Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy
Published 2016 View Full Article
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Title
Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2016-02-03
DOI
10.3389/fonc.2016.00021
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- APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
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- Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
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