinemia and impaired insulin receptor function show impaired growth and lower bone mineral density, while elevated insulin receptor signaling leads to accelerated growth and higher bone mineral density. This suggests that insulin receptor influences growth through direct metabolic effects in bone and indirect effects via the growth hormone-IGF-1 axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Immunology
Hairong Zhao, Jiaming Lu, Furong He, Mei Wang, Yunbo Yan, Binyang Chen, De Xie, Chenxi Xu, Qiang Wang, Weidong Liu, Wei Yu, Yuemei Xi, Linqian Yu, Tetsuya Yamamoto, Hidenori Koyama, Wei Wang, Chenggui Zhang, Jidong Cheng
Summary: This study reveals that hyperuricemia impairs glucose tolerance in hepatic macrophages, leading to insulin resistance and inhibition of IRS2-proteasome degradation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
E. Dale Abel
Summary: Insulin receptors play a critical role in regulating cardiac growth, survival, substrate uptake, and mitochondrial metabolism. Altered insulin signaling in the heart can contribute to ventricular remodeling and heart failure progression. Understanding the role of insulin signaling in cardiac physiology and pathology may have therapeutic implications for conditions like obesity and diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biology
Ze Hong, Saihua Chen, Jing Sun, Dan Cheng, Hanli Guo, Jiahao Mei, Xiang Zhang, Munire Maimaiti, Haiping Hao, Peng Cao, Haiyang Hu, Chen Wang
Summary: STING is mainly expressed and activated in islet macrophages under high-fat diet conditions. Activation of STING leads to islet inflammation and impaired insulin secretion, while inhibiting STING activation can improve these symptoms.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Engineering, Biomedical
Amir Roshanzadeh, Nomin-Erdene Oyunbaatar, Sarina Ehteshamzadeh Ganjbakhsh, Sangwoo Park, Dong-Su Kim, Pooja P. Kanade, Seongsoo Lee, Dong-Weon Lee, Eung-Sam Kim
Summary: The study investigated the detrimental effects of positively surface charged nanoplastics on neonatal rat ventricular myocytes (NRVMs). It found that the reduction of contraction forces in NRVMs was mainly attributed to significant decreases in mitochondrial membrane potentials and cellular metabolism. This multifaceted assessment provides better understanding of the substantial risks of increasing nanoplastic pollution in the hearts of human infants or adults.
Article
Biochemistry & Molecular Biology
Satoshi Matsuzaki, Craig Eyster, Maria F. Newhardt, Jennifer R. Giorgione, Caroline Kinter, Zachary T. Young, Michael Kinter, Kenneth M. Humphries
Summary: The study reveals that insulin can mitigate cardiac oxidative stress in diabetes by regulating endogenous antioxidant activity, with thioredoxin 1 having the ability to directly scavenge superoxide radicals.
Article
Endocrinology & Metabolism
Britta Kunkemoeller, Kuangyang Chen, Sam M. Lockhart, Xuanchun Wang, Christian Rask-Madsen
Summary: Endothelial cell insulin resistance is a major contributor to diabetic complications. The study shows that CITED2 inhibits endothelial insulin signaling through the PI3K/Akt pathway by repressing HIF-dependent IRS-2 expression, and deletion of CITED2 enhances insulin signaling. Therefore, CITED2 is a novel and promising target to improve insulin sensitivity in endothelial cells and prevent vascular complications in diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Environmental Sciences
Xue-Ting Shi, Hua-Long Zhu, Xiao-Feng Xu, Yong-Wei Xiong, Li-Min Dai, Guo-Xiang Zhou, Wei-Bo Liu, Yu-Feng Zhang, De-Xiang Xu, Hua Wang
Summary: This study found that melatonin treatment significantly alleviated environmental cadmium-induced placental angiogenesis disorder and reduction of VEGF-A level. Mechanistically, melatonin reversed the downregulation of VEGF-A protein expression induced by environmental cadmium by inhibiting glucocorticoid receptor (GR) activation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Valeria Burghi, Emiliana B. Echeverria, Maximo H. Sosa, Diego T. Quiroga, Marina C. Munoz, Carlos Davio, Federico Monczor, Natalia C. Fernandez, Fernando P. Dominici
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Cell Biology
Diego T. Quiroga, Johanna G. Miquet, Lorena Gonzalez, Ana Sotelo, Marina C. Munoz, Pedro M. Geraldes, Jorge F. Giani, Dominici Fernando P
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Pharmacology & Pharmacy
Fernando P. Dominici, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, Diego T. Quiroga, Ulrike M. Steckelings, Kenneth E. Bernstein, Jorge F. Giani
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Andrzej Bartke
Summary: Growth hormone plays a crucial role in growth, metabolism, and body composition, with a lack of GH leading to slower growth, delayed maturation, and reduced body size. The mechanistic links between GH and aging involve evolutionarily conserved signaling pathways that balance anabolic/growth processes and longevity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Urology & Nephrology
Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, Giovanna C. Regis, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, David R. Gibb, Fernando P. Dominici, Kenneth E. Bernstein, Jorge F. Giani
Summary: In male db/db mice with type 2 diabetes, salt-sensitive hypertension was observed after exposure to a high-salt diet, while female db/db mice did not develop this condition. The salt-sensitive hypertension in male mice was associated with impaired ENaC downregulation, accompanied by more immune-cell infiltration and higher levels of proinflammatory cytokines. Blocking inflammation prevented the development of salt sensitivity in male db/db mice.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cell Biology
