Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
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Title
Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
Authors
Keywords
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Journal
eLife
Volume 4, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2015-08-18
DOI
10.7554/elife.04640
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Note: Only part of the references are listed.- Causal network inference using biochemical kinetics
- (2014) Chris J. Oates et al. BIOINFORMATICS
- WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
- (2014) Jamie N. Anastas et al. JOURNAL OF CLINICAL INVESTIGATION
- BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD
- (2014) W. Fiskus et al. MOLECULAR CANCER THERAPEUTICS
- Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma
- (2014) Chong Sun et al. NATURE
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma
- (2014) Georgina V. Long et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intratumor heterogeneity alters most effective drugs in designed combinations
- (2014) B. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
- (2013) M. F. Segura et al. CANCER RESEARCH
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Network quantification of EGFR signaling unveils potential for targeted combination therapy
- (2013) B. Klinger et al. Molecular Systems Biology
- Emerging landscape of oncogenic signatures across human cancers
- (2013) Giovanni Ciriello et al. NATURE GENETICS
- Drug Synergy Screen and Network Modeling in Dedifferentiated Liposarcoma Identifies CDK4 and IGF1R as Synergistic Drug Targets
- (2013) M. L. Miller et al. Science Signaling
- Evaluating cell lines as tumour models by comparison of genomic profiles
- (2013) Silvia Domcke et al. Nature Communications
- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
- (2013) Alexandre Puissant et al. Cancer Discovery
- MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
- (2013) N. Wagle et al. Cancer Discovery
- The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
- (2013) E. M. Van Allen et al. Cancer Discovery
- Perturbation Biology: Inferring Signaling Networks in Cellular Systems
- (2013) Evan J. Molinelli et al. PLoS Computational Biology
- Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
- (2012) Piro Lito et al. CANCER CELL
- ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
- (2012) N. J. Clegg et al. CANCER RESEARCH
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
- (2012) Anirudh Prahallad et al. NATURE
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
- (2012) W. W. Lockwood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
- (2012) Levi A. Garraway et al. Cancer Discovery
- Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'
- (2011) Christian Bender et al. BMC BIOINFORMATICS
- Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models
- (2011) J. Saez-Rodriguez et al. CANCER RESEARCH
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF
- (2011) F Xing et al. ONCOGENE
- Targeting MYC dependence in cancer by inhibiting BET bromodomains
- (2011) J. A. Mertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
- (2010) Cory M. Johannessen et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- The BioPAX community standard for pathway data sharing
- (2010) Emek Demir et al. NATURE BIOTECHNOLOGY
- Pathway Commons, a web resource for biological pathway data
- (2010) E. G. Cerami et al. NUCLEIC ACIDS RESEARCH
- A Global Protein Kinase and Phosphatase Interaction Network in Yeast
- (2010) A. Breitkreutz et al. SCIENCE
- Variable slope normalization of reverse phase protein arrays
- (2009) E. Shannon Neeley et al. BIOINFORMATICS
- Algorithms for effective querying of compound graph-based pathway databases
- (2009) Ugur Dogrusoz et al. BMC BIOINFORMATICS
- Molecular Markers of Tumor Progression in Melanoma
- (2009) Joshua Rother et al. CURRENT GENOMICS
- Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data
- (2009) William W Chen et al. Molecular Systems Biology
- Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
- (2009) Julio Saez-Rodriguez et al. Molecular Systems Biology
- The Systems Biology Graphical Notation
- (2009) Nicolas Le Novère et al. NATURE BIOTECHNOLOGY
- V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
- (2009) C. A. Pratilas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Models from experiments: combinatorial drug perturbations of cancer cells
- (2008) Sven Nelander et al. Molecular Systems Biology
- Modelling Myc inhibition as a cancer therapy
- (2008) Laura Soucek et al. NATURE
- PID: the Pathway Interaction Database
- (2008) Carl F. Schaefer et al. NUCLEIC ACIDS RESEARCH
- Reactome knowledgebase of human biological pathways and processes
- (2008) L. Matthews et al. NUCLEIC ACIDS RESEARCH
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