FGF21 Requires βklotho to Act In Vivo

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

(2012) Timo D. Müller et al.   JOURNAL OF PEPTIDE SCIENCE

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo

(2012) Andrew C. Adams et al.   PLoS One

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

(2012) Murielle M. Véniant et al.   PLoS One

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

(2011) Clarence Hale et al.   ENDOCRINOLOGY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unknown

(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

(2010) Nobuyuki Itoh   CELL AND TISSUE RESEARCH

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 reloaded: challenges of a rapidly growing field

(2010) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fibroblast growth factor 21: from pharmacology to physiology

(2009) Steven A Kliewer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

FGFs and metabolism

(2009) Alexei Kharitonenkov   CURRENT OPINION IN PHARMACOLOGY

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Different roles of N- and C- termini in the functional activity of FGF21

(2009) Radmila Micanovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Circadian expression ofFGF21is induced by PPARα activation in the mouse liver

(2008) Katsutaka Oishi et al.   FEBS LETTERS

FGF21 N- and C-termini play different roles in receptor interaction and activation

(2008) Junming Yie et al.   FEBS LETTERS

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY