Small molecule modifiers of circadian clocks

Deviation of innate circadian period from 24 h reduces longevity in mice

(2012) Sergiy Libert et al.   AGING CELL

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse

(2012) Rachel Arey et al.   BEHAVIOURAL PHARMACOLOGY

Social Jetlag and Obesity

(2012) Till Roenneberg et al.   CURRENT BIOLOGY

The importance of chronobiology to drug discovery

(2012) Stuart N Farrow et al.   Expert Opinion on Drug Discovery

A role for O-GlcNAcylation in setting circadian clock speed

(2012) E. Y. Kim et al.   GENES & DEVELOPMENT

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity

(2012) Adam C. Silver et al.   IMMUNITY

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

(2012) Darwin Jeyaraj et al.   NATURE

Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork

(2012) Johanna L. Barclay et al.   PLoS One

Coordination of the transcriptome and metabolome by the circadian clock

(2012) K. L. Eckel-Mahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human blood metabolite timetable indicates internal body time

(2012) T. Kasukawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human circadian metabolome

(2012) R. Dallmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

(2012) T. A. Wang et al.   SCIENCE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex

(2012) K. Padmanabhan et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

Speed control: cogs and gears that drive the circadian clock

(2012) Xiangzhong Zheng et al.   TRENDS IN NEUROSCIENCES

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

(2011) Jae Wook Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cyanobacterial Circadian System: From Biophysics to Bioevolution

(2011) Carl Hirschie Johnson et al.   Annual Review of Biophysics

NEMO/NLK Phosphorylates PERIOD to Initiate a Time-Delay Phosphorylation Circuit that Sets Circadian Clock Speed

(2011) Joanna C. Chiu et al.   CELL

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

NEMO Kinase Contributes to Core Period Determination by Slowing the Pace of the Drosophila Circadian Oscillator

(2011) Wangjie Yu et al.   CURRENT BIOLOGY

The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis

(2011) Laura A Solt et al.   Future Medicinal Chemistry

Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms

(2011) Yongjin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-transcriptional control of circadian rhythms

(2011) S. Kojima et al.   JOURNAL OF CELL SCIENCE

Circadian rhythms persist without transcription in a eukaryote

(2011) John S. O’Neill et al.   NATURE

Structure of full-length Drosophila cryptochrome

(2011) Brian D. Zoltowski et al.   NATURE

Timing of plant immune responses by a central circadian regulator

(2011) Wei Wang et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα

(2010) Daniel Grant et al.   ACS Chemical Biology

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

Ligand-Binding PAS Domains in a Genomic, Cellular, and Structural Context

(2010) Jonathan T. Henry et al.   Annual Review of Microbiology

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

(2010) L. A. Sadacca et al.   DIABETOLOGIA

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Clocks not winding down: unravelling circadian networks

(2010) Eric E. Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shift work: coping with the biological clock

(2010) J. Arendt   OCCUPATIONAL MEDICINE-OXFORD

The Physiological Period Length of the Human Circadian Clock In Vivo Is Directly Proportional to Period in Human Fibroblasts

(2010) Lucia Pagani et al.   PLoS One

A circadian clock in Saccharomyces cerevisiae

(2010) Z. Eelderink-Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of the human circadian system, exercise, and their interaction on cardiovascular function

(2010) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

(2010) T.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

(2009) Eric E. Zhang et al.   CELL

High-Throughput Screening and Chemical Biology: New Approaches for Understanding Circadian Clock Mechanisms

(2009) Tsuyoshi Hirota et al.   CHEMISTRY & BIOLOGY

Vascular Disease in Mice With a Dysfunctional Circadian Clock

(2009) Ciprian B. Anea et al.   CIRCULATION

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock

(2009) B. Maier et al.   GENES & DEVELOPMENT

Clock is important for food and circadian regulation of macronutrient absorption in mice

(2009) Xiaoyue Pan et al.   JOURNAL OF LIPID RESEARCH

Selective Inhibition of Casein Kinase 1  Minimally Alters Circadian Clock Period

(2009) K. M. Walton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B

(2009) Jason Key et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor- /  Inverse Agonist

(2009) N. Kumar et al.   MOLECULAR PHARMACOLOGY

Measurement of internal body time by blood metabolomics

(2009) Y. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial ligand binding within the HIF2  PAS-B domain of the HIF2 transcription factor

(2009) T. H. Scheuermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CKI / -dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

(2009) Y. Isojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

(2009) Y. He et al.   SCIENCE

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

(2009) Y. Tsuchiya et al.   Science Signaling

Structure and Signaling Mechanism of Per-ARNT-Sim Domains

(2009) Andreas Möglich et al.   STRUCTURE

The Implications of Multiple Circadian Clock Origins

(2009) Michael Rosbash   PLOS BIOLOGY

The In(put)s and Out(put)s of the Drosophila Circadian Clock

(2008) Catharine E. Boothroyd et al.   Annals of the New York Academy of Sciences

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

(2008) Elizabeth J. Westgate et al.   CIRCULATION

Phase Resetting of the Mammalian Circadian Clock by DNA Damage

(2008) Małgorzata Oklejewicz et al.   CURRENT BIOLOGY

How a cyanobacterium tells time

(2008) Guogang Dong et al.   CURRENT OPINION IN MICROBIOLOGY

Ligand modulation of REV-ERB  function resets the peripheral circadian clock in a phasic manner

(2008) Q. J. Meng et al.   JOURNAL OF CELL SCIENCE

Soluble 3′,6-Substituted Indirubins with Enhanced Selectivity toward Glycogen Synthase Kinase -3 Alter Circadian Period

(2008) Konstantina Vougogiannopoulou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of TGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts

(2008) Naohiro Kon et al.   NATURE CELL BIOLOGY

Combination chemical genetics

(2008) Joseph Lehár et al.   Nature Chemical Biology

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

Disturbed Clockwork Resetting in Sharp-1 and Sharp-2 Single and Double Mutant Mice

(2008) Moritz J. Rossner et al.   PLoS One

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 

(2008) T. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

(2008) J. S. O'Neill et al.   SCIENCE

Circadian Transcription Contributes to Core Period Determination in Drosophila

(2008) Sebastian Kadener et al.   PLOS BIOLOGY

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

(2007) Molly S. Bray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY