Genetic and epigenetic drivers of neuroendocrine tumours (NET)

Hypo-methylation mediates chromosomal instability in pancreatic NET

(2017) I Marinoni et al.   ENDOCRINE-RELATED CANCER

A MUTYH germline mutation is associated with small intestinal neuroendocrine tumors

(2017) Jan P Dumanski et al.   ENDOCRINE-RELATED CANCER

Progressive epigenetic dysregulation in neuroendocrine tumour liver metastases

(2017) Anna Karpathakis et al.   ENDOCRINE-RELATED CANCER

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States

(2017) Arvind Dasari et al.   JAMA Oncology

Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase

(2016) Zijie Feng et al.   CANCER RESEARCH

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors

(2016) Aatur D. Singhi et al.   CLINICAL CANCER RESEARCH

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis

(2016) Wenzel M. Hackeng et al.   HUMAN PATHOLOGY

Upregulation of Key Molecules for Targeted Imaging and Therapy

(2016) V. F. Taelman et al.   JOURNAL OF NUCLEAR MEDICINE

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes

(2016) João Vinagre et al.   Scientific Reports

High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer

(2016) Cailu Song et al.   Scientific Reports

Somatic Mutations and Genetic Heterogeneity at the CDKN1B Locus in Small Intestinal Neuroendocrine Tumors

(2015) Joakim Crona et al.   ANNALS OF SURGICAL ONCOLOGY

O6-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents

(2015) T Walter et al.   BRITISH JOURNAL OF CANCER

RETRACTED ARTICLE: Down-regulation of miR-133a and miR-539 are associated with unfavorable prognosis in patients suffering from osteosarcoma

(2015) Alireza Mirghasemi et al.   Cancer Cell International

Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor

(2015) A. Karpathakis et al.   CLINICAL CANCER RESEARCH

Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours

(2015) C. P. Pipinikas et al.   ENDOCRINE-RELATED CANCER

A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase

(2015) Yoshitatsu Sei et al.   GASTROENTEROLOGY

Frequency and Clinical Correlates of Somatic Ying Yang 1 Mutations in Sporadic Insulinomas

(2015) Urs D. Lichtenauer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells

(2015) Yvonne Arvidsson et al.   NEUROENDOCRINOLOGY

Identification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression

(2015) Ida Rapa et al.   NEUROENDOCRINOLOGY

Pathology, genetics and precursors of human and experimental pancreatic neoplasms: An update

(2015) Irene Esposito et al.   PANCREATOLOGY

Neomorphic effects of recurrent somatic mutations inYin Yang 1in insulin-producing adenomas

(2015) M. Kyle Cromer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

(2015) A. Sadanandam et al.   Cancer Discovery

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hyperplasia to Neoplasia Sequence of Duodenal and Pancreatic Neuroendocrine Diseases and Pseudohyperplasia of the PP-cells in the Pancreas

(2014) Günter Klöppel et al.   ENDOCRINE PATHOLOGY

Global hypomethylation and promoter methylation in small intestinal neuroendocrine tumors

(2014) Omid Fotouhi et al.   Epigenetics

Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors

(2014) Hyoun Wook Lee et al.   Korean Journal of Pathology

Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study

(2014) Fabian Dominik Mairinger et al.   MODERN PATHOLOGY

Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation

(2014) Wenchu Lin et al.   MOLECULAR CANCER RESEARCH

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Prognostic Relevance of Aberrant DNA Methylation in G1 and G2 Pancreatic Neuroendocrine Tumors

(2014) Michele Stefanoli et al.   NEUROENDOCRINOLOGY

Prognostic and Predictive Roles of MGMT Protein Expression and Promoter Methylation in Sporadic Pancreatic Neuroendocrine Neoplasms

(2014) Anja Maria Schmitt et al.   NEUROENDOCRINOLOGY

MicroRNA-133a Suppresses Multiple Oncogenic Membrane Receptors and Cell Invasion in Non-Small Cell Lung Carcinoma

(2014) Lu-Kai Wang et al.   PLoS One

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

(2014) R. Ohki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients

(2014) Li-Li Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

(2014) Lynnette Fernandez-Cuesta et al.   Nature Communications

Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

(2014) Bo Deng et al.   Cell and Bioscience

Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization

(2013) Jamileh Hashemi et al.   BMC CANCER

microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer

(2013) K Ueno et al.   BRITISH JOURNAL OF CANCER

The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas

(2013) Hailin Tang et al.   CURRENT CANCER DRUG TARGETS

Global DNA methylation patterns through an array-based approach in small intestinal neuroendocrine tumors

