Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells

(2016) C. Saini et al.   DIABETES OBESITY & METABOLISM

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Glucagon is the key factor in the development of diabetes

(2016) Young H. Lee et al.   DIABETOLOGIA

α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin

(2016) Rodolphe Dusaulcy et al.   ENDOCRINOLOGY

Trends in diabetes: sounding the alarm

(2016) Etienne G Krug   LANCET

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

(2016) Adi Neufeld-Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

(2015) Gad Asher et al.   CELL

Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells

(2015) Xiaodong Zhu et al.   DEVELOPMENTAL CELL

The molecular clock as a metabolic rheostat

(2015) M. Perelis et al.   DIABETES OBESITY & METABOLISM

Circadian timing of metabolism in animal models and humans

(2015) C. Dibner et al.   JOURNAL OF INTERNAL MEDICINE

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

(2015) Florian Atger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pancreatic clock times insulin release

(2015) C. Dibner et al.   SCIENCE

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

(2015) Laurent Perrin et al.   Molecular Metabolism

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Circadian disruption in the pathogenesis of metabolic syndrome

(2014) E. Maury et al.   DIABETES & METABOLISM

Neural regulation of pancreatic islet cell mass and function

(2014) B. Thorens   DIABETES OBESITY & METABOLISM

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats

(2013) J. Qian et al.   DIABETES

Circadian Clock Characteristics Are Altered in Human Thyroid Malignant Nodules

(2013) Tiphaine Mannic et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Involvement of the Clock Gene Rev-erb alpha in the Regulation of Glucagon Secretion in Pancreatic Alpha-Cells

(2013) Elaine Vieira et al.   PLoS One

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

The Circadian Clock Coordinates Ribosome Biogenesis

(2013) Céline Jouffe et al.   PLOS BIOLOGY

Autonomous and self-sustained circadian oscillators displayed in human islet cells

(2012) P. Pulimeno et al.   DIABETOLOGIA

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

The role of dysregulated glucagon secretion in type 2 diabetes

(2011) D. D'Alessio   DIABETES OBESITY & METABOLISM

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

(2010) L. A. Sadacca et al.   DIABETOLOGIA

Extreme makeover of pancreatic α-cells

(2010) Kenneth S. Zaret et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

A software solution for recording circadian oscillator features in time-lapse live cell microscopy

(2010) Daniel Sage et al.   Cell Division

Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas

(2009) Natalia Gustavsson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation

(2009) Anne Wojtusciszyn et al.   TRANSPLANT INTERNATIONAL

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism