Current Trends in Multidrug Optimization: An Alley of Future Successful Treatment of Complex Disorders

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

(2016) Aleidy Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform

(2016) Ali Zarrinpar et al.   Science Translational Medicine

Mechanism-Independent Optimization of Combinatorial Nanodiamond and Unmodified Drug Delivery Using a Phenotypically Driven Platform Technology

(2015) Hann Wang et al.   ACS Nano

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

(2015) Andrea Weiss et al.   ANGIOGENESIS

Systematic synergy modeling: understanding drug synergy from a systems biology perspective

(2015) Di Chen et al.   BMC Systems Biology

BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma—A Trial of the ECOG–ACRIN Cancer Research Group (E2804)

(2015) Keith T. Flaherty et al.   JOURNAL OF CLINICAL ONCOLOGY

The influence of subclonal resistance mutations on targeted cancer therapy

(2015) Michael W. Schmitt et al.   Nature Reviews Clinical Oncology

Precision medicine: Beyond the inflection point

(2015) Sam Hawgood et al.   Science Translational Medicine

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

(2015) Sandra Misale et al.   Nature Communications

Systems biology approaches for advancing the discovery of effective drug combinations

(2015) Karen A Ryall et al.   Journal of Cheminformatics

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

(2015) Andrea Weiss et al.   Scientific Reports

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

(2015) Federica Lombardi et al.   PLoS Computational Biology

Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

(2015) Anil Korkut et al.   eLife

A streamlined search technology for identification of synergistic drug combinations

(2015) Andrea Weiss et al.   Scientific Reports

The emerging quest for the optimal angiostatic combination therapy: Figure 1

(2014) Arjan W. Griffioen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation

(2014) Karen A. Ryall et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Machine learning-based prediction of drug–drug interactions by integrating drug phenotypic, therapeutic, chemical, and genomic properties

(2014) Feixiong Cheng et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics

(2014) A. A. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting polypharmacology for drug target deconvolution

(2014) Taranjit Singh Gujral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An application of a Hill-based response surface model for a drug combination experiment on lung cancer

(2014) Shaoyang Ning et al.   STATISTICS IN MEDICINE

Uncovering Scaling Laws to Infer Multidrug Response of Resistant Microbes and Cancer Cells

(2014) Kevin B. Wood et al.   Cell Reports

Computational Analyses of Synergism in Small Molecular Network Motifs

(2014) Yili Zhang et al.   PLoS Computational Biology

In vitro clinical trials: the future of cell-based profiling

(2014) Nathan T. Ross et al.   Frontiers in Pharmacology

Bayesian Active Learning for Drug Combinations

(2013) Mijung Park et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

(2013) Michael P. Menden et al.   PLoS One

Development and validation of a general approach to predict and quantify the synergism of anti-cancer drugs using experimental design and artificial neural networks

(2013) Tiziana Pivetta et al.   TALANTA

Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways

(2013) Jing Tang et al.   PLoS Computational Biology

Perturbation Biology: Inferring Signaling Networks in Cellular Systems

(2013) Evan J. Molinelli et al.   PLoS Computational Biology

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

The drug cocktail network

(2012) Ke-Jia Xu et al.   BMC Systems Biology

Predicting and characterizing selective multiple drug treatments for metabolic diseases and cancer

(2012) Giuseppe Facchetti et al.   BMC Systems Biology

Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli

(2012) Kevin B Wood et al.   BMC Systems Biology

Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

(2012) J. W. Tyner et al.   CANCER RESEARCH

Predicting Response to Antiretroviral Treatment by Machine Learning: The EuResist Project

(2012) Maurizio Zazzi et al.   INTERVIROLOGY

Drug—drug interaction through molecular structure similarity analysis

(2012) Santiago Vilar et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Defining principles of combination drug mechanisms of action

(2012) J. R. Pritchard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer

(2012) R. A. Beckman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of fractional factorial designs to study drug combinations

(2012) Jessica Jaynes et al.   STATISTICS IN MEDICINE

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

Rapidly optimizing an aptamer based BoNT sensor by feedback system control (FSC) scheme

(2011) Fang Wei et al.   BIOSENSORS & BIOELECTRONICS

Enhanced stochastic optimization algorithm for finding effective multi-target therapeutics

(2011) Byung-Jun Yoon   BMC BIOINFORMATICS

Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations

(2011) Koen Van der Borght et al.   BMC BIOINFORMATICS

Systematic quantitative characterization of cellular responses induced by multiple signals

(2011) Ibrahim Al-Shyoukh et al.   BMC Systems Biology

Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial

(2011) Sylvie Négrier et al.   LANCET ONCOLOGY

Control of Kaposi's Sarcoma-Associated Herpesvirus Reactivation Induced by Multiple Signals

(2011) Fuqu Yu et al.   PLoS One

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

(2011) Hideaki Tsutsui et al.   Nature Communications

Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data

(2011) Xing-Ming Zhao et al.   PLoS Computational Biology

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

(2010) Matthew J Kraeutler et al.   BMC Systems Biology

Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

(2010) S. Iadevaia et al.   CANCER RESEARCH

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

(2010) Naama Geva-Zatorsky et al.   CELL

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Statistical Metamodeling for Revealing Synergistic Antimicrobial Interactions

(2010) Chia Hsiang Chen et al.   PLoS One

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

(2009) Kristy J. Gotink et al.   ANGIOGENESIS

Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

(2009) Dominik M Wittmann et al.   BMC Systems Biology

Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells

(2009) R. G. Zinner et al.   MOLECULAR CANCER THERAPEUTICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer

(2009) Jolien Tol et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems approaches and algorithms for discovery of combinatorial therapies

(2009) Jacob D. Feala et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

(2009) Bree B. Aldridge et al.   PLoS Computational Biology

Selecting anti-HIV therapies based on a variety of genomic and clinical factors

(2008) M. Rosen-Zvi et al.   BIOINFORMATICS

Combination Targeted Therapy With Sorafenib and Bevacizumab Results in Enhanced Toxicity and Antitumor Activity

(2008) Nilofer S. Azad et al.   JOURNAL OF CLINICAL ONCOLOGY

Models from experiments: combinatorial drug perturbations of cancer cells

(2008) Sven Nelander et al.   Molecular Systems Biology

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

(2008) Pak Kin Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Search Algorithms as a Framework for the Optimization of Drug Combinations

(2008) Diego Calzolari et al.   PLoS Computational Biology