(2013) Alberto Delgado Verdugo et al.   ENDOCRINE-RELATED CANCER

TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors

(2013) Katarina Edfeldt et al.   ENDOCRINE-RELATED CANCER

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

The genomic landscape of small intestine neuroendocrine tumors

(2013) Michaela S. Banck et al.   JOURNAL OF CLINICAL INVESTIGATION

Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors

(2013) Su-Chen Li et al.   MODERN PATHOLOGY

MicroRNA-409-3p inhibits migration and invasion of bladder cancer cells via targeting c-Met

(2013) Xin Xu et al.   MOLECULES AND CELLS

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

(2013) Joshua M Francis et al.   NATURE GENETICS

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Menin mediates epigenetic regulation via histone H3 lysine 9 methylation

(2013) Y-J Yang et al.   Cell Death & Disease

Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1

(2013) Yanan Cao et al.   Nature Communications

Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin

(2012) Junfeng Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion

(2012) Zheng-sheng Wu et al.   BMC CANCER

miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin

(2012) Chunhua Weng et al.   CANCER LETTERS

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

(2012) Sharon M. Blättler et al.   Cell Metabolism

Accelerated Proliferation and Differential Global Gene Expression in Pancreatic Islets of Five-Week-Old HeterozygousMen1Mice:Men1Is a Haploinsufficient Suppressor

(2012) Margareta H. Lejonklou et al.   ENDOCRINOLOGY

Methylation of RASSF1A gene promoter is regulated by p53 and DAXX

(2012) Hailong Zhang et al.   FASEB JOURNAL

Neurofibromatosis type 1: from genotype to phenotype

(2012) Eric Pasmant et al.   JOURNAL OF MEDICAL GENETICS

Molecular pathology and genetics of pancreatic endocrine tumours

(2012) Gabriele Capurso et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

(2012) Roeland F de Wilde et al.   MODERN PATHOLOGY

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Altered expression of microRNA miR-21, miR-155, and let-7a and their roles in pulmonary neuroendocrine tumors

(2012) Hyoun Wook Lee et al.   PATHOLOGY INTERNATIONAL

Genome-Wide Characterization of Menin-Dependent H3K4me3 Reveals a Specific Role for Menin in the Regulation of Genes Implicated in MEN1-Like Tumors

(2012) Sunita K. Agarwal et al.   PLoS One

Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries

(2011) V. Corbo et al.   ANNALS OF ONCOLOGY

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

(2011) Giorgio Malpeli et al.   BMC CANCER

The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors

(2011) Ben Lawrence et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

The functional significance of miR-1 and miR-133a in renal cell carcinoma

(2011) Kazumori Kawakami et al.   EUROPEAN JOURNAL OF CANCER

High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not

(2011) Jennifer J. Findeis-Hosey et al.   HUMAN PATHOLOGY

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

(2011) Shigeki Iwase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4

(2011) K Schramedei et al.   ONCOGENE

MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers

(2011) B Zheng et al.   ONCOGENE

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications

(2011) Nakarin Kitkumthorn et al.   Clinical Epigenetics

Multiple roles of ATM in monitoring and maintaining DNA integrity

(2010) Frederick A. Derheimer et al.   FEBS LETTERS

Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

(2010) Janet L. Cunningham et al.   GENES CHROMOSOMES & CANCER

Genetic analysis of von Hippel-Lindau disease

(2010) Morgan Nordstrom-O'Brien et al.   HUMAN MUTATION

Periampullary and Duodenal Neoplasms in Neurofibromatosis Type 1: Two Cases and an Updated 20-Year Review of the Literature Yielding 76 Cases

(2010) Daniel Relles et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KIT is an Independent Prognostic Marker for Pancreatic Endocrine Tumors

(2009) Lizhi Zhang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoids

(2009) Ellinor Andersson et al.   ENDOCRINE-RELATED CANCER

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression

(2009) Emelyne Dejeux et al.   ENDOCRINE-RELATED CANCER

VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors

(2009) A M Schmitt et al.   ENDOCRINE-RELATED CANCER

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

(2009) P. Olson et al.   GENES & DEVELOPMENT

H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1

(2009) Christian Magerl et al.   HUMAN PATHOLOGY

Gastrointestinal and Retroperitoneal Manifestations of Type 1 Neurofibromatosis

(2009) Ursula Basile et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1

(2009) Hilde Brems et al.   LANCET ONCOLOGY

MicroRNA expression in ileal carcinoid tumors: downregulation of microRNA-133a with tumor progression

(2009) Katharina Ruebel et al.   MODERN PATHOLOGY

DEVELOPMENTAL BIOLOGY: Pluripotent Chromatin State

(2009) A. S. Chi et al.   SCIENCE

Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors

(2008) A. Couvelard et al.   CLINICAL CANCER RESEARCH

Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation

(2008) L. A. Puto et al.   GENES & DEVELOPMENT

High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss

(2008) Matthew H. Kulke et al.   GENES CHROMOSOMES & CANCER

One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States

(2008) James C. Yao et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

(2007) Manuel C. Lemos et al.   HUMAN MUTATION