Monica B. Frungieri, Ricardo S. Calandra, Andrzej Bartke, Maria E. Matzkin
Summary: As individuals age, changes in the hypothalamic-pituitary-gonadal axis lead to a decline in gonadal function, impacting fertility and quality of life. This decline exacerbates a mutual crosstalk among oxidative stress, apoptosis, and the inflammatory response in the gonads, adversely affecting fertility. Novel therapeutic interventions using antioxidant, anti-apoptotic, and anti-inflammatory drugs have potential clinical implications on health span and life span.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Endocrinology & Metabolism
Lorena Gonzalez, Maria E. Diaz, Johanna G. Miquet, Ana I. Sotelo, Fernando P. Dominici
Summary: The interaction between EGFR and GH in the liver plays a significant role in the development and progression of liver tumors, with factors such as exposure to supraphysiological GH levels and the pattern of GH administration being important variables to consider.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Yun Zhu, Yimin Fang, David Medina, Andrzej Bartke, Rong Yuan
Summary: Research suggests that early metformin treatment can have effects on development and metabolism in mice, including delayed sexual maturation in females, increased body weight and food consumption, increased tail length and IGF1 levels. Metformin alters insulin and insulin sensitivity in a sex-specific manner in mice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Cell Biology
Maria Eugenia Matzkin, Ricardo Saul Calandra, Soledad Paola Rossi, Andrzej Bartke, Monica Beatriz Frungieri
Summary: The male reproductive system undergoes aging primarily affecting the testes, resulting in decreased sexual hormone levels, altered sperm quality, and reduced fertility. Inflammation, oxidation, and apoptosis are predictors of aging-related diseases, with pro-inflammatory molecules and reactive oxygen species identified as contributing factors for testicular aging. The impact of age-related testicular changes on fertility, reproductive health, and lifespan remains incompletely understood, motivating research into anti-aging interventions and therapies utilizing pharmaceuticals or natural alternatives with anti-inflammatory, antioxidant, and anti-apoptotic properties.
Article
Cell Biology
Veronica G. Piazza, Nadia S. Cicconi, Carolina S. Martinez, Fernando P. Dominici, Johanna G. Miquet, Ana I. Sotelo
Summary: The impact of prolonged GH-treatment on liver was evaluated in non-GH-deficient growing mice. GH administration resulted in increased body weight and organ weight, as well as hepatocellular enlargement and proliferation. Signaling mediators and gene expression associated with GH-induced proliferation were decreased after treatment, indicating sensitization/desensitization cycles. Also, GH treatment showed different effects on males and females, with females exhibiting higher EGFR expression and signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Andrology
Andrzej Bartke, Erin Hascup, Kevin Hascup
Summary: There is growing recognition that sex differences extend beyond reproductive organs and traits related to reproduction, and that sex is a significant biological variable in most characteristics of living organisms. This article focuses on sex differences in responses to anti-aging interventions, which have been shown to vary substantially between females and males. While calorie restriction and certain genetic alterations can extend longevity in both sexes, specific metabolic changes and health benefits differ between women and men. It is clear that understanding the unique mechanisms of aging in females and males is crucial for developing effective and tailored anti-aging interventions.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Cell & Tissue Engineering
Andrzej Bartke
Summary: Research on the biology of aging has shifted focus from studying the effects of aging to searching for mechanisms and interventions that can extend healthspan. The field emphasizes multiple physiological changes, nutrient-dependent signaling pathways, and the impact of age as a risk factor for chronic disease. Major advancements in technology and analysis have provided optimism for the development of safe and widely applicable anti-aging interventions in the near future.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Andrology
Andrzej Bartke, Erin Hascup, Kevin Hascup, Michal M. Masternak
Summary: The complex relationships between growth hormone signaling and mammalian aging are attracting attention, with recent studies showing different impacts of GH on genome maintenance and DNA methylation. GH affects white and brown adipose tissue, influencing lipolysis, fibrosis, and thermogenesis, showing mechanistic links to healthspan and lifespan. Studies on GH deficiency in human subjects and mice provide insights into the mechanisms by which GH influences aging and longevity.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Andrzej Bartke, Savannah Brannan, Erin Hascup, Kevin Hascup, Justin Darcy
Summary: Aging is strongly related to energy metabolism, with evidence showing that restricting energy intake and reducing metabolic rate can slow aging and extend longevity. However, increased energy expenditure has also been associated with improved health and longer life. Recent findings on increasing energy expenditure for thermogenesis have shown potential benefits for preventing obesity, improving metabolic health, and extending lifespan.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Multidisciplinary Sciences
C. S. Martinez, D. E. Igartua, I. Czarnowski, D. A. Feas, S. del V. Alonso, M. J. Prieto