Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression

(2017) Volodymyr Petrenko et al.   GENES & DEVELOPMENT

Principles for circadian orchestration of metabolic pathways

(2017) Kevin Thurley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Time in Metabolic Therapeutics

(2016) Joseph Bass   Cell Metabolism

The Cardiovascular Biology of Glucagon-like Peptide-1

(2016) Daniel J. Drucker   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length

(2016) Ursula Loizides-Mangold et al.   CHRONOBIOLOGY INTERNATIONAL

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells

(2016) C. Saini et al.   DIABETES OBESITY & METABOLISM

α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin

(2016) Rodolphe Dusaulcy et al.   ENDOCRINOLOGY

Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology

(2016) Mark Perelis et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The SCN Clock Governs Circadian Transcription Rhythms in Murine Epididymal White Adipose Tissue

(2016) Isa Kolbe et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Endocrine regulation of circadian physiology

(2016) Anthony H Tsang et al.   JOURNAL OF ENDOCRINOLOGY

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

(2016) Adi Neufeld-Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian time signatures of fitness and disease

(2016) Joseph Bass et al.   SCIENCE

Glucagon-like peptide-1: The missing link in the metabolic clock?

(2016) Patricia L Brubaker et al.   Journal of Diabetes Investigation

The functional significance of the skeletal muscle clock: lessons from Bmal1 knockout models

(2016) Stefano Schiaffino et al.   Skeletal Muscle

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis

(2016) Brianna D. Harfmann et al.   Skeletal Muscle

Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells

(2015) Xiaodong Zhu et al.   DEVELOPMENTAL CELL

The molecular clock as a metabolic rheostat

(2015) M. Perelis et al.   DIABETES OBESITY & METABOLISM

Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames

(2015) Peggy Janich et al.   GENOME RESEARCH

Circadian timing of metabolism in animal models and humans

(2015) C. Dibner et al.   JOURNAL OF INTERNAL MEDICINE

Intrinsic muscle clock is necessary for musculoskeletal health

(2015) Elizabeth A. Schroder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Changes in skeletal muscle fiber types induced by chronic kidney disease

(2015) Stefano Schiaffino et al.   KIDNEY INTERNATIONAL

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

(2015) Florian Atger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

(2015) Laurent Perrin et al.   Molecular Metabolism

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle

(2015) Kenneth A. Dyar et al.   Molecular Metabolism

The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

(2015) Brian A Hodge et al.   Skeletal Muscle

Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation

(2015) Guro F. Giskeødegård et al.   Scientific Reports

The circadian timing system in clinical oncology

(2014) Pasquale F. Innominato et al.   ANNALS OF MEDICINE

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

(2014) Yaarit Adamovich et al.   Cell Metabolism

Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell

(2014) Manuel Gil-Lozano et al.   DIABETES

Circadian disruption in the pathogenesis of metabolic syndrome

(2014) E. Maury et al.   DIABETES & METABOLISM

Liver Clock Protein BMAL1 Promotesde NovoLipogenesis through Insulin-mTORC2-AKT Signaling

(2014) Deqiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Rhythms, the Molecular Clock, and Skeletal Muscle

(2014) Brianna D. Harfmann et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian control of glucose metabolism

(2014) Andries Kalsbeek et al.   Molecular Metabolism

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats

(2013) J. Qian et al.   DIABETES

Circadian Rhythms, Skeletal Muscle Molecular Clocks, and Exercise

(2013) Elizabeth A. Schroder et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Circadian Clock Characteristics Are Altered in Human Thyroid Malignant Nodules

(2013) Tiphaine Mannic et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Involvement of the Clock Gene Rev-erb alpha in the Regulation of Glucagon Secretion in Pancreatic Alpha-Cells

(2013) Elaine Vieira et al.   PLoS One

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

(2013) E. C.-P. Chua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

(2013) Selma Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

The Circadian Clock Gates the Intestinal Stem Cell Regenerative State

(2013) Phillip Karpowicz et al.   Cell Reports

The Circadian Clock Coordinates Ribosome Biogenesis

(2013) Céline Jouffe et al.   PLOS BIOLOGY

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and GL expression

(2013) Fabio Zani et al.   Molecular Metabolism

Circadian regulation of adipose function

(2013) Anton Shostak et al.   Adipocyte

Small molecule modifiers of circadian clocks

(2012) Zheng Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autonomous and self-sustained circadian oscillators displayed in human islet cells

(2012) P. Pulimeno et al.   DIABETOLOGIA

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

The human circadian metabolome

(2012) R. Dallmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers

(2011) Birgitte Andersen et al.   CLINICAL ENDOCRINOLOGY

Circadian rhythms persist without transcription in a eukaryote

(2011) John S. O’Neill et al.   NATURE

Circadian clocks in human red blood cells

(2011) John S. O’Neill et al.   NATURE

Serum factors in older individuals change cellular clock properties

(2011) L. Pagani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Circadian Timing in Cancer Treatments

(2010) Francis Lévi et al.   Annual Review of Pharmacology and Toxicology

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

(2010) L. A. Sadacca et al.   DIABETOLOGIA

CLOCK Regulates Circadian Rhythms of Hepatic Glycogen Synthesis through Transcriptional Activation ofGys2

(2010) Ryosuke Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pax6 Controls the Expression of Critical Genes Involved in Pancreatic α Cell Differentiation and Function

(2010) Yvan Gosmain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extreme makeover of pancreatic α-cells

(2010) Kenneth S. Zaret et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

(2010) J. L. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

(2009) Gwendal Le Martelot et al.   PLOS BIOLOGY

Harmonics of Circadian Gene Transcription in Mammals

(2009) Michael E. Hughes et al.   PLoS Genetics

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Circadian gene expression is resilient to large fluctuations in overall transcription rates

(2008) Charna Dibner et al.   EMBO JOURNAL

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

Molecular insights into human daily behavior

(2008) S. A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Daily Rhythms in Metabolic Liver Enzymes and Plasma Glucose Require a Balance in the Autonomic Output to the Liver

(2007) Cathy Cailotto et al.   ENDOCRINOLOGY